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protoporphyrin ix and Prostatic Neoplasms

protoporphyrin ix has been researched along with Prostatic Neoplasms in 27 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Prostatic Neoplasms: Tumors or cancer of the PROSTATE.

Research Excerpts

ExcerptRelevanceReference
"Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light."1.48Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy. ( Arellano, DL; Chauhan, K; Fournier, PGJ; Hirata, GA; Jain, A; Juárez, P; Sengar, P; Verdugo-Meza, A, 2018)
"Here we created uniformly sized PC-3 prostate cancer spheroids using a 3D culture plate (EZSPHERE)."1.43Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. ( Hagiya, Y; Inoue, K; Kobayashi, T; Matsumoto, K; Nakajima, M; Nakayama, T; Ogura, SI; Okajima, H; Otsuka, S; Shuin, T; Tanaka, T, 2016)
"Past attempts at detecting prostate cancer (PCa) cells in voided urine by traditional cytology have been impeded by undesirably low sensitivities but high specificities."1.40Photodynamic diagnosis of shed prostate cancer cells in voided urine treated with 5-aminolevulinic acid. ( Anai, S; Chihara, Y; Fujimoto, K; Hirao, Y; Hirayama, A; Kuwada, M; Miyake, M; Nakai, Y; Tanaka, N; Yoshida, K, 2014)
" Lastly, cell uptake study and PET image-based pharmacokinetic analyses of the PPIX-PEG6-BBN analog were carried out in a human prostate cancer cell line, PC-3, which highly expresses the GRP receptor, and PC-3 tumor-bearing mice."1.39The synthesis of 64Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents. ( Mukai, H; Wada, Y; Watanabe, Y, 2013)
"The prostate and breast cancer cell lines were investigated: MCF-7, a human breast cancer responsive to androgen therapy; MDA-MB231, a more aggressive human breast cancer non-responsive to androgen therapy; LNCaP, a lymphonodal metastasis of prostate carcinoma responsive to androgen therapy; DU-145, a human prostate cancer non-responsive to androgen therapy."1.37Inhibition of cell growth induced by photosensitizer PP(Arg)2-mediated photodynamic therapy in human breast and prostate cell lines. Part I. ( Małecki, M; Nowak-Stępniowska, A; Padzik-Graczyk, A; Romiszewska, A; Wiktorska, K, 2011)
"Prostate cancer is one of the most common types of cancer in men, and unfortunately many prostate tumours remain asymptomatic until they reach advanced stages."1.36Intrinsic fluorescence of protoporphyrin IX from blood samples can yield information on the growth of prostate tumours. ( Bellini, MH; Courrol, LC; de Oliveira Silva, FR; Schor, N; Tristão, VR; Vieira, ND, 2010)
"Human prostate cancer (DU-145) and squamous carcinoma (A431) cells were used as experimental model."1.35Diamino acid derivatives of PpIX as potential photosensitizers for photodynamic therapy of squamous cell carcinoma and prostate cancer: in vitro studies. ( Glosnicka, R; Graczyk, A; Juzeniene, A; Kwitniewski, M; Ma, LW; Moan, J, 2009)
" Searching for new approaches, we tested a known inducer of cellular differentiation, methotrexate (MTX), in combination with ALA-PDT in LNCaP cells."1.33Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells. ( Anand, S; Chang, Y; Hasan, T; Mai, Z; Maytin, EV; Ortel, BJ; Sinha, AK, 2006)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (11.11)18.2507
2000's5 (18.52)29.6817
2010's19 (70.37)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sengar, P1
Juárez, P1
Verdugo-Meza, A1
Arellano, DL1
Jain, A1
Chauhan, K1
Hirata, GA1
Fournier, PGJ1
Nakai, Y2
Miyake, M2
Anai, S2
Hori, S1
Tatsumi, Y1
Morizawa, Y1
Onisi, S1
Tanaka, N2
Fujimoto, K2
Mukai, H1
Wada, Y1
Watanabe, Y1
Bozzini, G1
Colin, P1
Betrouni, N1
Maurage, CA1
Leroy, X1
Simonin, S1
Martin-Schmitt, C1
Villers, A1
Mordon, S1
Fukuhara, H1
Inoue, K2
Kurabayashi, A1
Furihata, M1
Fujita, H1
Utsumi, K1
Sasaki, J1
Shuin, T2
Yamauchi, M1
Honda, N1
Hazama, H1
Tachikawa, S1
Nakamura, H1
Kaneda, Y1
Awazu, K1
Kuwada, M1
Chihara, Y1
Hirayama, A1
Yoshida, K1
Hirao, Y1
Fahey, JM2
Girotti, AW2
Bui, B2
Liu, L1
Chen, W2
Homayoni, H1
Ma, L1
Zhang, J1
Sahi, SK1
Rashidi, LH1
Nakayama, T1
Otsuka, S1
Kobayashi, T1
Okajima, H1
Matsumoto, K1
Hagiya, Y1
Nakajima, M1
Tanaka, T1
Ogura, SI1
Bazak, J1
Wawak, K1
Korytowski, W1
Fidanzi-Dugas, C1
Liagre, B1
Chemin, G1
Perraud, A1
Carrion, C1
Couquet, CY1
Granet, R1
Sol, V1
Léger, DY1
Kwitniewski, M1
Juzeniene, A1
Ma, LW1
Glosnicka, R1
Graczyk, A1
Moan, J1
de Oliveira Silva, FR1
Bellini, MH3
Tristão, VR1
Schor, N3
Vieira, ND3
Courrol, LC3
Silva, FR2
Nabeshima, CT2
Nowak-Stępniowska, A2
Małecki, M2
Wiktorska, K2
Romiszewska, A2
Padzik-Graczyk, A2
Teper, E1
Makhov, P1
Golovine, K1
Canter, DJ1
Myers, CB1
Kutikov, A1
Sterious, SN1
Uzzo, RG1
Kolenko, VM1
Ortel, B1
Sharlin, D1
O'Donnell, D1
Sinha, AK2
Maytin, EV2
Hasan, T3
Zaak, D1
Sroka, R1
Stocker, S1
Bise, K1
Lein, M1
Höppner, M1
Frimberger, D1
Schneede, P1
Reich, O1
Kriegmair, M1
Knüchel, R1
Baumgartner, R1
Hofstetter, A1
Anand, S1
Ortel, BJ1
Chang, Y1
Mai, Z1
Bogaards, A1
Sterenborg, HJ1
Trachtenberg, J1
Wilson, BC1
Lilge, L1
Chang, SC1
Buonaccorsi, GA1
MacRobert, AJ1
Bown, SG1
Momma, T1
Hamblin, MR1
Chakrabarti, P1
Orihuela, E1
Egger, N1
Neal, DE1
Gangula, R1
Adesokun, A1
Motamedi, M1

Other Studies

27 other studies available for protoporphyrin ix and Prostatic Neoplasms

ArticleYear
Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy.
    Journal of nanobiotechnology, 2018, Feb-27, Volume: 16, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Folic Acid; Luminescent Agents; Male; Mice; Nan

2018
Spectrophotometric photodynamic diagnosis of prostate cancer cells excreted in voided urine using 5-aminolevulinic acid.
    Lasers in medical science, 2018, Volume: 33, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Area Under Curve; Biomarkers, Tumor; Biopsy; Ce

2018
The synthesis of 64Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents.
    Annals of nuclear medicine, 2013, Volume: 27, Issue:7

    Topics: Amino Acid Sequence; Animals; Biological Transport; Bombesin; Cell Line, Tumor; Chelating Agents; Co

2013
Efficiency of 5-ALA mediated photodynamic therapy on hypoxic prostate cancer: a preclinical study on the Dunning R3327-AT2 rat tumor model.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Hypoxia; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug The

2013
The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:4

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Chloroquine; Deferoxamine; Drug Synergism

2013
A novel photodynamic therapy for drug-resistant prostate cancer cells using porphyrus envelope as a novel photosensitizer.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Drug Delivery Systems; Humans; Male; Photochemotherapy; Photo

2014
Photodynamic diagnosis of shed prostate cancer cells in voided urine treated with 5-aminolevulinic acid.
    BMC urology, 2014, Aug-03, Volume: 14

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biomarkers, Tumor; Feasibility Studies; Humans; Male;

2014
Accelerated migration and invasion of prostate cancer cells after a photodynamic therapy-like challenge: Role of nitric oxide.
    Nitric oxide : biology and chemistry, 2015, Sep-15, Volume: 49

    Topics: Cell Line, Tumor; Cell Movement; Humans; Male; Neoplasm Invasiveness; Nitric Oxide; Nitric Oxide Syn

2015
Latex carrier for improving protoporphyrin IX for photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 14

    Topics: Cell Line, Tumor; Cell Survival; Drug Stability; Humans; Hydrogen Bonding; Latex; Male; Molecular St

2016
Synthesis and conjugation of Sr
    Photodiagnosis and photodynamic therapy, 2016, Volume: 16

    Topics: Adsorption; Cell Line, Tumor; Cell Survival; Drug Compounding; Humans; Male; Metal Nanoparticles; Na

2016
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
    Scientific reports, 2016, 11-18, Volume: 6

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Hu

2016
Enhanced aggressiveness of bystander cells in an anti-tumor photodynamic therapy model: Role of nitric oxide produced by targeted cells.
    Free radical biology & medicine, 2017, Volume: 102

    Topics: Amidines; Apoptosis; Benzoates; Benzylamines; Bystander Effect; Cell Line, Tumor; Cell Movement; Cel

2017
Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives.
    Biochimica et biophysica acta. General subjects, 2017, Volume: 1861, Issue:7

    Topics: Animals; Apoptosis; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Male; Photochemotherapy; Photos

2017
Diamino acid derivatives of PpIX as potential photosensitizers for photodynamic therapy of squamous cell carcinoma and prostate cancer: in vitro studies.
    Journal of photochemistry and photobiology. B, Biology, 2009, Mar-03, Volume: 94, Issue:3

    Topics: Amino Acids, Diamino; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor;

2009
Intrinsic fluorescence of protoporphyrin IX from blood samples can yield information on the growth of prostate tumours.
    Journal of fluorescence, 2010, Volume: 20, Issue:6

    Topics: Animals; Biomarkers, Tumor; Calibration; Fluorescence; Humans; Male; Mice; Mice, Nude; Prostatic Neo

2010
Enhancement of blood porphyrin emission intensity with aminolevulinic acid administration: a new concept for photodynamic diagnosis of early prostate cancer.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:1

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cell Line, Tumor; Drug Synergism; Drug Therapy,

2011
Inhibition of cell growth induced by photosensitizer PP(Arg)2-mediated photodynamic therapy in human breast and prostate cell lines. Part I.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Hu

2011
Cytotoxicity of PP(Arg)(2)- and Hp(Arg)(2)-mediated photodynamic therapy and early stage of apoptosis induction in prostate carcinoma in vitro.
    Acta biochimica Polonica, 2011, Volume: 58, Issue:4

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Darkness; Hematoporphyrins; Humans; Male; Membrane Poten

2011
The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells.
    Urology, 2012, Volume: 80, Issue:6

    Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Chelating Agents; Ethylenediamines; Humans; Male;

2012
Study of protoporphyrin IX elimination by body excreta: a new noninvasive cancer diagnostic method?
    Journal of fluorescence, 2013, Volume: 23, Issue:1

    Topics: Animals; Cell Line, Tumor; Diagnostic Techniques and Procedures; Feces; Humans; Male; Mice; Prostati

2013
Differentiation enhances aminolevulinic acid-dependent photodynamic treatment of LNCaP prostate cancer cells.
    British journal of cancer, 2002, Nov-18, Volume: 87, Issue:11

    Topics: Aminolevulinic Acid; Cell Differentiation; Flow Cytometry; Humans; Male; Metribolone; Photochemother

2002
Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - in vivo experiments on the dunning rat tumor model.
    Urologia internationalis, 2004, Volume: 72, Issue:3

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Male; Photochemotherapy; Prostatic Neoplasms;

2004
Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells.
    British journal of cancer, 2006, Aug-21, Volume: 95, Issue:4

    Topics: Aminolevulinic Acid; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Sur

2006
In vivo quantification of fluorescent molecular markers in real-time by ratio imaging for diagnostic screening and image-guided surgery.
    Lasers in surgery and medicine, 2007, Volume: 39, Issue:7

    Topics: Diagnostic Imaging; Fluorescence; Humans; Indoles; Intraoperative Period; Male; Models, Theoretical;

2007
Interstitial photodynamic therapy in the canine prostate with disulfonated aluminum phthalocyanine and 5-aminolevulinic acid-induced protoporphyrin IX.
    The Prostate, 1997, Jul-01, Volume: 32, Issue:2

    Topics: Aminolevulinic Acid; Animals; Atrophy; Collagen; Dogs; Indoles; Lasers; Light; Male; Organometallic

1997
Hormonal modulation of the accumulation of 5-aminolevulinic acid-induced protoporphyrin and phototoxicity in prostate cancer cells.
    International journal of cancer, 1997, Sep-17, Volume: 72, Issue:6

    Topics: Aminolevulinic Acid; Animals; Blood; Cattle; Cell Division; Cell Survival; Culture Media; Dihydrotes

1997
Delta-aminolevulinic acid-mediated photosensitization of prostate cell lines: implication for photodynamic therapy of prostate cancer.
    The Prostate, 1998, Sep-01, Volume: 36, Issue:4

    Topics: Aminolevulinic Acid; Cell Survival; Humans; Male; Microscopy, Electron; Mitochondria; Photochemother

1998