protoporphyrin ix has been researched along with Porphyrias, Hepatic in 2 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Porphyrias, Hepatic: A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxidative liver injury during steatohepatitis results in aggregation and transglutaminase-2 (TG2)-mediated crosslinking of the keratin cytoplasmic intermediate filament proteins (IFs) to form Mallory-Denk body (MDB) inclusions." | 1.39 | Lamin aggregation is an early sensor of porphyria-induced liver injury. ( Ernst, SA; Griggs, NW; Herrmann, H; Kwan, R; Maitra, D; Omary, MB; Singla, A; Snider, NT, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singla, A | 1 |
| Griggs, NW | 1 |
| Kwan, R | 1 |
| Snider, NT | 1 |
| Maitra, D | 1 |
| Ernst, SA | 1 |
| Herrmann, H | 1 |
| Omary, MB | 1 |
| Dailey, TA | 1 |
| Dailey, HA | 1 |
2 other studies available for protoporphyrin ix and Porphyrias, Hepatic
| Article | Year |
|---|---|
Lamin aggregation is an early sensor of porphyria-induced liver injury.
Topics: Animals; Disease Models, Animal; Fatty Liver; Ferrochelatase; GTP-Binding Proteins; Hep G2 Cells; Hu | 2013 |
Expression, purification, and characteristics of mammalian protoporphyrinogen oxidase.
Topics: Amino Acid Sequence; Animals; Electron Transport; Escherichia coli; Flavoproteins; Humans; Kinetics; | 1997 |