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protoporphyrin ix and Porphyrias, Hepatic

protoporphyrin ix has been researched along with Porphyrias, Hepatic in 2 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Porphyrias, Hepatic: A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.

Research Excerpts

ExcerptRelevanceReference
"Oxidative liver injury during steatohepatitis results in aggregation and transglutaminase-2 (TG2)-mediated crosslinking of the keratin cytoplasmic intermediate filament proteins (IFs) to form Mallory-Denk body (MDB) inclusions."1.39Lamin aggregation is an early sensor of porphyria-induced liver injury. ( Ernst, SA; Griggs, NW; Herrmann, H; Kwan, R; Maitra, D; Omary, MB; Singla, A; Snider, NT, 2013)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Singla, A1
Griggs, NW1
Kwan, R1
Snider, NT1
Maitra, D1
Ernst, SA1
Herrmann, H1
Omary, MB1
Dailey, TA1
Dailey, HA1

Other Studies

2 other studies available for protoporphyrin ix and Porphyrias, Hepatic

ArticleYear
Lamin aggregation is an early sensor of porphyria-induced liver injury.
    Journal of cell science, 2013, Jul-15, Volume: 126, Issue:Pt 14

    Topics: Animals; Disease Models, Animal; Fatty Liver; Ferrochelatase; GTP-Binding Proteins; Hep G2 Cells; Hu

2013
Expression, purification, and characteristics of mammalian protoporphyrinogen oxidase.
    Methods in enzymology, 1997, Volume: 281

    Topics: Amino Acid Sequence; Animals; Electron Transport; Escherichia coli; Flavoproteins; Humans; Kinetics;

1997