protoporphyrin ix has been researched along with Porphyria in 22 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic pathway that lead to accumulation of heme precursors." | 5.01 | Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury. ( Bonkovsky, HL; Bragazzi Cunha, J; Elenbaas, JS; Maitra, D; Omary, MB; Shavit, JA, 2019) |
| "Porphyria was induced in vivo in mice using 3,5-diethoxycarbonyl-1,4-dihydrocollidine or in vitro by exposing human liver Huh7 cells and keratinocytes, or their lysates, to protoporphyrin-IX, other porphyrins, or to δ-aminolevulinic acid plus deferoxamine." | 3.91 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| "In a retrospective study, we measured heme precursors in the amniotic fluid (AF) of 51 healthy women, and 10 AF samples from pregnancies with either upper or lower intestinal atresia or ileus were also analyzed." | 3.88 | Characterization and origin of heme precursors in amniotic fluid: lessons from normal and pathological pregnancies. ( Allaf, B; Gil, S; Gouya, L; Lefebvre, T; Manceau, H; Muller, F; Peoc'h, K; Puy, H; Puy, V; Rosenblatt, J; Schmitt, CM, 2018) |
| "Each porphyria is described according to the enzyme in the heme biosynthetic sequence." | 2.39 | [Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria]. ( Harada, K; Kim, Y; Ohmori, S; Tomokuni, K, 1995) |
| "Porphyria is a group of genetic photodermatoses that cause too much porphyrin to accumulate in the blood, skin, and liver, resulting in skin photosensitivity and damage, liver disease, or potential liver failure." | 1.62 | Afterglow Amplification for Fast and Sensitive Detection of Porphyria in Whole Blood. ( Guo, L; Li, F; Su, Q; Su, X; Wang, T; Wen, Y; Xu, M; Yang, P; Yuan, H, 2021) |
| "Pretreatment with aminolevulinic acid or with protoporphyrin IX dramatically increased the light sensitivity of both TRPA1 and TRPV1 via generation of reactive oxygen species." | 1.43 | Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1. ( Babes, A; Filipovic, M; Fischer, MJ; Kichko, TI; Moparthi, L; Namer, B; Neacsu, C; Reeh, PW; Sauer, SK; Zygmunt, PM, 2016) |
| "Laboratory diagnosis of erythropoietic protoporphyria (EPP) requires a marked increase in total erythrocyte protoporphyrin (300-5000 μg/dL erythrocytes, reference interval <80 μg/dL) and a predominance (85%-100%) of metal-free protoporphyrin [normal, mostly zinc protoporphyrin (reference intervals for the zinc protoporphyrin proportion have not been established)]; plasma porphyrins are not always increased." | 1.42 | Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias. ( Anderson, KE; Balwani, M; Bissell, DM; Bloomer, JR; Bonkovsky, HL; Desnick, RJ; Gou, EW; Keel, S; Naik, H; Phillips, JD; Singal, AK; Wang, B, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (36.36) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, H | 1 |
| Guo, L | 1 |
| Su, Q | 1 |
| Su, X | 1 |
| Wen, Y | 1 |
| Wang, T | 1 |
| Yang, P | 1 |
| Xu, M | 1 |
| Li, F | 1 |
| Manceau, H | 1 |
| Puy, V | 1 |
| Schmitt, CM | 1 |
| Gil, S | 1 |
| Lefebvre, T | 1 |
| Allaf, B | 1 |
| Rosenblatt, J | 1 |
| Gouya, L | 1 |
| Puy, H | 1 |
| Muller, F | 1 |
| Peoc'h, K | 1 |
| Maitra, D | 2 |
| Carter, EL | 1 |
| Richardson, R | 1 |
| Rittié, L | 1 |
| Basrur, V | 1 |
| Zhang, H | 1 |
| Nesvizhskii, AI | 1 |
| Osawa, Y | 1 |
| Wolf, MW | 1 |
| Ragsdale, SW | 1 |
| Lehnert, N | 1 |
| Herrmann, H | 1 |
| Omary, MB | 3 |
| Bragazzi Cunha, J | 1 |
| Elenbaas, JS | 1 |
| Bonkovsky, HL | 2 |
| Shavit, JA | 1 |
| Gou, EW | 1 |
| Balwani, M | 1 |
| Bissell, DM | 1 |
| Bloomer, JR | 1 |
| Desnick, RJ | 1 |
| Naik, H | 1 |
| Phillips, JD | 1 |
| Singal, AK | 1 |
| Wang, B | 1 |
| Keel, S | 1 |
| Anderson, KE | 1 |
| Babes, A | 1 |
| Sauer, SK | 1 |
| Moparthi, L | 1 |
| Kichko, TI | 1 |
| Neacsu, C | 1 |
| Namer, B | 1 |
| Filipovic, M | 1 |
| Zygmunt, PM | 1 |
| Reeh, PW | 1 |
| Fischer, MJ | 1 |
| Hanada, S | 1 |
| Snider, NT | 1 |
| Brunt, EM | 1 |
| Hollenberg, PF | 1 |
| Ozaki, H | 1 |
| Zoghbi, SS | 1 |
| Hong, J | 1 |
| Verma, A | 1 |
| Pike, VW | 1 |
| Innis, RB | 1 |
| Fujita, M | 1 |
| Chavan, H | 1 |
| Krishnamurthy, P | 1 |
| SEARCY, RL | 1 |
| KOROTZER, JL | 1 |
| CRAIG, RG | 1 |
| BERGQUIST, LM | 1 |
| Viljoen, DJ | 1 |
| Cummins, R | 1 |
| Alexopoulos, J | 1 |
| Kramer, S | 2 |
| Stankiewicz, A | 1 |
| Mathews-Roth, MM | 2 |
| Harada, K | 1 |
| Ohmori, S | 1 |
| Kim, Y | 1 |
| Tomokuni, K | 1 |
| Van Brummelen, R | 1 |
| Myburgh, S | 1 |
| Bissbort, SH | 1 |
| Lavigne, JA | 1 |
| Nakatsu, K | 1 |
| Marks, GS | 1 |
| Cantoni, L | 1 |
| Rizzardini, M | 1 |
| Skorupska, M | 1 |
| Cagnotto, A | 1 |
| Codegoni, A | 1 |
| Pecora, N | 1 |
| Frigo, L | 1 |
| Ferrarese, C | 1 |
| Mennini, T | 1 |
| Minder, EI | 1 |
| Vuilleumier, JP | 1 |
| Vonderschmitt, DJ | 1 |
| Shehade, S | 1 |
| Ead, R | 1 |
| McDowell, D | 1 |
| Gebril, M | 1 |
| Weinkove, C | 1 |
| Orfanos, AP | 1 |
| Guthrie, R | 1 |
| Jinks, DC | 1 |
| Vollmer, DW | 1 |
| Siepker, LJ | 1 |
3 reviews available for protoporphyrin ix and Porphyria
| Article | Year |
|---|---|
Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury.
Topics: Animals; Carcinoma, Hepatocellular; Dermatitis, Phototoxic; Heme; Humans; Liver; Liver Neoplasms; Mi | 2019 |
[Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria].
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Porphyrias; Porphyrins; Protoporphyrins | 1995 |
Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adolescent; Adult; Animals; Bacteria; Bacterial Physiological Phen | 1986 |
19 other studies available for protoporphyrin ix and Porphyria
| Article | Year |
|---|---|
Afterglow Amplification for Fast and Sensitive Detection of Porphyria in Whole Blood.
Topics: Adamantane; Fluorescent Dyes; Humans; Limit of Detection; Porphyrias; Protoporphyrins; Quinolines; S | 2021 |
Characterization and origin of heme precursors in amniotic fluid: lessons from normal and pathological pregnancies.
Topics: Adult; Amniocentesis; Amniotic Fluid; Cell Differentiation; Coproporphyrins; Female; Heme; Humans; I | 2018 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; | 2019 |
Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Erythrocytes; Female; Fluoromet | 2015 |
Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neuro | 2016 |
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress.
Topics: Animals; Cytochrome P-450 Enzyme System; Female; Hepatocytes; Inclusion Bodies; Male; Mice; Microsom | 2010 |
In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography.
Topics: Acetamides; Animals; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Isoquinolines; Ma | 2010 |
Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR).
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Line; Cell S | 2012 |
Prestaining serum lipoproteins with protoporphyrin IX.
Topics: Humans; Lipoproteins; Porphyrias; Protoporphyrins | 1961 |
Protoporphyrinogen oxidase and ferrochelatase in porphyria variegata.
Topics: Adult; Ascorbic Acid; Chlorides; Female; Ferric Compounds; Ferrochelatase; Ferrous Compounds; Flavop | 1983 |
[Erythrocyte protoporphyrin IX in occupational exposure to asbestos].
Topics: Adult; Aged; Asbestos; Asbestosis; Erythrocytes; Female; Hemoglobins; Humans; Iron; Liver Diseases; | 1984 |
Treatment of erythropoietic protoporphyria with beta-carotene.
Topics: Age Factors; Animals; beta Carotene; Carotenoids; Dose-Response Relationship, Drug; Erythrocytes; Hu | 1984 |
The influence of porphyrogenic drugs on the glyoxalase enzymes.
Topics: Allylisopropylacetamide; Barbiturates; Chloramphenicol; Diazepam; Erythrocytes; Heme; Hemoglobins; H | 1993 |
Identification of human hepatic cytochrome P450 sources of N-alkylprotoporphyrin IX after interaction with porphyrinogenic xenobiotics, implications for detection of xenobiotic-induced porphyria in humans.
Topics: Animals; Cytochrome P-450 Enzyme System; Humans; Male; Microsomes, Liver; Porphyrias; Porphyrinogens | 2002 |
Hepatic protoporphyria is associated with a decrease in ligand binding for the mitochondrial benzodiazepine receptors in the liver.
Topics: 5-Aminolevulinate Synthetase; Adenosine Triphosphate; Animals; Binding Sites; Cerebral Cortex; Dicar | 1992 |
Prototype application of a robot in the clinical laboratory enabling fully automated quantification of fecal porphyrins.
Topics: Autoanalysis; Chromatography, High Pressure Liquid; Coproporphyrins; Feces; Humans; Porphyrias; Porp | 1992 |
Effects of oral zinc in erythropoietic protoporphyria.
Topics: Administration, Oral; Erythrocytes; Female; Humans; Male; Porphyrias; Protoporphyrins; Zinc | 1989 |
Simultaneous assay of zinc protoporphyrin and protoporphyrin IX in dried blood.
Topics: Adult; Anemia; Child; Humans; Infant; Lead Poisoning; Porphyrias; Porphyrins; Protoporphyrins; Speci | 1989 |
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both
Topics: Adult; Aminolevulinic Acid; Child; Edetic Acid; Ferrochelatase; Flavoproteins; Humans; Iron; Liver D | 1985 |