protoporphyrin ix has been researched along with Melanoma in 14 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, glioma, and colon cancer." | 7.96 | DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma. ( Doi, M; Hasegawa, T; Iwahashi, H; Moriyama, A; Nagasawa, S; Takahashi, J, 2020) |
| "Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD)." | 5.48 | Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells. ( Borissevitch, I; Ferreira, LP; Nicola, EMD; Reis, ER, 2018) |
| "With the application of CAP posttreatment, melanoma cell viability significantly decreased (80% were killed) compared to not using a light source (45% were killed) or using a UV light source (65% were killed)." | 5.46 | Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma. ( Geilich, BM; Keidar, M; Wang, M; Webster, TJ, 2017) |
| "Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, glioma, and colon cancer." | 3.96 | DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma. ( Doi, M; Hasegawa, T; Iwahashi, H; Moriyama, A; Nagasawa, S; Takahashi, J, 2020) |
| "Based on the observation that 5-aminolevulinic acid (ALA) induces the expression of heme oxygenase-1 (HO-1) in cultured melanoma cells, the role of HO-1 on the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) was examined." | 3.74 | Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy. ( Biesalski, HK; Flaccus, A; Frank, J; Lambert, C; Lornejad-Schäfer, MR; Schöffl, H, 2007) |
| " In the present study, piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid." | 3.73 | Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. ( Eom, SY; Kim, JA; Kim, KS; Kim, Y; Lee, SH; Min, KR, 2006) |
| "Malignant melanoma is an aggressive skin cancer with poor survival outcomes for patients diagnosed at an advanced stage." | 1.56 | Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma. ( Burnett, K; Callan, B; Callan, JF; Dhillon, SK; Matin, RN; McHale, AP; McKaig, T; Nesbitt, H; Porter, SL; Rizk, N; Sheng, Y; White, B, 2020) |
| "Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD)." | 1.48 | Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells. ( Borissevitch, I; Ferreira, LP; Nicola, EMD; Reis, ER, 2018) |
| "With the application of CAP posttreatment, melanoma cell viability significantly decreased (80% were killed) compared to not using a light source (45% were killed) or using a UV light source (65% were killed)." | 1.46 | Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma. ( Geilich, BM; Keidar, M; Wang, M; Webster, TJ, 2017) |
| "Metastatic skin cancer cells SKMEL-30 were treated by 5-ALA in dark and then they were irradiated by 90-femtosecond (fs) laser with different pulse powers for different durations." | 1.40 | Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: an efficient theranostic strategy to combat melanoma. ( Gündoğdu, Y; Kara, R; Kars, MD; Kepceoğlu, A; Kılıç, HŞ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| McEwan, C | 1 |
| Nesbitt, H | 2 |
| Nicholas, D | 1 |
| Kavanagh, ON | 1 |
| McKenna, K | 1 |
| Loan, P | 1 |
| Jack, IG | 1 |
| McHale, AP | 2 |
| Callan, JF | 2 |
| Dhillon, SK | 1 |
| Porter, SL | 1 |
| Rizk, N | 1 |
| Sheng, Y | 1 |
| McKaig, T | 1 |
| Burnett, K | 1 |
| White, B | 1 |
| Matin, RN | 1 |
| Callan, B | 1 |
| Hasegawa, T | 1 |
| Takahashi, J | 1 |
| Nagasawa, S | 1 |
| Doi, M | 1 |
| Moriyama, A | 1 |
| Iwahashi, H | 1 |
| da Silva, DB | 1 |
| da Silva, CL | 1 |
| Davanzo, NN | 1 |
| da Silva Souza, R | 1 |
| Correa, RJ | 1 |
| Tedesco, AC | 2 |
| Riemma Pierre, MB | 1 |
| Wang, M | 1 |
| Geilich, BM | 1 |
| Keidar, M | 1 |
| Webster, TJ | 1 |
| Reis, ER | 1 |
| Ferreira, LP | 1 |
| Nicola, EMD | 1 |
| Borissevitch, I | 1 |
| Fakhar-e-Alam, M | 1 |
| Kishwar, S | 1 |
| Willander, M | 1 |
| Kars, MD | 1 |
| Kara, R | 1 |
| Gündoğdu, Y | 1 |
| Kepceoğlu, A | 1 |
| Kılıç, HŞ | 1 |
| Woods, JA | 1 |
| Ferguson, JS | 1 |
| Kalra, S | 1 |
| Degabriele, A | 1 |
| Gardner, J | 1 |
| Logan, P | 1 |
| Ferguson, J | 1 |
| Shrestha, TB | 1 |
| Seo, GM | 1 |
| Basel, MT | 1 |
| Kalita, M | 1 |
| Wang, H | 1 |
| Villanueva, D | 1 |
| Pyle, M | 1 |
| Balivada, S | 1 |
| Rachakatla, RS | 1 |
| Shinogle, H | 1 |
| Thapa, PS | 1 |
| Moore, D | 1 |
| Troyer, DL | 1 |
| Bossmann, SH | 1 |
| Vena, FC | 1 |
| Turchiello, RF | 1 |
| Laville, I | 1 |
| Pigaglio, S | 1 |
| Blais, J | 1 |
| Kim, KS | 1 |
| Kim, JA | 1 |
| Eom, SY | 1 |
| Lee, SH | 1 |
| Min, KR | 1 |
| Kim, Y | 1 |
| Frank, J | 1 |
| Lornejad-Schäfer, MR | 1 |
| Schöffl, H | 1 |
| Flaccus, A | 1 |
| Lambert, C | 1 |
| Biesalski, HK | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
14 other studies available for protoporphyrin ix and Melanoma
| Article | Year |
|---|---|
Comparing the efficacy of photodynamic and sonodynamic therapy in non-melanoma and melanoma skin cancer.
Topics: Aminolevulinic Acid; Animals; Heterografts; Humans; Melanoma; Mice, SCID; Photochemotherapy; Skin Ne | 2016 |
Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Melanoma; | 2020 |
DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; DNA Breaks, Double-Stranded; Melanoma; Mice; Protopo | 2020 |
Protoporphyrin IX (PpIX) loaded PLGA nanoparticles for topical Photodynamic Therapy of melanoma cells.
Topics: Animals; Melanoma; Mice; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2021 |
Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma.
Topics: Cell Line, Tumor; Cell Survival; Drug Carriers; Humans; Melanoma; Nanoparticles; Photochemotherapy; | 2017 |
Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells.
Topics: Animals; Biological Transport; Cell Line, Tumor; Cell Survival; Darkness; Harderian Gland; Intracell | 2018 |
Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast.
Topics: Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Fibroblasts; Humans; Male; Melanoma; Nanowir | 2014 |
Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: an efficient theranostic strategy to combat melanoma.
Topics: Aged; Aminolevulinic Acid; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Fluorescence; Human | 2014 |
The phototoxicity of vemurafenib: An investigation of clinical monochromator phototesting and in vitro phototoxicity testing.
Topics: Cell Line; Chlorpromazine; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Dexamethaso | 2015 |
Stem cell-based photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Female; Fetal Blood; Imidazoles; Luci | 2012 |
5-aminolevulinic acid ester-induced protoporphyrin IX in a murine melanoma cell line.
Topics: Aminolevulinic Acid; Animals; Diffusion; Dose-Response Relationship, Drug; Magnetic Resonance Spectr | 2004 |
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line, Tumor; Cell Proliferation; Cyclic AMP Re | 2006 |
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Enzyme Inhibitors; Heme Oxygenase-1; Humans; Melanoma; Metall | 2007 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |