protoporphyrin ix has been researched along with Malignant Melanoma in 14 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, glioma, and colon cancer." | 7.96 | DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma. ( Doi, M; Hasegawa, T; Iwahashi, H; Moriyama, A; Nagasawa, S; Takahashi, J, 2020) |
| "Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD)." | 5.48 | Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells. ( Borissevitch, I; Ferreira, LP; Nicola, EMD; Reis, ER, 2018) |
| "With the application of CAP posttreatment, melanoma cell viability significantly decreased (80% were killed) compared to not using a light source (45% were killed) or using a UV light source (65% were killed)." | 5.46 | Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma. ( Geilich, BM; Keidar, M; Wang, M; Webster, TJ, 2017) |
| "Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, glioma, and colon cancer." | 3.96 | DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma. ( Doi, M; Hasegawa, T; Iwahashi, H; Moriyama, A; Nagasawa, S; Takahashi, J, 2020) |
| "Based on the observation that 5-aminolevulinic acid (ALA) induces the expression of heme oxygenase-1 (HO-1) in cultured melanoma cells, the role of HO-1 on the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) was examined." | 3.74 | Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy. ( Biesalski, HK; Flaccus, A; Frank, J; Lambert, C; Lornejad-Schäfer, MR; Schöffl, H, 2007) |
| " In the present study, piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid." | 3.73 | Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. ( Eom, SY; Kim, JA; Kim, KS; Kim, Y; Lee, SH; Min, KR, 2006) |
| "Malignant melanoma is an aggressive skin cancer with poor survival outcomes for patients diagnosed at an advanced stage." | 1.56 | Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma. ( Burnett, K; Callan, B; Callan, JF; Dhillon, SK; Matin, RN; McHale, AP; McKaig, T; Nesbitt, H; Porter, SL; Rizk, N; Sheng, Y; White, B, 2020) |
| "Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD)." | 1.48 | Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells. ( Borissevitch, I; Ferreira, LP; Nicola, EMD; Reis, ER, 2018) |
| "With the application of CAP posttreatment, melanoma cell viability significantly decreased (80% were killed) compared to not using a light source (45% were killed) or using a UV light source (65% were killed)." | 1.46 | Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma. ( Geilich, BM; Keidar, M; Wang, M; Webster, TJ, 2017) |
| "Metastatic skin cancer cells SKMEL-30 were treated by 5-ALA in dark and then they were irradiated by 90-femtosecond (fs) laser with different pulse powers for different durations." | 1.40 | Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: an efficient theranostic strategy to combat melanoma. ( Gündoğdu, Y; Kara, R; Kars, MD; Kepceoğlu, A; Kılıç, HŞ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| McEwan, C | 1 |
| Nesbitt, H | 2 |
| Nicholas, D | 1 |
| Kavanagh, ON | 1 |
| McKenna, K | 1 |
| Loan, P | 1 |
| Jack, IG | 1 |
| McHale, AP | 2 |
| Callan, JF | 2 |
| Dhillon, SK | 1 |
| Porter, SL | 1 |
| Rizk, N | 1 |
| Sheng, Y | 1 |
| McKaig, T | 1 |
| Burnett, K | 1 |
| White, B | 1 |
| Matin, RN | 1 |
| Callan, B | 1 |
| Hasegawa, T | 1 |
| Takahashi, J | 1 |
| Nagasawa, S | 1 |
| Doi, M | 1 |
| Moriyama, A | 1 |
| Iwahashi, H | 1 |
| da Silva, DB | 1 |
| da Silva, CL | 1 |
| Davanzo, NN | 1 |
| da Silva Souza, R | 1 |
| Correa, RJ | 1 |
| Tedesco, AC | 2 |
| Riemma Pierre, MB | 1 |
| Wang, M | 1 |
| Geilich, BM | 1 |
| Keidar, M | 1 |
| Webster, TJ | 1 |
| Reis, ER | 1 |
| Ferreira, LP | 1 |
| Nicola, EMD | 1 |
| Borissevitch, I | 1 |
| Fakhar-e-Alam, M | 1 |
| Kishwar, S | 1 |
| Willander, M | 1 |
| Kars, MD | 1 |
| Kara, R | 1 |
| Gündoğdu, Y | 1 |
| Kepceoğlu, A | 1 |
| Kılıç, HŞ | 1 |
| Woods, JA | 1 |
| Ferguson, JS | 1 |
| Kalra, S | 1 |
| Degabriele, A | 1 |
| Gardner, J | 1 |
| Logan, P | 1 |
| Ferguson, J | 1 |
| Shrestha, TB | 1 |
| Seo, GM | 1 |
| Basel, MT | 1 |
| Kalita, M | 1 |
| Wang, H | 1 |
| Villanueva, D | 1 |
| Pyle, M | 1 |
| Balivada, S | 1 |
| Rachakatla, RS | 1 |
| Shinogle, H | 1 |
| Thapa, PS | 1 |
| Moore, D | 1 |
| Troyer, DL | 1 |
| Bossmann, SH | 1 |
| Vena, FC | 1 |
| Turchiello, RF | 1 |
| Laville, I | 1 |
| Pigaglio, S | 1 |
| Blais, J | 1 |
| Kim, KS | 1 |
| Kim, JA | 1 |
| Eom, SY | 1 |
| Lee, SH | 1 |
| Min, KR | 1 |
| Kim, Y | 1 |
| Frank, J | 1 |
| Lornejad-Schäfer, MR | 1 |
| Schöffl, H | 1 |
| Flaccus, A | 1 |
| Lambert, C | 1 |
| Biesalski, HK | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
14 other studies available for protoporphyrin ix and Malignant Melanoma
| Article | Year |
|---|---|
Comparing the efficacy of photodynamic and sonodynamic therapy in non-melanoma and melanoma skin cancer.
Topics: Aminolevulinic Acid; Animals; Heterografts; Humans; Melanoma; Mice, SCID; Photochemotherapy; Skin Ne | 2016 |
Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Melanoma; | 2020 |
DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; DNA Breaks, Double-Stranded; Melanoma; Mice; Protopo | 2020 |
Protoporphyrin IX (PpIX) loaded PLGA nanoparticles for topical Photodynamic Therapy of melanoma cells.
Topics: Animals; Melanoma; Mice; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2021 |
Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma.
Topics: Cell Line, Tumor; Cell Survival; Drug Carriers; Humans; Melanoma; Nanoparticles; Photochemotherapy; | 2017 |
Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells.
Topics: Animals; Biological Transport; Cell Line, Tumor; Cell Survival; Darkness; Harderian Gland; Intracell | 2018 |
Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast.
Topics: Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Fibroblasts; Humans; Male; Melanoma; Nanowir | 2014 |
Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: an efficient theranostic strategy to combat melanoma.
Topics: Aged; Aminolevulinic Acid; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Fluorescence; Human | 2014 |
The phototoxicity of vemurafenib: An investigation of clinical monochromator phototesting and in vitro phototoxicity testing.
Topics: Cell Line; Chlorpromazine; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Dexamethaso | 2015 |
Stem cell-based photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Female; Fetal Blood; Imidazoles; Luci | 2012 |
5-aminolevulinic acid ester-induced protoporphyrin IX in a murine melanoma cell line.
Topics: Aminolevulinic Acid; Animals; Diffusion; Dose-Response Relationship, Drug; Magnetic Resonance Spectr | 2004 |
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line, Tumor; Cell Proliferation; Cyclic AMP Re | 2006 |
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Enzyme Inhibitors; Heme Oxygenase-1; Humans; Melanoma; Metall | 2007 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |