protoporphyrin ix has been researched along with Leukemia in 11 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human adenocarcinoma cells of the line WiDr and human leukemia T cells of the line Jurkat were incubated with 5-aminolevulinic acid and found to produce protoporphyrin IX (PpIX)." | 3.71 | Transfer of protoporphyrin IX between cells. ( Ma, LW; Moan, J; Stokke, T, 2002) |
| "To verify if photodynamic therapy (PDT) could overcome multidrug resistance (MDR) when it it applied to eradicate minimal residual disease in patients with leukemia, we investigated the fluorescence kinetics of 5-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) and the effect of subsequent photodynamic therapy on MDR leukemia cells, which express P-glycoprotein (P-gp), as well as on their parent cells." | 3.71 | 5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells. ( Hashimoto, K; Li, W; Ohnishi, K; Ohno, R; Yamada, I; Zhang, WJ, 2001) |
| " Erythroid differentiation of human leukemia cell line K562 is induced by hemin or protoporphyrin IX in the presence of fetal bovine serum (FBS)." | 3.69 | Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells. ( Hashimoto, Y; Iwasaki, S; Kagechika, H; Nakajima, O; Shudo, K, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Su, X | 1 |
| Wang, X | 1 |
| Leung, AW | 1 |
| Xu, C | 1 |
| Wang, P | 1 |
| Liu, Q | 1 |
| Diez, B | 1 |
| Cordo Russo, R | 1 |
| Teijo, MJ | 1 |
| Hajos, S | 1 |
| Batlle, A | 1 |
| Fukuda, H | 1 |
| Moan, J | 1 |
| Ma, LW | 1 |
| Stokke, T | 1 |
| Louache, F | 2 |
| Testa, U | 2 |
| Pelicci, P | 1 |
| Thomopoulos, P | 2 |
| Titeux, M | 2 |
| Rochant, H | 2 |
| Nakajima, O | 1 |
| Kagechika, H | 1 |
| Shudo, K | 1 |
| Hashimoto, Y | 1 |
| Iwasaki, S | 1 |
| Grebenová, D | 1 |
| Cajthamlová, H | 2 |
| Bartosová, J | 2 |
| Marinov, J | 1 |
| Klamová, H | 1 |
| Fuchs, O | 1 |
| Hrkal, Z | 3 |
| Belicková, M | 1 |
| Bruchová, H | 1 |
| Brdicka, R | 1 |
| Rebeiz, N | 1 |
| Arkins, S | 1 |
| Kelley, KW | 1 |
| Durack, G | 1 |
| Rebeiz, CA | 1 |
| Li, W | 1 |
| Zhang, WJ | 1 |
| Ohnishi, K | 1 |
| Yamada, I | 1 |
| Ohno, R | 1 |
| Hashimoto, K | 1 |
11 other studies available for protoporphyrin ix and Leukemia
| Article | Year |
|---|---|
Cytotoxic effect of protoporphyrin IX to human Leukemia U937 cells under ultrasonic irradiation.
Topics: Acetylcysteine; Apoptosis; DNA; DNA Fragmentation; Humans; Leukemia; Membrane Potential, Mitochondri | 2014 |
Ros production by endogenously generated Protoporphyrin IX in murine leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Leukemia; Memb | 2009 |
Transfer of protoporphyrin IX between cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Colonic Neoplasms; Humans | 2002 |
Regulation of transferrin receptors in human hematopoietic cell lines.
Topics: Antibodies, Monoclonal; Apoproteins; Cell Division; Cell Line; Heme; Humans; In Vitro Techniques; Ir | 1984 |
[Modulation of the expression of transferrin receptors by iron, hemin and protoporphyrin IX].
Topics: Animals; Cell Line; Cells, Cultured; Heme; Hemin; Humans; Iron; Leukemia; Porphyrins; Protoporphyrin | 1983 |
Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.
Topics: Cell Differentiation; Charcoal; Culture Media; Erythrocytes; Gene Expression; Genes, myc; Hemin; Hum | 1995 |
Selective destruction of leukaemic cells by photo-activation of 5-aminolaevulinic acid-induced protoporphyrin-IX.
Topics: Aminolevulinic Acid; Bone Marrow Cells; Cell Division; Cell Survival; Hematopoietic Stem Cells; HL-6 | 1998 |
Genes involved in the destruction of leukaemic cells by induced photosensitivity.
Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; DNA, Complementary; Gene Expression Profiling; Gene E | 2000 |
Accumulation of protoporphyrin-IX (PpIX) in leukemic cell lines following induction by 5-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Animals; Cattle; Culture Media; Ferrochelatase; HL-60 Cells; Humans; Jurkat Cel | 2000 |
Modulator of heme biosynthesis induces apoptosis in leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Cycle; Cell Division; Cell Membrane Permeability; Cell | 2001 |
5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells.
Topics: Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dermatitis, | 2001 |