protoporphyrin ix has been researched along with Hepatocellular Carcinoma in 17 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)." | 7.88 | Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018) |
| "Backgtound/Aim: Since hepatocellular carcinoma (HCC) has a high recurrence rate, accurate diagnosis of its location and curative resection is important to improve survival." | 5.43 | Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid. ( Fujiwara, H; Harada, K; Ichikawa, D; Ikoma, H; Kamada, Y; Morimura, R; Murayama, Y; Nishimura, M; Okamoto, K; Otsuji, E, 2016) |
| "Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic pathway that lead to accumulation of heme precursors." | 5.01 | Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury. ( Bonkovsky, HL; Bragazzi Cunha, J; Elenbaas, JS; Maitra, D; Omary, MB; Shavit, JA, 2019) |
| "Porphyria was induced in vivo in mice using 3,5-diethoxycarbonyl-1,4-dihydrocollidine or in vitro by exposing human liver Huh7 cells and keratinocytes, or their lysates, to protoporphyrin-IX, other porphyrins, or to δ-aminolevulinic acid plus deferoxamine." | 3.91 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| " This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)." | 3.88 | Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018) |
| "To examine the efficacy and mechanism of delta- or 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on a human hepatocellular carcinoma cell line." | 3.74 | Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell. ( Ho, RJ; Huang, Z; Wong, CK; Yow, CM, 2007) |
| "Isoniazid has recently been reported to upregulate Alas1 but downregulate Fech protein levels in mice; however, the mechanism by which isoniazid mediates disruption of heme synthesis has been unclear." | 1.51 | The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. ( Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L, 2019) |
| "Thus, hepatocellular carcinoma triggers high levels of serum TrxR that are not paralleled by ALT, and TrxR enzyme activity in serum is counteracted by several different mechanisms." | 1.43 | Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. ( Arnér, ESJ; Cheng, Q; Fass, D; Ilani, T; Merrill, GF; Wang, Y; Zhang, J; Zhang, L, 2016) |
| "Backgtound/Aim: Since hepatocellular carcinoma (HCC) has a high recurrence rate, accurate diagnosis of its location and curative resection is important to improve survival." | 1.43 | Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid. ( Fujiwara, H; Harada, K; Ichikawa, D; Ikoma, H; Kamada, Y; Morimura, R; Murayama, Y; Nishimura, M; Okamoto, K; Otsuji, E, 2016) |
| "Protoporphyrin IX (PPIX) has been used for photodynamic therapy." | 1.42 | Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents. ( Heo, MJ; Kim, SG; Lee, CG; Lee, JM; Yang, YM, 2015) |
| "5-ALA fluorescence was detected in all hepatocellular carcinoma cases with serosa invasion." | 1.40 | Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience. ( Hayashi, M; Hirokawa, F; Inoue, Y; Komeda, K; Tanaka, R; Uchiyama, K, 2014) |
| "Cu2+ toxicity was examined in two hepatocellular carcinoma cell lines, HepG2 and Hep3B, with Hep3B cells containing an integrated hepatitis B virus genome." | 1.35 | Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease. ( Babushkin, T; Hait-Darshan, R; Malik, Z, 2009) |
| "Chronic venous ulcers are characterized by chronic inflammation." | 1.32 | Heme-scavenging role of alpha1-microglobulin in chronic ulcers. ( Akerström, B; Allhorn, M; Lundqvist, K; Schmidtchen, A, 2003) |
| "5-Aminolevulinic acid (ALA) is a precursor to heme synthesis pathway and currently used to induce endogenous protoporphyrin IX (PpIX, a potent photosensitizer) for photodynamic therapy of cancer." | 1.31 | Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abo-Zeid, MAM | 1 |
| Abo-Elfadl, MT | 1 |
| Mostafa, SM | 1 |
| Brewer, CT | 1 |
| Yang, L | 1 |
| Edwards, A | 1 |
| Lu, Y | 1 |
| Low, J | 1 |
| Wu, J | 1 |
| Lee, RE | 1 |
| Chen, T | 1 |
| Maitra, D | 2 |
| Carter, EL | 1 |
| Richardson, R | 1 |
| Rittié, L | 1 |
| Basrur, V | 1 |
| Zhang, H | 1 |
| Nesvizhskii, AI | 1 |
| Osawa, Y | 1 |
| Wolf, MW | 1 |
| Ragsdale, SW | 1 |
| Lehnert, N | 1 |
| Herrmann, H | 1 |
| Omary, MB | 2 |
| Bragazzi Cunha, J | 1 |
| Elenbaas, JS | 1 |
| Bonkovsky, HL | 1 |
| Shavit, JA | 1 |
| Inoue, Y | 1 |
| Tanaka, R | 1 |
| Komeda, K | 1 |
| Hirokawa, F | 1 |
| Hayashi, M | 1 |
| Uchiyama, K | 1 |
| Laafi, J | 1 |
| Homedan, C | 1 |
| Jacques, C | 1 |
| Gueguen, N | 1 |
| Schmitt, C | 1 |
| Puy, H | 1 |
| Reynier, P | 1 |
| Carmen Martinez, M | 1 |
| Malthièry, Y | 1 |
| Lee, JM | 1 |
| Heo, MJ | 1 |
| Lee, CG | 1 |
| Yang, YM | 1 |
| Kim, SG | 1 |
| Zhang, L | 2 |
| Cheng, Q | 1 |
| Wang, Y | 2 |
| Merrill, GF | 1 |
| Ilani, T | 1 |
| Fass, D | 1 |
| Arnér, ESJ | 1 |
| Zhang, J | 1 |
| Nishimura, M | 1 |
| Murayama, Y | 1 |
| Harada, K | 1 |
| Kamada, Y | 1 |
| Morimura, R | 1 |
| Ikoma, H | 1 |
| Ichikawa, D | 1 |
| Fujiwara, H | 1 |
| Okamoto, K | 1 |
| Otsuji, E | 1 |
| Hait-Darshan, R | 1 |
| Babushkin, T | 1 |
| Malik, Z | 1 |
| Wang, XB | 1 |
| Liu, QH | 1 |
| Mi, N | 1 |
| Wang, P | 2 |
| Tang, W | 1 |
| Zhao, XH | 1 |
| Li, XJ | 1 |
| Wang, X | 1 |
| Cheng, X | 1 |
| Liu, Q | 1 |
| Ren, QG | 1 |
| Wu, SM | 1 |
| Peng, Q | 1 |
| Chen, JY | 1 |
| Otake, M | 1 |
| Nishiwaki, M | 1 |
| Kobayashi, Y | 1 |
| Baba, S | 1 |
| Kohno, E | 1 |
| Kawasaki, T | 1 |
| Fujise, Y | 1 |
| Nakamura, H | 1 |
| Allhorn, M | 1 |
| Lundqvist, K | 1 |
| Schmidtchen, A | 1 |
| Akerström, B | 1 |
| Yow, CM | 1 |
| Wong, CK | 1 |
| Huang, Z | 1 |
| Ho, RJ | 1 |
| Vonarx-Coinsman, V | 1 |
| Foultier, MT | 1 |
| de Brito, LX | 1 |
| Morlet, L | 1 |
| Gouyette, A | 1 |
| Patrice, T | 1 |
1 review available for protoporphyrin ix and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury.
Topics: Animals; Carcinoma, Hepatocellular; Dermatitis, Phototoxic; Heme; Humans; Liver; Liver Neoplasms; Mi | 2019 |
16 other studies available for protoporphyrin ix and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines.
Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Hepatocellular; DNA Damage; Hep G2 | 2018 |
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells | 2019 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; | 2019 |
Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience.
Topics: Aged; Aminolevulinic Acid; Anastomotic Leak; Carcinoma, Hepatocellular; Color; Colorectal Neoplasms; | 2014 |
Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Antioxidants; Blotting, Western; Carcinoma, Hepatocellu | 2014 |
Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Carcinoma, Hepatocellular; C | 2015 |
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Topics: Alanine Transaminase; Aldehydes; Animals; Antineoplastic Agents; Auranofin; Carboplatin; Carcinoma, | 2016 |
Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid.
Topics: Aged; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Embolization, Thera | 2016 |
Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease.
Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Line, Tumor; C | 2009 |
Sonodynamically induced apoptosis by protoporphyrin IX on hepatoma-22 cells in vitro.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Combined Modality Therapy; Dose-Res | 2010 |
Sonodynamically induced anti-tumor effect with protoporphyrin IX on hepatoma-22 solid tumor.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Liver Neoplasms; Mice; | 2011 |
Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Photochemotherapy; Photosen | 2002 |
Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma.
Topics: Alkylating Agents; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylni | 2003 |
Heme-scavenging role of alpha1-microglobulin in chronic ulcers.
Topics: Alpha-Globulins; Body Fluids; Carbon Radioisotopes; Carcinoma, Hepatocellular; Chronic Disease; Derm | 2003 |
Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug The | 2007 |
HepG2 human hepatocarcinoma cells: an experimental model for photosensitization by endogenous porphyrins.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Flow Cytometry; Hematoporphyrins; Humans; Lasers; Mo | 1995 |