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protoporphyrin ix and Hepatocellular Carcinoma

protoporphyrin ix has been researched along with Hepatocellular Carcinoma in 17 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Research Excerpts

ExcerptRelevanceReference
" This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)."7.88Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018)
"Backgtound/Aim: Since hepatocellular carcinoma (HCC) has a high recurrence rate, accurate diagnosis of its location and curative resection is important to improve survival."5.43Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid. ( Fujiwara, H; Harada, K; Ichikawa, D; Ikoma, H; Kamada, Y; Morimura, R; Murayama, Y; Nishimura, M; Okamoto, K; Otsuji, E, 2016)
"Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic pathway that lead to accumulation of heme precursors."5.01Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury. ( Bonkovsky, HL; Bragazzi Cunha, J; Elenbaas, JS; Maitra, D; Omary, MB; Shavit, JA, 2019)
"Porphyria was induced in vivo in mice using 3,5-diethoxycarbonyl-1,4-dihydrocollidine or in vitro by exposing human liver Huh7 cells and keratinocytes, or their lysates, to protoporphyrin-IX, other porphyrins, or to δ-aminolevulinic acid plus deferoxamine."3.91Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019)
" This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)."3.88Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018)
"To examine the efficacy and mechanism of delta- or 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on a human hepatocellular carcinoma cell line."3.74Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell. ( Ho, RJ; Huang, Z; Wong, CK; Yow, CM, 2007)
"Isoniazid has recently been reported to upregulate Alas1 but downregulate Fech protein levels in mice; however, the mechanism by which isoniazid mediates disruption of heme synthesis has been unclear."1.51The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. ( Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L, 2019)
"Thus, hepatocellular carcinoma triggers high levels of serum TrxR that are not paralleled by ALT, and TrxR enzyme activity in serum is counteracted by several different mechanisms."1.43Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. ( Arnér, ESJ; Cheng, Q; Fass, D; Ilani, T; Merrill, GF; Wang, Y; Zhang, J; Zhang, L, 2016)
"Backgtound/Aim: Since hepatocellular carcinoma (HCC) has a high recurrence rate, accurate diagnosis of its location and curative resection is important to improve survival."1.43Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid. ( Fujiwara, H; Harada, K; Ichikawa, D; Ikoma, H; Kamada, Y; Morimura, R; Murayama, Y; Nishimura, M; Okamoto, K; Otsuji, E, 2016)
"Protoporphyrin IX (PPIX) has been used for photodynamic therapy."1.42Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents. ( Heo, MJ; Kim, SG; Lee, CG; Lee, JM; Yang, YM, 2015)
"5-ALA fluorescence was detected in all hepatocellular carcinoma cases with serosa invasion."1.40Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience. ( Hayashi, M; Hirokawa, F; Inoue, Y; Komeda, K; Tanaka, R; Uchiyama, K, 2014)
"Cu2+ toxicity was examined in two hepatocellular carcinoma cell lines, HepG2 and Hep3B, with Hep3B cells containing an integrated hepatitis B virus genome."1.35Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease. ( Babushkin, T; Hait-Darshan, R; Malik, Z, 2009)
"Chronic venous ulcers are characterized by chronic inflammation."1.32Heme-scavenging role of alpha1-microglobulin in chronic ulcers. ( Akerström, B; Allhorn, M; Lundqvist, K; Schmidtchen, A, 2003)
"5-Aminolevulinic acid (ALA) is a precursor to heme synthesis pathway and currently used to induce endogenous protoporphyrin IX (PpIX, a potent photosensitizer) for photodynamic therapy of cancer."1.31Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM, 2002)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's5 (29.41)29.6817
2010's11 (64.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abo-Zeid, MAM1
Abo-Elfadl, MT1
Mostafa, SM1
Brewer, CT1
Yang, L1
Edwards, A1
Lu, Y1
Low, J1
Wu, J1
Lee, RE1
Chen, T1
Maitra, D2
Carter, EL1
Richardson, R1
Rittié, L1
Basrur, V1
Zhang, H1
Nesvizhskii, AI1
Osawa, Y1
Wolf, MW1
Ragsdale, SW1
Lehnert, N1
Herrmann, H1
Omary, MB2
Bragazzi Cunha, J1
Elenbaas, JS1
Bonkovsky, HL1
Shavit, JA1
Inoue, Y1
Tanaka, R1
Komeda, K1
Hirokawa, F1
Hayashi, M1
Uchiyama, K1
Laafi, J1
Homedan, C1
Jacques, C1
Gueguen, N1
Schmitt, C1
Puy, H1
Reynier, P1
Carmen Martinez, M1
Malthièry, Y1
Lee, JM1
Heo, MJ1
Lee, CG1
Yang, YM1
Kim, SG1
Zhang, L2
Cheng, Q1
Wang, Y2
Merrill, GF1
Ilani, T1
Fass, D1
Arnér, ESJ1
Zhang, J1
Nishimura, M1
Murayama, Y1
Harada, K1
Kamada, Y1
Morimura, R1
Ikoma, H1
Ichikawa, D1
Fujiwara, H1
Okamoto, K1
Otsuji, E1
Hait-Darshan, R1
Babushkin, T1
Malik, Z1
Wang, XB1
Liu, QH1
Mi, N1
Wang, P2
Tang, W1
Zhao, XH1
Li, XJ1
Wang, X1
Cheng, X1
Liu, Q1
Ren, QG1
Wu, SM1
Peng, Q1
Chen, JY1
Otake, M1
Nishiwaki, M1
Kobayashi, Y1
Baba, S1
Kohno, E1
Kawasaki, T1
Fujise, Y1
Nakamura, H1
Allhorn, M1
Lundqvist, K1
Schmidtchen, A1
Akerström, B1
Yow, CM1
Wong, CK1
Huang, Z1
Ho, RJ1
Vonarx-Coinsman, V1
Foultier, MT1
de Brito, LX1
Morlet, L1
Gouyette, A1
Patrice, T1

Reviews

1 review available for protoporphyrin ix and Hepatocellular Carcinoma

ArticleYear
Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 8, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Dermatitis, Phototoxic; Heme; Humans; Liver; Liver Neoplasms; Mi

2019

Other Studies

16 other studies available for protoporphyrin ix and Hepatocellular Carcinoma

ArticleYear
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 21

    Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Hepatocellular; DNA Damage; Hep G2

2018
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 03-01, Volume: 168, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells

2019
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 8, Issue:4

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes;

2019
Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience.
    World journal of surgery, 2014, Volume: 38, Issue:7

    Topics: Aged; Aminolevulinic Acid; Anastomotic Leak; Carcinoma, Hepatocellular; Color; Colorectal Neoplasms;

2014
Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells.
    Biochimie, 2014, Volume: 106

    Topics: Adenosine Triphosphate; Aminolevulinic Acid; Antioxidants; Blotting, Western; Carcinoma, Hepatocellu

2014
Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents.
    Oncotarget, 2015, Feb-28, Volume: 6, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Carcinoma, Hepatocellular; C

2015
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
    Free radical biology & medicine, 2016, Volume: 99

    Topics: Alanine Transaminase; Aldehydes; Animals; Antineoplastic Agents; Auranofin; Carboplatin; Carcinoma,

2016
Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid.
    Anticancer research, 2016, Volume: 36, Issue:9

    Topics: Aged; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Embolization, Thera

2016
Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2009, Volume: 28, Issue:3

    Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Line, Tumor; C

2009
Sonodynamically induced apoptosis by protoporphyrin IX on hepatoma-22 cells in vitro.
    Ultrasound in medicine & biology, 2010, Volume: 36, Issue:4

    Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Combined Modality Therapy; Dose-Res

2010
Sonodynamically induced anti-tumor effect with protoporphyrin IX on hepatoma-22 solid tumor.
    Ultrasonics, 2011, Volume: 51, Issue:5

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Liver Neoplasms; Mice;

2011
Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells.
    Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 2002, Volume: 34, Issue:5

    Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Photochemotherapy; Photosen

2002
Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma.
    British journal of cancer, 2003, Aug-18, Volume: 89, Issue:4

    Topics: Alkylating Agents; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylni

2003
Heme-scavenging role of alpha1-microglobulin in chronic ulcers.
    The Journal of investigative dermatology, 2003, Volume: 121, Issue:3

    Topics: Alpha-Globulins; Body Fluids; Carbon Radioisotopes; Carcinoma, Hepatocellular; Chronic Disease; Derm

2003
Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell.
    Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:2

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug The

2007
HepG2 human hepatocarcinoma cells: an experimental model for photosensitization by endogenous porphyrins.
    Journal of photochemistry and photobiology. B, Biology, 1995, Volume: 30, Issue:2-3

    Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Flow Cytometry; Hematoporphyrins; Humans; Lasers; Mo

1995