Page last updated: 2024-11-03

protoporphyrin ix and Glioma

protoporphyrin ix has been researched along with Glioma in 84 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented."9.24A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017)
"5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas."9.055-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020)
"5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection."8.12Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022)
"5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas."8.12Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022)
"5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection."8.12Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022)
"5-Aminolevulinic Acid (5-ALA) photodiagnosis (PD) is an effective method to detect residual tumors during glioma surgery."8.02Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells. ( Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D, 2021)
"Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration."7.91Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019)
"Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors."7.91Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019)
"Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas."7.88Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018)
"OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas."7.88Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018)
"5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker."7.855-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017)
" 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas."7.85Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017)
"Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival."7.81Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015)
"We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells."7.80[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014)
"Among glioma treatment strategies, 5-aminolevulinic acid (5-ALA)-based fluorescence-guided resection (FGR) and photodynamic therapy (PDT) have been used as effective novel approaches against malignant glioma."7.79Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S, 2013)
"These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas."7.78¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012)
"5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours."7.78Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012)
"In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas."7.78Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012)
"The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated."7.74Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007)
"Malignant gliomas are locally invasive tumors that offer a poor prognosis."6.53Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016)
"This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy."5.40Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014)
"5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor."5.32Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003)
"OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination."5.27Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018)
"The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented."5.24A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017)
" Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)."5.15Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011)
"Oral application of 20 mg/kg body weight of 5-aminolevulinic acid (ALA) leads to a highly specific accumulation of fluorescent Protoporphyrin IX (PPIX) in malignant glioma tissue."5.12ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. ( Beck, T; Kreth, FW; Meinel, T; Pongratz, T; Stepp, H; Stummer, W; Tonn, JCh, 2007)
"5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas."5.055-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020)
"The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade."4.88Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. ( Colditz, MJ; Jeffree, RL; Leyen, Kv, 2012)
"Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas."4.85[Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009)
"5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas."4.12Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022)
"5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection."4.12Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022)
"5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection."4.12Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022)
"This study evaluated the use of molecular imaging of fluorescent glucose analog 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) as a discriminatory marker for intraoperative tumor border identification in a murine glioma model."4.02Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. ( Bardonova, L; Belykh, E; Eschbacher, JM; George, LL; Georges, JF; Healey, DR; Jubran, JH; Mehta, S; Nakaji, P; Preul, MC; Quarles, CC; Scheck, AC, 2021)
"Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse."4.025-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021)
"5-Aminolevulinic Acid (5-ALA) photodiagnosis (PD) is an effective method to detect residual tumors during glioma surgery."4.02Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells. ( Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D, 2021)
"Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration."3.91Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019)
"Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors."3.91Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019)
"5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients' outcome."3.91Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors. ( Brentrup, A; Kaneko, S; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W; Suero Molina, E, 2019)
"Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas."3.88Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching. ( Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K, 2018)
"Mapping the optical absorption and scattering properties of tissues using spatial frequency-domain imaging (SFDI) enhances quantitative fluorescence imaging of protoporphyrin IX (PpIX) in gliomas in the preclinical setting."3.88Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection. ( Olson, J; Paulsen, K; Roberts, DW; Sibai, M; Wilson, BC; Wirth, D, 2018)
"Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas."3.88Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018)
"OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas."3.88Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018)
"Fluorescence image guided surgery (FIGS) with 5-aminolevulinic acid for malignant gliomas improves surgical outcome."3.85Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid. ( Fukumura, M; Furuse, M; Ikeda, N; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Matsuda, F; Nonoguchi, N; Saito, K; Sato, T; Sugano, T; Takeuchi, K, 2017)
" 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas."3.85Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017)
"Fluorescence guided surgery (FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual contrast between normal and malignant tissue during resection of high grade gliomas."3.85Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors. ( Bravo, JJ; Davis, SC; Kanick, SC; Olson, JD; Paulsen, KD; Roberts, DW, 2017)
"5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker."3.855-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017)
"Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival."3.81Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015)
"We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells."3.80[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014)
"(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection."3.79Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013)
"Among glioma treatment strategies, 5-aminolevulinic acid (5-ALA)-based fluorescence-guided resection (FGR) and photodynamic therapy (PDT) have been used as effective novel approaches against malignant glioma."3.79Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S, 2013)
"These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas."3.78¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012)
"5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours."3.78Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012)
"In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas."3.78Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012)
" Experiments with protoporphyrin IX in a glioma rodent model demonstrate in vivo quantitative and spectrally-resolved fluorescence imaging of infiltrating tumor margins for the first time."3.78Quantitative, spectrally-resolved intraoperative fluorescence imaging. ( Jacobs, VL; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012)
"To overcome these issues, we assessed the expression of ferrochelatase (FECH) gene, which encodes a key enzyme that catalyses the conversion of protoporphyrin IX (PpIX) to heme, in glioma surgical specimens and manipulated FECH in human glioma cell lines."3.77Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy. ( Endo, Y; Furuyama, N; Hamada, JI; Hayashi, Y; Nakada, M; Nambu, E; Pyko, IV; Teng, L; Zhao, SG, 2011)
"The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated."3.74Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007)
"Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection using 5-aminolevulinic acid labeling is one of the most valuable tools available to determine the extent of glioma infiltration, but requires repeated spectroscopic evaluation of the tissue."3.74Auditory alert system for fluorescence-guided resection of gliomas. ( Fujii, K; Miyajima, Y; Oka, H; Shimizu, S; Suzuki, S; Utsuki, S, 2008)
"Malignant gliomas accumulate fluorescing protoporphyrin IX intracellularly after exposure to 5-aminolevulinic acid, a metabolic precursor of haem."3.70Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. ( Ehrhardt, A; Leonhard, M; Möller, G; Reulen, HJ; Stepp, H; Stummer, W, 1998)
"5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and chlorophyll."2.825-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges. ( Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H, 2022)
"Malignant gliomas are locally invasive tumors that offer a poor prognosis."2.53Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016)
"Gliomas are infiltrative brain tumors with a margin difficult to identify."1.56Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy. ( Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D, 2020)
"Malignant gliomas are rapidly progressive brain tumors with high mortality."1.51Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma. ( Ayinon, C; Balaj, L; Carter, BS; Charest, A; Delcuze, B; Ghiran, I; Hochberg, FH; Jones, PS; Lansbury, E; Mordecai, S; Small, JL; Tigges, J; Yekula, A, 2019)
"Malignant gliomas are highly invasive, difficult to treat, and account for 2% of cancer deaths worldwide."1.46ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. ( Chen, Y; Eubanks, JH; Fisher, CJ; Foltz, W; Lilge, L; Niu, C; Sidorova-Darmos, E, 2017)
"This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy."1.40Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014)
"Complete removal of malignant gliomas is important for the prognosis in neurosurgery treatment."1.39Automatic laser scanning ablation system for high-precision treatment of brain tumors. ( Ando, T; Fujiwara, K; Iseki, H; Kobayashi, E; Liao, H; Maruyama, T; Muragaki, Y; Sakuma, I, 2013)
"5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor."1.32Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003)
"We compared resection completeness and residual tumor, determined by histopathology, after white light resection (WLR) using an operating microscope versus additional fluorescence guided resection (FGR)."1.32Increased brain tumor resection using fluorescence image guidance in a preclinical model. ( Bilbao, JM; Bogaards, A; Collens, SP; Giles, A; Lilge, LD; Lin, A; Muller, PJ; Varma, A; Wilson, BC; Yang, VX, 2004)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (2.38)18.2507
2000's15 (17.86)29.6817
2010's54 (64.29)24.3611
2020's13 (15.48)2.80

Authors

AuthorsStudies
Black, D2
Kaneko, S6
Walke, A1
König, S1
Stummer, W14
Suero Molina, E7
Mansi, M1
Howley, R1
Chandratre, S1
Chen, B1
Harada, Y1
Murayama, Y1
Takamatsu, T1
Otsuji, E1
Tanaka, H1
Lehtonen, SJR1
Vrzakova, H1
Paterno, JJ1
Puustinen, S1
Bednarik, R1
Hauta-Kasari, M1
Haneishi, H1
Immonen, A1
Jääskeläinen, JE1
Kämäräinen, OP1
Elomaa, AP1
Mischkulnig, M1
Traxler, D1
Wadiura, LI1
Lang, A1
Millesi, M1
Kiesel, B2
Widhalm, G2
Schwake, M1
Müther, M1
Schipmann, S2
Köchling, M1
Brentrup, A1
Jones, PS1
Yekula, A1
Lansbury, E1
Small, JL1
Ayinon, C1
Mordecai, S1
Hochberg, FH1
Tigges, J1
Delcuze, B1
Charest, A1
Ghiran, I1
Balaj, L1
Carter, BS1
Bilmin, K1
Kujawska, T1
Grieb, P1
Leclerc, P1
Ray, C1
Mahieu-Williame, L1
Alston, L1
Frindel, C1
Brevet, PF1
Meyronet, D1
Guyotat, J1
Montcel, B1
Rousseau, D1
Stögbauer, L1
Jeibmann, A1
Warneke, N2
Yamamoto, J5
Kitagawa, T5
Miyaoka, R1
Suzuki, K1
Takamatsu, S1
Saito, T2
Nakano, Y5
Higuchi, T2
Yamaguchi, F3
Asakura, T2
Yoshida, D1
Oishi, Y1
Morita, A2
Bunk, EC1
Wagner, A1
Senner, V1
Brokinkel, B3
Belykh, E3
Jubran, JH1
George, LL1
Bardonova, L1
Healey, DR1
Georges, JF1
Quarles, CC1
Eschbacher, JM1
Mehta, S1
Scheck, AC2
Nakaji, P3
Preul, MC3
Sporns, P1
Shono, K1
Mizobuchi, Y1
Yamaguchi, I1
Nakajima, K1
Fujiwara, Y1
Fujihara, T1
Kitazato, K1
Matsuzaki, K1
Uto, Y1
Sampetrean, O1
Saya, H1
Takagi, Y1
Wölfer, J2
Ewelt, C3
Ehrhardt, A2
Wei, L1
Chen, Y2
Yin, C1
Borwege, S1
Sanai, N1
Liu, JTC1
Cozzens, JW1
Lokaitis, BC1
Moore, BE1
Amin, DV1
Espinosa, JA1
MacGregor, M1
Michael, AP1
Jones, BA1
Fisher, CJ1
Niu, C2
Foltz, W1
Sidorova-Darmos, E1
Eubanks, JH1
Lilge, L2
Roberts, DW13
Olson, JD2
Evans, LT2
Kolste, KK1
Kanick, SC2
Fan, X3
Bravo, JJ2
Wilson, BC12
Leblond, F8
Marois, M1
Paulsen, KD12
Davis, SC2
Matsuda, F1
Ikeda, N1
Kajimoto, Y4
Nonoguchi, N2
Takeuchi, K1
Fukumura, M1
Kawabata, S2
Furuse, M1
Sugano, T1
Sato, T1
Saito, K1
Kuroiwa, T4
Miller, EJ2
Hu, D1
Martirosyan, NL1
Woolf, EC1
Byvaltsev, VA1
Nelson, LY2
Seibel, EJ2
Jaber, M1
Thomas, C1
Hasselblatt, M1
Grauer, O1
Patel, AA1
Bozkurt, B1
Yağmurlu, K1
Robinson, TR1
Spetzler, RF1
Lawton, MT1
Wirth, D1
Sibai, M1
Olson, J1
Paulsen, K1
Kamp, MA1
Knipps, J1
Neumann, LM1
Mijderwijk, HJ1
Dibué-Adjei, M1
Steiger, HJ1
Slotty, PJ1
Rapp, M1
Cornelius, JF1
Sabel, M1
Masubuchi, T1
Fujishiro, T1
Miyatake, S3
Valdes, PA9
Jacobs, VL2
Wang, C2
Chen, X3
Wu, J1
Liu, H3
Ji, Z1
Shi, H1
Gao, C1
Han, D1
Wang, L2
Liu, Y2
Yang, G3
Fu, C2
Li, H1
Zhang, D2
Liu, Z2
Li, X2
Yin, F2
Zhao, S2
Teng, L3
Zhang, Y1
Guan, H1
Zhao, B1
Woehrer, A1
Traub-Weidinger, T1
Preusser, M1
Marosi, C1
Prayer, D1
Hainfellner, JA1
Knosp, E1
Wolfsberger, S1
Petterssen, M1
Eljamel, S2
Kitai, R1
Takeuchi, H1
Miyoshi, N2
Andriana, B1
Neishi, H1
Hashimoto, N2
Kikuta, K1
Tanaka, T4
Akiba, D3
Ueta, K3
Nishizawa, S4
Ogura, S2
Shimajiri, S1
Haj-Hosseini, N1
Richter, JC1
Hallbeck, M1
Wårdell, K1
Jacobs, V1
Harris, BT6
Niu, CJ1
Fisher, C1
Scheffler, K1
Wan, R1
Maleki, H1
Sun, Y1
A Simmons, C1
Birngruber, R1
Ju, D1
Zhan, G1
Orimo, H1
Hu, S1
Ma, R1
Watts, C1
Pustogarov, N1
Panteleev, D1
Goryaynov, SA1
Ryabova, AV1
Rybalkina, EY1
Revishchin, A1
Potapov, AA1
Pavlova, G1
Elliott, JT1
Marra, K1
Samkoe, KS1
Feldwisch, J1
Pogue, BW3
Nakae, S1
Murayama, K1
Sasaki, H1
Kumon, M1
Nishiyama, Y1
Ohba, S1
Adachi, K1
Nagahisa, S1
Hayashi, T1
Inamasu, J1
Abe, M1
Hasegawa, M1
Hirose, Y1
Wang, W1
Tabu, K1
Hagiya, Y1
Sugiyama, Y1
Kokubu, Y1
Murota, Y1
Ogura, SI1
Taga, T1
Gibbs-Strauss, SL1
O'Hara, JA1
Srinivasan, S1
Hoopes, PJ1
Hasan, T1
Fontaine, KM1
Hartov, A2
Ji, S2
Lollis, SS1
Tosteson, TD3
Engh, JA1
Ando, T2
Kobayashi, E2
Liao, H2
Maruyama, T3
Muragaki, Y2
Iseki, H2
Kubo, O1
Sakuma, I2
Nakada, M1
Zhao, SG2
Endo, Y1
Furuyama, N1
Nambu, E1
Pyko, IV1
Hayashi, Y1
Hamada, JI1
Kim, A4
Erkmen, K1
Simmons, NE1
Nishikawa, R1
Brantsch, M1
Moses, ZB2
Arita, H1
Kinoshita, M1
Kagawa, N1
Fujimoto, Y1
Kishima, H1
Yoshimine, T1
Conde, OM1
Takahashi, M1
Hefti, M2
Albert, I1
Luginbuehl, V1
Konecky, SD1
Owen, CM1
Rice, T1
Kolste, K1
Tromberg, BJ1
Chen, XF1
Wang, LG1
Han, DY1
Yang, MC1
Wang, DY1
Shi, C1
Liu, YH1
Zheng, BJ1
Shi, CB1
Gao, X1
Rainov, NG1
Fujiwara, K1
Belden, CJ1
Colditz, MJ2
Jeffree, RL2
Leyen, Kv1
Reulen, HJ3
Novotny, A2
Stepp, H4
Tonn, JC1
Wu, SM1
Ren, QG1
Zhou, MO1
Peng, Q2
Chen, JY1
Bogaards, A1
Varma, A1
Collens, SP1
Lin, A1
Giles, A1
Yang, VX1
Bilbao, JM1
Lilge, LD1
Muller, PJ1
Hirschberg, H1
Sørensen, DR1
Angell-Petersen, E1
Tromberg, B1
Sun, CH1
Spetalen, S1
Madsen, S1
Teramoto, A1
Takahashi, H1
Inoue, H1
Shibata, MA1
Ogawa, N1
Otsuki, Y1
Beck, TJ2
Burkanas, M1
Bagdonas, S1
Krivickiene, Z1
Beyer, W2
Sroka, R1
Baumgartner, R2
Rotomskis, R1
Kreth, FW2
Mehrkens, JH1
Obermeier, A1
Beck, T1
Pongratz, T1
Meinel, T1
Tonn, JCh1
Utsuki, S1
Oka, H1
Miyajima, Y1
Shimizu, S1
Suzuki, S1
Fujii, K1
von Campe, G1
Moschopulos, M1
Siegner, A1
Looser, H1
Landolt, H1
Möller, G1
Leonhard, M1
Stocker, S1
Heimann, A1
Sauer, O1
Kempski, O1
Plesnila, N1
Wietzorrek, J1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377]90 participants (Anticipated)Observational2023-06-01Not yet recruiting
Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488]Phase 1540 participants (Anticipated)Interventional2014-07-31Active, not recruiting
Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas[NCT04937244]Phase 410 participants (Anticipated)Interventional2021-05-13Recruiting
Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker: Correlation With Preoperative MR, ALA-induced PpIX Fluorescence, and Histopathology[NCT02691923]Phase 230 participants (Anticipated)Interventional2016-03-31Recruiting
Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737]43 participants (Actual)Interventional2019-11-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for protoporphyrin ix and Glioma

ArticleYear
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
    International journal of molecular sciences, 2022, Jun-09, Volume: 23, Issue:12

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photoche

2022
Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells.
    Cells, 2019, 11-13, Volume: 8, Issue:11

    Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Disease Models, Animal; Glioma; Humans; Light; Pro

2019
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
    Journal of UOEH, 2020, Volume: 42, Issue:1

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Mitochondria; Photosensitizing A

2020
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
    Acta neurochirurgica, 2016, Volume: 158, Issue:10

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neurons; Neurosurgical Procedure

2016
[Intraoperative photo-dynamic diagnosis of brain tumors].
    Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:7

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat

2009
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:11

    Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Fluorescence; Glioma; Humans; Magnetic

2012
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:12

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Ph

2012
[Intraoperative photodynamic diagnosis using 5-ALA for glioma surgery].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 9

    Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Monitoring, Intraoperative; Neoplasm, Residual

2005
Repetitive photodynamic therapy of malignant brain tumors.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Light; Photochemotherapy; Photosensit

2006
[Intraoperative photodynamic diagnosis of human glioma using ALA induced protoporphyrin IX].
    No shinkei geka. Neurological surgery, 2001, Volume: 29, Issue:11

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Male; Mice; Middle Aged; Monitoring,

2001

Trials

5 trials available for protoporphyrin ix and Glioma

ArticleYear
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma.
    Neurosurgery, 2017, Jul-01, Volume: 81, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Craniotomy; Dose-Re

2017
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
    Journal of neurosurgery, 2018, Volume: 128, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye

2018
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
    Journal of neurosurgery, 2011, Volume: 115, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl

2011
Fluorescence-guided resections of malignant gliomas--an overview.
    Acta neurochirurgica. Supplement, 2003, Volume: 88

    Topics: Aminolevulinic Acid; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Fluorescenc

2003
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2007, Volume: 26, Issue:2

    Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Fluoresc

2007

Other Studies

69 other studies available for protoporphyrin ix and Glioma

ArticleYear
Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery.
    Scientific reports, 2021, 10-08, Volume: 11, Issue:1

    Topics: Biomarkers, Tumor; Blood-Brain Barrier; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neuroglia

2021
Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines.
    Biochemical pharmacology, 2022, Volume: 200

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferr

2022
Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds.
    Cancer treatment and research communications, 2022, Volume: 32

    Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Hyperspectral Imaging; Photosensitizing Agents

2022
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.
    Journal of biomedical optics, 2023, Volume: 28, Issue:10

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Microscopy, Fluorescence; Photos

2023
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.
    Acta neurochirurgica, 2019, Volume: 161, Issue:10

    Topics: Adolescent; Aminolevulinic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Fluorescen

2019
Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.
    EBioMedicine, 2019, Volume: 48

    Topics: Adult; Aged; Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal;

2019
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
    Scientific reports, 2020, 01-29, Volume: 10, Issue:1

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Compute

2020
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
    Acta neurochirurgica, 2020, Volume: 162, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fl

2020
Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2021, Jan-08, Volume: 87, Issue:6

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Fluo

2021
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
    Journal of neuro-oncology, 2021, Volume: 152, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op

2021
Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery.
    Molecular imaging and biology, 2021, Volume: 23, Issue:4

    Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Cell

2021
Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma.
    Journal of neurosurgery, 2022, Jan-01, Volume: 136, Issue:1

    Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Chromosome Deletion; Female; Fluorescence; Glioma; Huma

2022
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
    Scientific reports, 2021, 07-23, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tu

2021
Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note.
    Journal of neurosurgery, 2018, Volume: 128, Issue:2

    Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescein; Fluorescence; Fluorescent Dyes; Glioma; H

2018
Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.
    Journal of biomedical optics, 2017, 04-01, Volume: 22, Issue:4

    Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Disease-Free Survival; Glioma;

2017
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor

2017
Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.
    Scientific reports, 2017, 08-25, Volume: 7, Issue:1

    Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Electronic Data Processing; Glioma; Humans; Neuros

2017
Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 20

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Levulinic Acids; Neurosurgical Procedures; O

2017
Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.
    World neurosurgery, 2018, Volume: 113

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biotransformation; Brain Neoplasms; Cell Line, T

2018
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
    Neurosurgery, 2019, 06-01, Volume: 84, Issue:6

    Topics: Adult; Aminolevulinic Acid; Biomarkers; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma; Human

2019
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
    Scientific reports, 2018, 08-22, Volume: 8, Issue:1

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent D

2018
Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.
    Journal of biomedical optics, 2018, Volume: 24, Issue:7

    Topics: Brain; Brain Neoplasms; Equipment Design; Feasibility Studies; Glioma; Humans; Optical Imaging; Phan

2018
Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas.
    Neurosurgery, 2019, 10-01, Volume: 85, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Kineti

2019
Optimizing 5-ALA Induced Fluorescence Visualization: Comment Regarding Recent Article on Fluorescence-Based Real-Time Kinetics Protoporphyrin-IX Measurements Article in Neurosurgery.
    World neurosurgery, 2019, Volume: 128

    Topics: Aminolevulinic Acid; Fluorescence; Glioma; Humans; Kinetics; Neurosurgery; Photosensitizing Agents;

2019
Is the Intensity of 5-Aminolevulinic Acid-Derived Fluorescence Related to the Light Source?
    World neurosurgery, 2019, Volume: 131

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Light; Neurosurgical Procedures;

2019
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
    Photomedicine and laser surgery, 2013, Volume: 31, Issue:9

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R

2013
System and methods for wide-field quantitative fluorescence imaging during neurosurgery.
    Optics letters, 2013, Aug-01, Volume: 38, Issue:15

    Topics: Animals; Brain; Glioma; Neurosurgery; Protoporphyrins; Rats; Spectrometry, Fluorescence; Surgery, Co

2013
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
    Journal of photochemistry and photobiology. B, Biology, 2013, Oct-05, Volume: 127

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Surviv

2013
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
    Acta oncologica (Stockholm, Sweden), 2014, Volume: 53, Issue:3

    Topics: Aminolevulinic Acid; Astrocytes; Brain Neoplasms; Calcitriol; Cell Line, Tumor; Cell Survival; Enzym

2014
5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Female; Fluorescence; Glioma;

2013
Protoporphyrin-IX fluorescence guided surgical resection in high-grade gliomas: The potential impact of human colour perception.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:3

    Topics: Brain Neoplasms; Color Perception; Female; Fluorescent Dyes; Glioma; Humans; Male; Microscopy, Fluor

2014
[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases].
    No shinkei geka. Neurological surgery, 2014, Volume: 42, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Count; Cell Line, Tumor; Female; Gl

2014
5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.
    Oncology reports, 2015, Volume: 33, Issue:2

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cytoplasm; Glioma; Humans; In Vitro

2015
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
    Molecular medicine reports, 2015, Volume: 11, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity,

2015
Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:2

    Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Fluorescence;

2015
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.
    Journal of neurosurgery, 2015, Volume: 123, Issue:3

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Fluorescence; Glioma; Humans;

2015
Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells.
    Journal of biomedical optics, 2015, Volume: 20, Issue:9

    Topics: Acrylic Resins; Cell Count; Cell Line, Tumor; Cell Proliferation; Cellular Microenvironment; Elastic

2015
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:8

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Combined M

2016
Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.
    Molecular neurobiology, 2017, Volume: 54, Issue:7

    Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Coproporphyrinogen Oxidase; Fluorescence; Gl

2017
Simultaneous
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, May-01, Volume: 23, Issue:9

    Topics: Animals; Cell Line, Tumor; ErbB Receptors; Fluorescent Dyes; Gene Expression Regulation, Neoplastic;

2017
Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
    Journal of neuro-oncology, 2017, Volume: 131, Issue:2

    Topics: Adult; Aminolevulinic Acid; Female; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spe

2017
5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.
    International journal of molecular medicine, 2017, Volume: 39, Issue:2

    Topics: Aminolevulinic Acid; Apoptosis; Biological Transport; Brain Neoplasms; Cell Death; Cell Line, Tumor;

2017
Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.
    Scientific reports, 2017, 02-07, Volume: 7

    Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biotransforma

2017
Diagnostic detection of diffuse glioma tumors in vive with molecular fluorescent probe-based transmission spectroscopy.
    Medical physics, 2009, Volume: 36, Issue:3

    Topics: Animals; Biophysical Phenomena; Brain Neoplasms; Cell Line, Tumor; ErbB Receptors; Fluorescent Dyes;

2009
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
    Journal of neurosurgery, 2011, Volume: 114, Issue:3

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Data Interpretation, Statisti

2011
Improving intraoperative visualization of anaplastic foci within gliomas.
    Neurosurgery, 2010, Volume: 67, Issue:2

    Topics: Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Fluorescence; Glioma; Humans; Protoporphyri

2010
Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification.
    Brain tumor pathology, 2011, Volume: 28, Issue:1

    Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents; Protoporphyrins; Spec

2011
Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.
    British journal of cancer, 2011, Mar-01, Volume: 104, Issue:5

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Ferrochelatase; Fluorescence; Gene Silencing; Glioma; Humans;

2011
Fluorescence illuminates the way ...
    Neuro-oncology, 2011, Volume: 13, Issue:8

    Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Male; Monitoring, Intraope

2011
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
    Neuro-oncology, 2011, Volume: 13, Issue:8

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Female; Fluoresce

2011
¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.
    Cancer, 2012, Mar-15, Volume: 118, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Carbon Radioisotopes; Cell Count; Cell Proliferat

2012
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery.
    Journal of biomedical optics, 2011, Volume: 16, Issue:11

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Diagnostic Imaging; Glioma; Humans; Models, Biological; Prot

2011
Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro.
    Oncology reports, 2012, Volume: 27, Issue:6

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Protoporphyrins; Radiation-Sensitizing Agent

2012
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
    Journal of neuro-oncology, 2012, Volume: 108, Issue:3

    Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Memb

2012
Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models.
    Journal of biomedical optics, 2012, Volume: 17, Issue:5

    Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Contrast Media; Glioma; Mice; Mice, Nude; Microscopy, Fl

2012
Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.
    Annals of surgical oncology, 2013, Volume: 20, Issue:13

    Topics: Aminolevulinic Acid; Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Brain; Brain N

2013
Automatic laser scanning ablation system for high-precision treatment of brain tumors.
    Lasers in medical science, 2013, Volume: 28, Issue:3

    Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Equipment Design; Glioma; Humans; Laser Therap

2013
Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.
    Journal of neuropathology and experimental neurology, 2012, Volume: 71, Issue:9

    Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Craniotomy; Creatinine; Female; Gadoliniu

2012
Quantitative, spectrally-resolved intraoperative fluorescence imaging.
    Scientific reports, 2012, Volume: 2

    Topics: Animals; Brain Neoplasms; Fluorescence; Fluorescent Dyes; Glioma; Humans; Intraoperative Period; Opt

2012
Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester.
    Cancer letters, 2003, Oct-28, Volume: 200, Issue:2

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line; Cerebellum; Glioma; Humans; Neuroblastoma;

2003
Increased brain tumor resection using fluorescence image guidance in a preclinical model.
    Lasers in surgery and medicine, 2004, Volume: 35, Issue:3

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Microscopy; Models, Animal; Neoplasm, Residua

2004
[5-ALA fluorescence guided tumor resection].
    No to shinkei = Brain and nerve, 2006, Volume: 58, Issue:12

    Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Middle Aged; Mitochondri

2006
Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.
    Journal of neuro-oncology, 2007, Volume: 83, Issue:3

    Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes

2007
Two-photon photodynamic therapy of C6 cells by means of 5-aminolevulinic acid induced protoporphyrin IX.
    Journal of photochemistry and photobiology. B, Biology, 2007, Jun-26, Volume: 87, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship

2007
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX.
    Lasers in surgery and medicine, 2007, Volume: 39, Issue:5

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Feasibility Studies; Glioma; Humans; Magnetic Res

2007
Auditory alert system for fluorescence-guided resection of gliomas.
    Neurologia medico-chirurgica, 2008, Volume: 48, Issue:2

    Topics: Acoustic Stimulation; Brain Neoplasms; Diagnosis, Computer-Assisted; Glioma; Humans; Neoplasm Invasi

2008
5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion.
    Swiss medical weekly, 2008, Mar-22, Volume: 138, Issue:11-12

    Topics: Aminolevulinic Acid; Biopsy; Fluorescence; Glioma; Humans; Prognosis; Protoporphyrins; Sensitivity a

2008
Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue.
    Acta neurochirurgica, 1998, Volume: 140, Issue:10

    Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Mi

1998
In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 1998, Volume: 45, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioma; Humans; Male; Photosensitizing Agents;

1998