protoporphyrin ix has been researched along with Glioma in 84 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented." | 9.24 | A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 9.05 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| "5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection." | 8.12 | Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022) |
| "5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas." | 8.12 | Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022) |
| "5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection." | 8.12 | Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022) |
| "5-Aminolevulinic Acid (5-ALA) photodiagnosis (PD) is an effective method to detect residual tumors during glioma surgery." | 8.02 | Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells. ( Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D, 2021) |
| "Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration." | 7.91 | Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019) |
| "Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors." | 7.91 | Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019) |
| "Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas." | 7.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas." | 7.88 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker." | 7.85 | 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 7.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival." | 7.81 | Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015) |
| "We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells." | 7.80 | [Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014) |
| "Among glioma treatment strategies, 5-aminolevulinic acid (5-ALA)-based fluorescence-guided resection (FGR) and photodynamic therapy (PDT) have been used as effective novel approaches against malignant glioma." | 7.79 | Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S, 2013) |
| "These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas." | 7.78 | ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012) |
| "5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours." | 7.78 | Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012) |
| "In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas." | 7.78 | Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| "The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated." | 7.74 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "Malignant gliomas are locally invasive tumors that offer a poor prognosis." | 6.53 | Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016) |
| "This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy." | 5.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor." | 5.32 | Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003) |
| "OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination." | 5.27 | Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018) |
| "The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented." | 5.24 | A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017) |
| " Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)." | 5.15 | Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011) |
| "Oral application of 20 mg/kg body weight of 5-aminolevulinic acid (ALA) leads to a highly specific accumulation of fluorescent Protoporphyrin IX (PPIX) in malignant glioma tissue." | 5.12 | ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. ( Beck, T; Kreth, FW; Meinel, T; Pongratz, T; Stepp, H; Stummer, W; Tonn, JCh, 2007) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 5.05 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| "The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade." | 4.88 | Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. ( Colditz, MJ; Jeffree, RL; Leyen, Kv, 2012) |
| "Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas." | 4.85 | [Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009) |
| "5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas." | 4.12 | Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022) |
| "5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection." | 4.12 | Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022) |
| "5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection." | 4.12 | Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022) |
| "This study evaluated the use of molecular imaging of fluorescent glucose analog 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) as a discriminatory marker for intraoperative tumor border identification in a murine glioma model." | 4.02 | Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. ( Bardonova, L; Belykh, E; Eschbacher, JM; George, LL; Georges, JF; Healey, DR; Jubran, JH; Mehta, S; Nakaji, P; Preul, MC; Quarles, CC; Scheck, AC, 2021) |
| "Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse." | 4.02 | 5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021) |
| "5-Aminolevulinic Acid (5-ALA) photodiagnosis (PD) is an effective method to detect residual tumors during glioma surgery." | 4.02 | Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells. ( Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D, 2021) |
| "Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration." | 3.91 | Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019) |
| "Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors." | 3.91 | Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019) |
| "5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients' outcome." | 3.91 | Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors. ( Brentrup, A; Kaneko, S; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W; Suero Molina, E, 2019) |
| "Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas." | 3.88 | Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching. ( Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K, 2018) |
| "Mapping the optical absorption and scattering properties of tissues using spatial frequency-domain imaging (SFDI) enhances quantitative fluorescence imaging of protoporphyrin IX (PpIX) in gliomas in the preclinical setting." | 3.88 | Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection. ( Olson, J; Paulsen, K; Roberts, DW; Sibai, M; Wilson, BC; Wirth, D, 2018) |
| "Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas." | 3.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas." | 3.88 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "Fluorescence image guided surgery (FIGS) with 5-aminolevulinic acid for malignant gliomas improves surgical outcome." | 3.85 | Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid. ( Fukumura, M; Furuse, M; Ikeda, N; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Matsuda, F; Nonoguchi, N; Saito, K; Sato, T; Sugano, T; Takeuchi, K, 2017) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 3.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "Fluorescence guided surgery (FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual contrast between normal and malignant tissue during resection of high grade gliomas." | 3.85 | Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors. ( Bravo, JJ; Davis, SC; Kanick, SC; Olson, JD; Paulsen, KD; Roberts, DW, 2017) |
| "5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker." | 3.85 | 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017) |
| "Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival." | 3.81 | Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015) |
| "We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells." | 3.80 | [Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014) |
| "(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection." | 3.79 | Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013) |
| "Among glioma treatment strategies, 5-aminolevulinic acid (5-ALA)-based fluorescence-guided resection (FGR) and photodynamic therapy (PDT) have been used as effective novel approaches against malignant glioma." | 3.79 | Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S, 2013) |
| "These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas." | 3.78 | ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012) |
| "5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours." | 3.78 | Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012) |
| "In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas." | 3.78 | Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| " Experiments with protoporphyrin IX in a glioma rodent model demonstrate in vivo quantitative and spectrally-resolved fluorescence imaging of infiltrating tumor margins for the first time." | 3.78 | Quantitative, spectrally-resolved intraoperative fluorescence imaging. ( Jacobs, VL; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| "To overcome these issues, we assessed the expression of ferrochelatase (FECH) gene, which encodes a key enzyme that catalyses the conversion of protoporphyrin IX (PpIX) to heme, in glioma surgical specimens and manipulated FECH in human glioma cell lines." | 3.77 | Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy. ( Endo, Y; Furuyama, N; Hamada, JI; Hayashi, Y; Nakada, M; Nambu, E; Pyko, IV; Teng, L; Zhao, SG, 2011) |
| "The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated." | 3.74 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection using 5-aminolevulinic acid labeling is one of the most valuable tools available to determine the extent of glioma infiltration, but requires repeated spectroscopic evaluation of the tissue." | 3.74 | Auditory alert system for fluorescence-guided resection of gliomas. ( Fujii, K; Miyajima, Y; Oka, H; Shimizu, S; Suzuki, S; Utsuki, S, 2008) |
| "Malignant gliomas accumulate fluorescing protoporphyrin IX intracellularly after exposure to 5-aminolevulinic acid, a metabolic precursor of haem." | 3.70 | Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. ( Ehrhardt, A; Leonhard, M; Möller, G; Reulen, HJ; Stepp, H; Stummer, W, 1998) |
| "5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and chlorophyll." | 2.82 | 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges. ( Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H, 2022) |
| "Malignant gliomas are locally invasive tumors that offer a poor prognosis." | 2.53 | Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016) |
| "Gliomas are infiltrative brain tumors with a margin difficult to identify." | 1.56 | Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy. ( Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D, 2020) |
| "Malignant gliomas are rapidly progressive brain tumors with high mortality." | 1.51 | Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma. ( Ayinon, C; Balaj, L; Carter, BS; Charest, A; Delcuze, B; Ghiran, I; Hochberg, FH; Jones, PS; Lansbury, E; Mordecai, S; Small, JL; Tigges, J; Yekula, A, 2019) |
| "Malignant gliomas are highly invasive, difficult to treat, and account for 2% of cancer deaths worldwide." | 1.46 | ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. ( Chen, Y; Eubanks, JH; Fisher, CJ; Foltz, W; Lilge, L; Niu, C; Sidorova-Darmos, E, 2017) |
| "This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy." | 1.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "Complete removal of malignant gliomas is important for the prognosis in neurosurgery treatment." | 1.39 | Automatic laser scanning ablation system for high-precision treatment of brain tumors. ( Ando, T; Fujiwara, K; Iseki, H; Kobayashi, E; Liao, H; Maruyama, T; Muragaki, Y; Sakuma, I, 2013) |
| "5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor." | 1.32 | Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003) |
| "We compared resection completeness and residual tumor, determined by histopathology, after white light resection (WLR) using an operating microscope versus additional fluorescence guided resection (FGR)." | 1.32 | Increased brain tumor resection using fluorescence image guidance in a preclinical model. ( Bilbao, JM; Bogaards, A; Collens, SP; Giles, A; Lilge, LD; Lin, A; Muller, PJ; Varma, A; Wilson, BC; Yang, VX, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.38) | 18.2507 |
| 2000's | 15 (17.86) | 29.6817 |
| 2010's | 54 (64.29) | 24.3611 |
| 2020's | 13 (15.48) | 2.80 |
| Authors | Studies |
|---|---|
| Black, D | 2 |
| Kaneko, S | 6 |
| Walke, A | 1 |
| König, S | 1 |
| Stummer, W | 14 |
| Suero Molina, E | 7 |
| Mansi, M | 1 |
| Howley, R | 1 |
| Chandratre, S | 1 |
| Chen, B | 1 |
| Harada, Y | 1 |
| Murayama, Y | 1 |
| Takamatsu, T | 1 |
| Otsuji, E | 1 |
| Tanaka, H | 1 |
| Lehtonen, SJR | 1 |
| Vrzakova, H | 1 |
| Paterno, JJ | 1 |
| Puustinen, S | 1 |
| Bednarik, R | 1 |
| Hauta-Kasari, M | 1 |
| Haneishi, H | 1 |
| Immonen, A | 1 |
| Jääskeläinen, JE | 1 |
| Kämäräinen, OP | 1 |
| Elomaa, AP | 1 |
| Mischkulnig, M | 1 |
| Traxler, D | 1 |
| Wadiura, LI | 1 |
| Lang, A | 1 |
| Millesi, M | 1 |
| Kiesel, B | 2 |
| Widhalm, G | 2 |
| Schwake, M | 1 |
| Müther, M | 1 |
| Schipmann, S | 2 |
| Köchling, M | 1 |
| Brentrup, A | 1 |
| Jones, PS | 1 |
| Yekula, A | 1 |
| Lansbury, E | 1 |
| Small, JL | 1 |
| Ayinon, C | 1 |
| Mordecai, S | 1 |
| Hochberg, FH | 1 |
| Tigges, J | 1 |
| Delcuze, B | 1 |
| Charest, A | 1 |
| Ghiran, I | 1 |
| Balaj, L | 1 |
| Carter, BS | 1 |
| Bilmin, K | 1 |
| Kujawska, T | 1 |
| Grieb, P | 1 |
| Leclerc, P | 1 |
| Ray, C | 1 |
| Mahieu-Williame, L | 1 |
| Alston, L | 1 |
| Frindel, C | 1 |
| Brevet, PF | 1 |
| Meyronet, D | 1 |
| Guyotat, J | 1 |
| Montcel, B | 1 |
| Rousseau, D | 1 |
| Stögbauer, L | 1 |
| Jeibmann, A | 1 |
| Warneke, N | 2 |
| Yamamoto, J | 5 |
| Kitagawa, T | 5 |
| Miyaoka, R | 1 |
| Suzuki, K | 1 |
| Takamatsu, S | 1 |
| Saito, T | 2 |
| Nakano, Y | 5 |
| Higuchi, T | 2 |
| Yamaguchi, F | 3 |
| Asakura, T | 2 |
| Yoshida, D | 1 |
| Oishi, Y | 1 |
| Morita, A | 2 |
| Bunk, EC | 1 |
| Wagner, A | 1 |
| Senner, V | 1 |
| Brokinkel, B | 3 |
| Belykh, E | 3 |
| Jubran, JH | 1 |
| George, LL | 1 |
| Bardonova, L | 1 |
| Healey, DR | 1 |
| Georges, JF | 1 |
| Quarles, CC | 1 |
| Eschbacher, JM | 1 |
| Mehta, S | 1 |
| Scheck, AC | 2 |
| Nakaji, P | 3 |
| Preul, MC | 3 |
| Sporns, P | 1 |
| Shono, K | 1 |
| Mizobuchi, Y | 1 |
| Yamaguchi, I | 1 |
| Nakajima, K | 1 |
| Fujiwara, Y | 1 |
| Fujihara, T | 1 |
| Kitazato, K | 1 |
| Matsuzaki, K | 1 |
| Uto, Y | 1 |
| Sampetrean, O | 1 |
| Saya, H | 1 |
| Takagi, Y | 1 |
| Wölfer, J | 2 |
| Ewelt, C | 3 |
| Ehrhardt, A | 2 |
| Wei, L | 1 |
| Chen, Y | 2 |
| Yin, C | 1 |
| Borwege, S | 1 |
| Sanai, N | 1 |
| Liu, JTC | 1 |
| Cozzens, JW | 1 |
| Lokaitis, BC | 1 |
| Moore, BE | 1 |
| Amin, DV | 1 |
| Espinosa, JA | 1 |
| MacGregor, M | 1 |
| Michael, AP | 1 |
| Jones, BA | 1 |
| Fisher, CJ | 1 |
| Niu, C | 2 |
| Foltz, W | 1 |
| Sidorova-Darmos, E | 1 |
| Eubanks, JH | 1 |
| Lilge, L | 2 |
| Roberts, DW | 13 |
| Olson, JD | 2 |
| Evans, LT | 2 |
| Kolste, KK | 1 |
| Kanick, SC | 2 |
| Fan, X | 3 |
| Bravo, JJ | 2 |
| Wilson, BC | 12 |
| Leblond, F | 8 |
| Marois, M | 1 |
| Paulsen, KD | 12 |
| Davis, SC | 2 |
| Matsuda, F | 1 |
| Ikeda, N | 1 |
| Kajimoto, Y | 4 |
| Nonoguchi, N | 2 |
| Takeuchi, K | 1 |
| Fukumura, M | 1 |
| Kawabata, S | 2 |
| Furuse, M | 1 |
| Sugano, T | 1 |
| Sato, T | 1 |
| Saito, K | 1 |
| Kuroiwa, T | 4 |
| Miller, EJ | 2 |
| Hu, D | 1 |
| Martirosyan, NL | 1 |
| Woolf, EC | 1 |
| Byvaltsev, VA | 1 |
| Nelson, LY | 2 |
| Seibel, EJ | 2 |
| Jaber, M | 1 |
| Thomas, C | 1 |
| Hasselblatt, M | 1 |
| Grauer, O | 1 |
| Patel, AA | 1 |
| Bozkurt, B | 1 |
| Yağmurlu, K | 1 |
| Robinson, TR | 1 |
| Spetzler, RF | 1 |
| Lawton, MT | 1 |
| Wirth, D | 1 |
| Sibai, M | 1 |
| Olson, J | 1 |
| Paulsen, K | 1 |
| Kamp, MA | 1 |
| Knipps, J | 1 |
| Neumann, LM | 1 |
| Mijderwijk, HJ | 1 |
| Dibué-Adjei, M | 1 |
| Steiger, HJ | 1 |
| Slotty, PJ | 1 |
| Rapp, M | 1 |
| Cornelius, JF | 1 |
| Sabel, M | 1 |
| Masubuchi, T | 1 |
| Fujishiro, T | 1 |
| Miyatake, S | 3 |
| Valdes, PA | 9 |
| Jacobs, VL | 2 |
| Wang, C | 2 |
| Chen, X | 3 |
| Wu, J | 1 |
| Liu, H | 3 |
| Ji, Z | 1 |
| Shi, H | 1 |
| Gao, C | 1 |
| Han, D | 1 |
| Wang, L | 2 |
| Liu, Y | 2 |
| Yang, G | 3 |
| Fu, C | 2 |
| Li, H | 1 |
| Zhang, D | 2 |
| Liu, Z | 2 |
| Li, X | 2 |
| Yin, F | 2 |
| Zhao, S | 2 |
| Teng, L | 3 |
| Zhang, Y | 1 |
| Guan, H | 1 |
| Zhao, B | 1 |
| Woehrer, A | 1 |
| Traub-Weidinger, T | 1 |
| Preusser, M | 1 |
| Marosi, C | 1 |
| Prayer, D | 1 |
| Hainfellner, JA | 1 |
| Knosp, E | 1 |
| Wolfsberger, S | 1 |
| Petterssen, M | 1 |
| Eljamel, S | 2 |
| Kitai, R | 1 |
| Takeuchi, H | 1 |
| Miyoshi, N | 2 |
| Andriana, B | 1 |
| Neishi, H | 1 |
| Hashimoto, N | 2 |
| Kikuta, K | 1 |
| Tanaka, T | 4 |
| Akiba, D | 3 |
| Ueta, K | 3 |
| Nishizawa, S | 4 |
| Ogura, S | 2 |
| Shimajiri, S | 1 |
| Haj-Hosseini, N | 1 |
| Richter, JC | 1 |
| Hallbeck, M | 1 |
| Wårdell, K | 1 |
| Jacobs, V | 1 |
| Harris, BT | 6 |
| Niu, CJ | 1 |
| Fisher, C | 1 |
| Scheffler, K | 1 |
| Wan, R | 1 |
| Maleki, H | 1 |
| Sun, Y | 1 |
| A Simmons, C | 1 |
| Birngruber, R | 1 |
| Ju, D | 1 |
| Zhan, G | 1 |
| Orimo, H | 1 |
| Hu, S | 1 |
| Ma, R | 1 |
| Watts, C | 1 |
| Pustogarov, N | 1 |
| Panteleev, D | 1 |
| Goryaynov, SA | 1 |
| Ryabova, AV | 1 |
| Rybalkina, EY | 1 |
| Revishchin, A | 1 |
| Potapov, AA | 1 |
| Pavlova, G | 1 |
| Elliott, JT | 1 |
| Marra, K | 1 |
| Samkoe, KS | 1 |
| Feldwisch, J | 1 |
| Pogue, BW | 3 |
| Nakae, S | 1 |
| Murayama, K | 1 |
| Sasaki, H | 1 |
| Kumon, M | 1 |
| Nishiyama, Y | 1 |
| Ohba, S | 1 |
| Adachi, K | 1 |
| Nagahisa, S | 1 |
| Hayashi, T | 1 |
| Inamasu, J | 1 |
| Abe, M | 1 |
| Hasegawa, M | 1 |
| Hirose, Y | 1 |
| Wang, W | 1 |
| Tabu, K | 1 |
| Hagiya, Y | 1 |
| Sugiyama, Y | 1 |
| Kokubu, Y | 1 |
| Murota, Y | 1 |
| Ogura, SI | 1 |
| Taga, T | 1 |
| Gibbs-Strauss, SL | 1 |
| O'Hara, JA | 1 |
| Srinivasan, S | 1 |
| Hoopes, PJ | 1 |
| Hasan, T | 1 |
| Fontaine, KM | 1 |
| Hartov, A | 2 |
| Ji, S | 2 |
| Lollis, SS | 1 |
| Tosteson, TD | 3 |
| Engh, JA | 1 |
| Ando, T | 2 |
| Kobayashi, E | 2 |
| Liao, H | 2 |
| Maruyama, T | 3 |
| Muragaki, Y | 2 |
| Iseki, H | 2 |
| Kubo, O | 1 |
| Sakuma, I | 2 |
| Nakada, M | 1 |
| Zhao, SG | 2 |
| Endo, Y | 1 |
| Furuyama, N | 1 |
| Nambu, E | 1 |
| Pyko, IV | 1 |
| Hayashi, Y | 1 |
| Hamada, JI | 1 |
| Kim, A | 4 |
| Erkmen, K | 1 |
| Simmons, NE | 1 |
| Nishikawa, R | 1 |
| Brantsch, M | 1 |
| Moses, ZB | 2 |
| Arita, H | 1 |
| Kinoshita, M | 1 |
| Kagawa, N | 1 |
| Fujimoto, Y | 1 |
| Kishima, H | 1 |
| Yoshimine, T | 1 |
| Conde, OM | 1 |
| Takahashi, M | 1 |
| Hefti, M | 2 |
| Albert, I | 1 |
| Luginbuehl, V | 1 |
| Konecky, SD | 1 |
| Owen, CM | 1 |
| Rice, T | 1 |
| Kolste, K | 1 |
| Tromberg, BJ | 1 |
| Chen, XF | 1 |
| Wang, LG | 1 |
| Han, DY | 1 |
| Yang, MC | 1 |
| Wang, DY | 1 |
| Shi, C | 1 |
| Liu, YH | 1 |
| Zheng, BJ | 1 |
| Shi, CB | 1 |
| Gao, X | 1 |
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| Colditz, MJ | 2 |
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| Reulen, HJ | 3 |
| Novotny, A | 2 |
| Stepp, H | 4 |
| Tonn, JC | 1 |
| Wu, SM | 1 |
| Ren, QG | 1 |
| Zhou, MO | 1 |
| Peng, Q | 2 |
| Chen, JY | 1 |
| Bogaards, A | 1 |
| Varma, A | 1 |
| Collens, SP | 1 |
| Lin, A | 1 |
| Giles, A | 1 |
| Yang, VX | 1 |
| Bilbao, JM | 1 |
| Lilge, LD | 1 |
| Muller, PJ | 1 |
| Hirschberg, H | 1 |
| Sørensen, DR | 1 |
| Angell-Petersen, E | 1 |
| Tromberg, B | 1 |
| Sun, CH | 1 |
| Spetalen, S | 1 |
| Madsen, S | 1 |
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| Takahashi, H | 1 |
| Inoue, H | 1 |
| Shibata, MA | 1 |
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| Krivickiene, Z | 1 |
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| Kreth, FW | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488] | Phase 1 | 540 participants (Anticipated) | Interventional | 2014-07-31 | Active, not recruiting | ||
| Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas[NCT04937244] | Phase 4 | 10 participants (Anticipated) | Interventional | 2021-05-13 | Recruiting | ||
| Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker: Correlation With Preoperative MR, ALA-induced PpIX Fluorescence, and Histopathology[NCT02691923] | Phase 2 | 30 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737] | 43 participants (Actual) | Interventional | 2019-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for protoporphyrin ix and Glioma
| Article | Year |
|---|---|
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photoche | 2022 |
Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells.
Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Disease Models, Animal; Glioma; Humans; Light; Pro | 2019 |
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Mitochondria; Photosensitizing A | 2020 |
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neurons; Neurosurgical Procedure | 2016 |
[Intraoperative photo-dynamic diagnosis of brain tumors].
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat | 2009 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies.
Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Fluorescence; Glioma; Humans; Magnetic | 2012 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Ph | 2012 |
[Intraoperative photodynamic diagnosis using 5-ALA for glioma surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Monitoring, Intraoperative; Neoplasm, Residual | 2005 |
Repetitive photodynamic therapy of malignant brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Light; Photochemotherapy; Photosensit | 2006 |
[Intraoperative photodynamic diagnosis of human glioma using ALA induced protoporphyrin IX].
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Male; Mice; Middle Aged; Monitoring, | 2001 |
5 trials available for protoporphyrin ix and Glioma
| Article | Year |
|---|---|
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Craniotomy; Dose-Re | 2017 |
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye | 2018 |
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl | 2011 |
Fluorescence-guided resections of malignant gliomas--an overview.
Topics: Aminolevulinic Acid; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Fluorescenc | 2003 |
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Fluoresc | 2007 |
69 other studies available for protoporphyrin ix and Glioma
| Article | Year |
|---|---|
Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery.
Topics: Biomarkers, Tumor; Blood-Brain Barrier; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neuroglia | 2021 |
Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferr | 2022 |
Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Hyperspectral Imaging; Photosensitizing Agents | 2022 |
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Microscopy, Fluorescence; Photos | 2023 |
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.
Topics: Adolescent; Aminolevulinic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Fluorescen | 2019 |
Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; | 2019 |
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Compute | 2020 |
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fl | 2020 |
Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Fluo | 2021 |
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op | 2021 |
Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Cell | 2021 |
Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Chromosome Deletion; Female; Fluorescence; Glioma; Huma | 2022 |
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tu | 2021 |
Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescein; Fluorescence; Fluorescent Dyes; Glioma; H | 2018 |
Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Disease-Free Survival; Glioma; | 2017 |
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor | 2017 |
Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Electronic Data Processing; Glioma; Humans; Neuros | 2017 |
Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Levulinic Acids; Neurosurgical Procedures; O | 2017 |
Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biotransformation; Brain Neoplasms; Cell Line, T | 2018 |
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
Topics: Adult; Aminolevulinic Acid; Biomarkers; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma; Human | 2019 |
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent D | 2018 |
Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.
Topics: Brain; Brain Neoplasms; Equipment Design; Feasibility Studies; Glioma; Humans; Optical Imaging; Phan | 2018 |
Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Kineti | 2019 |
Optimizing 5-ALA Induced Fluorescence Visualization: Comment Regarding Recent Article on Fluorescence-Based Real-Time Kinetics Protoporphyrin-IX Measurements Article in Neurosurgery.
Topics: Aminolevulinic Acid; Fluorescence; Glioma; Humans; Kinetics; Neurosurgery; Photosensitizing Agents; | 2019 |
Is the Intensity of 5-Aminolevulinic Acid-Derived Fluorescence Related to the Light Source?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Light; Neurosurgical Procedures; | 2019 |
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R | 2013 |
System and methods for wide-field quantitative fluorescence imaging during neurosurgery.
Topics: Animals; Brain; Glioma; Neurosurgery; Protoporphyrins; Rats; Spectrometry, Fluorescence; Surgery, Co | 2013 |
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Surviv | 2013 |
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Astrocytes; Brain Neoplasms; Calcitriol; Cell Line, Tumor; Cell Survival; Enzym | 2014 |
5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Female; Fluorescence; Glioma; | 2013 |
Protoporphyrin-IX fluorescence guided surgical resection in high-grade gliomas: The potential impact of human colour perception.
Topics: Brain Neoplasms; Color Perception; Female; Fluorescent Dyes; Glioma; Humans; Male; Microscopy, Fluor | 2014 |
[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases].
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Count; Cell Line, Tumor; Female; Gl | 2014 |
5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cytoplasm; Glioma; Humans; In Vitro | 2015 |
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity, | 2015 |
Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Fluorescence; | 2015 |
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; | 2015 |
Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells.
Topics: Acrylic Resins; Cell Count; Cell Line, Tumor; Cell Proliferation; Cellular Microenvironment; Elastic | 2015 |
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Combined M | 2016 |
Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Coproporphyrinogen Oxidase; Fluorescence; Gl | 2017 |
Simultaneous
Topics: Animals; Cell Line, Tumor; ErbB Receptors; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; | 2017 |
Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
Topics: Adult; Aminolevulinic Acid; Female; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spe | 2017 |
5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.
Topics: Aminolevulinic Acid; Apoptosis; Biological Transport; Brain Neoplasms; Cell Death; Cell Line, Tumor; | 2017 |
Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biotransforma | 2017 |
Diagnostic detection of diffuse glioma tumors in vive with molecular fluorescent probe-based transmission spectroscopy.
Topics: Animals; Biophysical Phenomena; Brain Neoplasms; Cell Line, Tumor; ErbB Receptors; Fluorescent Dyes; | 2009 |
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Data Interpretation, Statisti | 2011 |
Improving intraoperative visualization of anaplastic foci within gliomas.
Topics: Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Fluorescence; Glioma; Humans; Protoporphyri | 2010 |
Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents; Protoporphyrins; Spec | 2011 |
Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Ferrochelatase; Fluorescence; Gene Silencing; Glioma; Humans; | 2011 |
Fluorescence illuminates the way ...
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Male; Monitoring, Intraope | 2011 |
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Female; Fluoresce | 2011 |
¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Carbon Radioisotopes; Cell Count; Cell Proliferat | 2012 |
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Diagnostic Imaging; Glioma; Humans; Models, Biological; Prot | 2011 |
Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Protoporphyrins; Radiation-Sensitizing Agent | 2012 |
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Memb | 2012 |
Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Contrast Media; Glioma; Mice; Mice, Nude; Microscopy, Fl | 2012 |
Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.
Topics: Aminolevulinic Acid; Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Brain; Brain N | 2013 |
Automatic laser scanning ablation system for high-precision treatment of brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Equipment Design; Glioma; Humans; Laser Therap | 2013 |
Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.
Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Craniotomy; Creatinine; Female; Gadoliniu | 2012 |
Quantitative, spectrally-resolved intraoperative fluorescence imaging.
Topics: Animals; Brain Neoplasms; Fluorescence; Fluorescent Dyes; Glioma; Humans; Intraoperative Period; Opt | 2012 |
Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line; Cerebellum; Glioma; Humans; Neuroblastoma; | 2003 |
Increased brain tumor resection using fluorescence image guidance in a preclinical model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Microscopy; Models, Animal; Neoplasm, Residua | 2004 |
[5-ALA fluorescence guided tumor resection].
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Middle Aged; Mitochondri | 2006 |
Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes | 2007 |
Two-photon photodynamic therapy of C6 cells by means of 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship | 2007 |
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Feasibility Studies; Glioma; Humans; Magnetic Res | 2007 |
Auditory alert system for fluorescence-guided resection of gliomas.
Topics: Acoustic Stimulation; Brain Neoplasms; Diagnosis, Computer-Assisted; Glioma; Humans; Neoplasm Invasi | 2008 |
5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion.
Topics: Aminolevulinic Acid; Biopsy; Fluorescence; Glioma; Humans; Prognosis; Protoporphyrins; Sensitivity a | 2008 |
Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Mi | 1998 |
In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioma; Humans; Male; Photosensitizing Agents; | 1998 |