protoporphyrin ix has been researched along with Experimental Neoplasms in 21 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colorectal cancer is of particular concern due to its high mortality rate count." | 5.62 | Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer. ( Boniewska-Bernacka, E; Dyrda, G; Janas, K; Słota, R, 2021) |
| "Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas." | 3.88 | Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching. ( Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K, 2018) |
| "The potential of protoporphyrin IX fluorescence induced by the systemic administration of delta-aminolevulinic acid (ALA) for the detection of tumours was tested in three different murine models (MS-2 fibrosarcoma, L1210 leukaemia, and Lewis lung carcinoma)." | 3.69 | delta-Aminolevulinic acid induced fluorescence in tumour-bearing mice. ( Canti, G; Cubeddu, R; Taroni, P; Valentini, G, 1995) |
| "Colorectal cancer is of particular concern due to its high mortality rate count." | 1.62 | Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer. ( Boniewska-Bernacka, E; Dyrda, G; Janas, K; Słota, R, 2021) |
| "Comparison of the fluorescence intensity caused by the accumulation of PpIX in endometrial cancer xenografts in nude mice after low-dose 5-Aminolevulinic acid (ALA) injection combined with siRNA transfection was mediated by ultrasound microbubbles and polyethyleneimine (PEI) to explore the feasibility of the ultrasound microbubble technique as transfection agents." | 1.51 | Comparative Study of the Effects of Ferrochelatase-siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low-dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models. ( Chen, L; Gao, L; Gao, X; Huang, X; Li, N; Lin, S; Song, Y; Wang, X; Zhang, X, 2019) |
| "The mean number of metastases detected by the PDD was significantly higher than that of white light for FT821 (p=0." | 1.37 | 5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor. ( Ali, AH; Kakiuchi, S; Kenzaki, K; Kondo, K; Matsuoka, H; Nakagawa, Y; Sakiyama, S; Sekido, Y; Sone, S; Takizawa, H; Tangoku, A; Toba, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Janas, K | 1 |
| Boniewska-Bernacka, E | 1 |
| Dyrda, G | 1 |
| Słota, R | 1 |
| Belykh, E | 1 |
| Miller, EJ | 1 |
| Patel, AA | 1 |
| Bozkurt, B | 1 |
| Yağmurlu, K | 1 |
| Robinson, TR | 1 |
| Nakaji, P | 1 |
| Spetzler, RF | 1 |
| Lawton, MT | 1 |
| Nelson, LY | 1 |
| Seibel, EJ | 1 |
| Preul, MC | 1 |
| Zhang, X | 1 |
| Chen, L | 1 |
| Gao, L | 1 |
| Gao, X | 1 |
| Li, N | 1 |
| Song, Y | 1 |
| Huang, X | 1 |
| Lin, S | 1 |
| Wang, X | 1 |
| Hirano, T | 1 |
| Hagiya, Y | 1 |
| Fukuhara, H | 1 |
| Inoue, K | 2 |
| Shuin, T | 1 |
| Matsumoto, K | 1 |
| Tanaka, T | 2 |
| Okura, I | 1 |
| Ogura, S | 1 |
| Uto, Y | 1 |
| Tamatani, D | 1 |
| Mizuki, Y | 1 |
| Endo, Y | 1 |
| Nakanishi, I | 1 |
| Ohkubo, K | 1 |
| Fukuzumi, S | 1 |
| Ishizuka, M | 1 |
| Kuchiike, D | 1 |
| Kubo, K | 1 |
| Inui, T | 1 |
| Hori, H | 1 |
| Kiesslich, T | 1 |
| Helander, L | 1 |
| Illig, R | 1 |
| Oberdanner, C | 1 |
| Wagner, A | 1 |
| Lettner, H | 1 |
| Jakab, M | 1 |
| Plaetzer, K | 1 |
| Mallidi, S | 1 |
| Mai, Z | 1 |
| Rizvi, I | 2 |
| Hempstead, J | 1 |
| Arnason, S | 1 |
| Celli, J | 1 |
| Hasan, T | 3 |
| Nair, LV | 1 |
| Nazeer, SS | 1 |
| Jayasree, RS | 1 |
| Ajayaghosh, A | 1 |
| Li, SY | 1 |
| Cheng, H | 1 |
| Xie, BR | 1 |
| Qiu, WX | 1 |
| Song, LL | 1 |
| Zhuo, RX | 1 |
| Zhang, XZ | 1 |
| Singh, S | 1 |
| Jha, P | 1 |
| Singh, V | 1 |
| Sinha, K | 1 |
| Hussain, S | 1 |
| Singh, MK | 1 |
| Das, P | 1 |
| Donnelly, RF | 1 |
| McCarron, PA | 1 |
| Al-Kassas, R | 1 |
| Juzeniene, A | 1 |
| Juzenas, P | 1 |
| Iani, V | 1 |
| Woolfson, AD | 1 |
| Moan, J | 1 |
| Anand, S | 1 |
| Honari, G | 1 |
| Elson, P | 1 |
| Maytin, EV | 1 |
| Reeves, KJ | 1 |
| Reed, MW | 1 |
| Brown, NJ | 1 |
| Ali, AH | 1 |
| Takizawa, H | 1 |
| Kondo, K | 1 |
| Matsuoka, H | 1 |
| Toba, H | 1 |
| Nakagawa, Y | 1 |
| Kenzaki, K | 1 |
| Sakiyama, S | 1 |
| Kakiuchi, S | 1 |
| Sekido, Y | 1 |
| Sone, S | 1 |
| Tangoku, A | 1 |
| Wang, LY | 1 |
| Shi, XY | 1 |
| Yang, CS | 1 |
| Huang, DM | 1 |
| Solban, N | 1 |
| Cubeddu, R | 1 |
| Canti, G | 1 |
| Taroni, P | 1 |
| Valentini, G | 1 |
| Johansson, J | 1 |
| Berg, R | 1 |
| Svanberg, K | 1 |
| Svanberg, S | 1 |
| Casas, A | 1 |
| Perotti, C | 1 |
| Fukuda, H | 1 |
| Rogers, L | 1 |
| Butler, AR | 1 |
| Batlle, A | 1 |
| Bedwell, J | 1 |
| MacRobert, AJ | 1 |
| Phillips, D | 1 |
| Bown, SG | 1 |
| Mathews-Roth, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas[NCT04937244] | Phase 4 | 10 participants (Anticipated) | Interventional | 2021-05-13 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for protoporphyrin ix and Experimental Neoplasms
| Article | Year |
|---|---|
Targeted photodynamic therapy.
Topics: Animals; Antibodies, Monoclonal; Drug Delivery Systems; ErbB Receptors; Neoplasms, Experimental; Pho | 2006 |
Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adolescent; Adult; Animals; Bacteria; Bacterial Physiological Phen | 1986 |
19 other studies available for protoporphyrin ix and Experimental Neoplasms
| Article | Year |
|---|---|
Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neop | 2021 |
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent D | 2018 |
Comparative Study of the Effects of Ferrochelatase-siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low-dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Endometrial Neoplasms; Female; Ferrochelatase; Human | 2019 |
Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Drug Combinations; Drug Synergism; Humans; Image Enhancement; | 2013 |
Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chick Embryo; Metalloporphyrins; Mice; Neoplasms, Ex | 2014 |
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Survival; Computer Systems; Dose-Response Rel | 2014 |
In vivo evaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints.
Topics: Animals; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Line, Tumor; Electric P | 2015 |
Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer-Linked Gold Quantum Clusters.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Fluorescence; Gold; | 2015 |
A ratiometric theranostic probe for tumor targeting therapy and self-therapeutic monitoring.
Topics: Animals; Chlorocebus aethiops; COS Cells; Drug Monitoring; Fluorescence Resonance Energy Transfer; N | 2016 |
A quantum dot-MUC1 aptamer conjugate for targeted delivery of protoporphyrin IX and specific photokilling of cancer cells through ROS generation.
Topics: Animals; Apoptosis; Aptamers, Nucleotide; HeLa Cells; Humans; Mice; Molecular Targeted Therapy; Nano | 2016 |
Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Female; Gels; Mice; Mice, Inbred BALB C; Mi | 2009 |
Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Antimetabolites, Antineoplastic; Blo | 2009 |
The role of nitric oxide in the treatment of tumours with aminolaevulinic acid-induced photodynamic therapy.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cell Line, Tumor; Mice; Mice, Inbred BALB C; Mic | 2010 |
5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor.
Topics: Aminolevulinic Acid; Animals; Carcinoma; Cell Line, Tumor; Fluorescence; Humans; Lung Neoplasms; Mes | 2011 |
Versatile RBC-derived vesicles as nanoparticle vector of photosensitizers for photodynamic therapy.
Topics: Cell Line, Tumor; Cells, Cultured; Erythrocytes; Humans; Nanocapsules; Neoplasms, Experimental; Phot | 2013 |
delta-Aminolevulinic acid induced fluorescence in tumour-bearing mice.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Lewis Lung; Female; Fibrosarcoma; Fluorescence; Hematoporph | 1995 |
Laser-induced fluorescence studies of normal and malignant tumour tissue of rat following intravenous injection of delta-amino levulinic acid.
Topics: Aminolevulinic Acid; Animals; Injections, Intravenous; Lasers; Muscles; Neoplasms, Experimental; Pro | 1997 |
ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Female; Kidney; Liver; Mice; Neoplas | 2001 |
Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Intestinal Mucosa; Microscopy, Fluorescence; Neopla | 1992 |