protoporphyrin ix has been researched along with Condition, Preneoplastic in 21 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Surveillance of patients with Barrett's esophagus or ulcerative colitis for dysplasia is confined to biopsy specimens taken randomly during endoscopy because dysplasia remains undetectable by visual inspection." | 5.30 | Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization. ( Bäumler, W; Holstege, A; Knüchel, R; Messmann, H; Schölmerich, J, 1999) |
| "Four patients with known gastric adenoma (n = 1), macroscopically undetected but histologically proven esophageal squamous cell cancer (n = 1), suspected early cancer of the esophagus (n = 1), and multiple duodenal adenomas (n = 1) were sensitized with 5-aminolevulinic acid administered orally (15 mg/kg body weight)." | 3.70 | Endoscopic photodynamic diagnosis: oral aminolevulinic acid is a marker of GI cancer and dysplastic lesions. ( Hahn, EG; Hochberger, J; Mayinger, B; Reh, H, 1999) |
| "Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX was found as a valuable tool in the diagnosis of oral premalignancy." | 2.72 | Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy. ( El-Maaytah, M; Hopper, C; Jerjes, W; Khalil, HS; MacRobert, AJ; Salih, V; Sharwani, A, 2006) |
| "It will be the aim of further investigations to verify the optimal time of incubation and dosing of systemical 5-ALA application to enhance fluorescence contrasts and set the basis for fluorescence guided resections." | 1.31 | [Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid]. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Leunig, A, 2002) |
| "Surveillance of patients with Barrett's esophagus or ulcerative colitis for dysplasia is confined to biopsy specimens taken randomly during endoscopy because dysplasia remains undetectable by visual inspection." | 1.30 | Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization. ( Bäumler, W; Holstege, A; Knüchel, R; Messmann, H; Schölmerich, J, 1999) |
| "Following transurethral resection of bladder cancer, the fate of patients is clearly related to the presence or absence of precancerous or malignant lesions in the remaining mucosa." | 1.29 | [Photodynamic diagnosis of urothelial neoplasms after intravesicular instillation of 5-aminolevulinic acid]. ( Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knüchel, R; Kriegmair, M; Lumper, W; Steinbach, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yeh, SC | 1 |
| Sahli, S | 1 |
| Andrews, DW | 1 |
| Patterson, MS | 1 |
| Armstrong, D | 1 |
| Provias, J | 1 |
| Fang, Q | 1 |
| Liutkeviciūte-Navickiene, J | 1 |
| Mordas, A | 1 |
| Simkute, S | 1 |
| Bloznelyte-Plesniene, L | 1 |
| Tyrrell, J | 1 |
| Campbell, S | 1 |
| Curnow, A | 3 |
| Tyrrell, JS | 1 |
| Morton, C | 1 |
| Campbell, SM | 1 |
| Togsverd-Bo, K | 1 |
| Lerche, CM | 1 |
| Philipsen, PA | 1 |
| Poulsen, T | 1 |
| Wulf, HC | 1 |
| Haedersdal, M | 1 |
| Blake, E | 1 |
| Allen, J | 1 |
| Thorn, C | 1 |
| Shore, A | 1 |
| Brand, S | 1 |
| Wang, TD | 1 |
| Schomacker, KT | 1 |
| Poneros, JM | 1 |
| Lauwers, GY | 1 |
| Compton, CC | 1 |
| Pedrosa, MC | 1 |
| Nishioka, NS | 1 |
| Leunig, A | 1 |
| Betz, CS | 1 |
| Heinrich, P | 1 |
| Janda, P | 1 |
| Baumgartner, R | 3 |
| Ortner, MA | 1 |
| Ebert, B | 1 |
| Hein, E | 1 |
| Zumbusch, K | 1 |
| Nolte, D | 1 |
| Sukowski, U | 1 |
| Weber-Eibel, J | 1 |
| Fleige, B | 1 |
| Dietel, M | 1 |
| Stolte, M | 1 |
| Oberhuber, G | 1 |
| Porschen, R | 1 |
| Klump, B | 1 |
| Hörtnagl, H | 1 |
| Lochs, H | 2 |
| Rinneberg, H | 1 |
| Csanády, M | 1 |
| Kiss, JG | 1 |
| Iván, L | 1 |
| Jóri, J | 1 |
| Czigner, J | 1 |
| Knüchel, R | 5 |
| Hartmann, A | 1 |
| Stöhr, R | 1 |
| Zaak, D | 1 |
| Krieg, RC | 1 |
| Zheng, W | 1 |
| Olivo, M | 1 |
| Soo, KC | 1 |
| Endlicher, E | 2 |
| Gelbmann, CM | 1 |
| Fürst, A | 1 |
| Szeimies, RM | 2 |
| Gölder, SK | 1 |
| Schölmerich, J | 3 |
| Lottner, C | 1 |
| Messmann, H | 4 |
| Sharwani, A | 1 |
| Jerjes, W | 1 |
| Salih, V | 1 |
| MacRobert, AJ | 1 |
| El-Maaytah, M | 1 |
| Khalil, HS | 1 |
| Hopper, C | 1 |
| Kriegmair, M | 1 |
| Ehsan, A | 1 |
| Steinbach, P | 1 |
| Lumper, W | 1 |
| Hofstädter, F | 1 |
| Hofstetter, A | 1 |
| Ortner, M | 1 |
| Hauser, T | 1 |
| Kullmann, F | 1 |
| Bäumler, W | 2 |
| Hinnen, P | 1 |
| de Rooij, FW | 1 |
| van Velthuysen, ML | 1 |
| Edixhoven, A | 1 |
| van Hillegersberg, R | 1 |
| Tilanus, HW | 1 |
| Wilson, JH | 1 |
| Siersema, PD | 1 |
| Holstege, A | 1 |
| Mayinger, B | 1 |
| Reh, H | 1 |
| Hochberger, J | 1 |
| Hahn, EG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737] | 43 participants (Actual) | Interventional | 2019-11-01 | Completed | |||
| Portable Measurement of Protoporphyrin IX in the Skin[NCT04223570] | 218 participants (Anticipated) | Observational | 2022-12-01 | Enrolling by invitation | |||
| The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics (PDD): a Clinical Pilot Study[NCT03272659] | Phase 2 | 0 participants (Actual) | Interventional | 2018-04-01 | Withdrawn (stopped due to Long process and due to strict deadline, project was stopped.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for protoporphyrin ix and Condition, Preneoplastic
| Article | Year |
|---|---|
5-Aminolevulinic acid-induced protoporphyrin IX for the detection of gastrointestinal dysplasia.
Topics: Aminolevulinic Acid; Animals; Endoscopy, Gastrointestinal; Gastrointestinal Neoplasms; Humans; Intes | 2000 |
4 trials available for protoporphyrin ix and Condition, Preneoplastic
| Article | Year |
|---|---|
Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Photobleaching; Photochemotherap | 2010 |
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo | 2011 |
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo | 2011 |
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo | 2011 |
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo | 2011 |
Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Oxygen; Pho | 2013 |
Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Humans; Middle Aged; Mouth Neoplasms; P | 2006 |
16 other studies available for protoporphyrin ix and Condition, Preneoplastic
| Article | Year |
|---|---|
5-Aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models.
Topics: Adenocarcinoma; Algorithms; Aminolevulinic Acid; Barrett Esophagus; Biomarkers; Esophageal Neoplasms | 2015 |
[Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell | 2009 |
Porphyrin biodistribution in UV-exposed murine skin after methyl- and hexyl-aminolevulinate incubation.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Availability; Female; Humans; Mice | 2012 |
Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esopha | 2002 |
[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid].
Topics: Administration, Inhalation; Administration, Oral; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous C | 2002 |
Time gated fluorescence spectroscopy in Barrett's oesophagus.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Biomarkers, | 2003 |
ALA (5-aminolevulinic acid)-induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer.
Topics: Adult; Aged; Aminolevulinic Acid; Diagnosis, Differential; Female; Fluorescence; Humans; Laryngeal N | 2004 |
[Precancerous conditions in the urothelium. Early detection and molecular understanding through endoscopic fluorescence diagnosis].
Topics: Coloring Agents; Diagnosis, Differential; Fluorescent Dyes; Humans; Kidney Neoplasms; Microscopy, Fl | 2003 |
The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Diagnostic Imaging; Endoscopy; Female; Fluoresc | 2004 |
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformatio | 2004 |
[Photodynamic diagnosis of urothelial neoplasms after intravesicular instillation of 5-aminolevulinic acid].
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma | 1994 |
[Eradication of high-grade dysplasia in Barrett esophagus by photodynamic therapy with endogenously generated protoporphyrin IX].
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Fe | 1998 |
[Photodynamic diagnosis of gastrointestinal precancerous lesions after sensitization with 5-aminolevulinic acid. A pilot study].
Topics: Adenoma; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Colitis, Ulcerative; Colorectal Neopla | 1998 |
Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.
Topics: Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Female; Ferroc | 1998 |
Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization.
Topics: Adenomatous Polyps; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Colitis, Ulcerative | 1999 |
Endoscopic photodynamic diagnosis: oral aminolevulinic acid is a marker of GI cancer and dysplastic lesions.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Duodenal Neoplasms; Endoscopy, Digesti | 1999 |