protoporphyrin ix has been researched along with Colorectal Cancer in 13 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Folic acid can be covalently conjugated to chitosan molecules via its gamma-carboxyl moiety and thus retain a high affinity for colorectal cancer cells bearing folate receptor overexpression." | 7.76 | Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. ( Lin, FH; Shieh, MJ; Tsai, HM; Tsai, KC; Wei, MF; Wong, JM; Yang, SJ, 2010) |
| "We detected the concentration of protoporphyrin IX in 30 patients with colorectal cancer and 30 control patients, as well as that in 60 cases of intestinal tissues (30 control tissues and 30 cancer tissues)." | 7.75 | Concentration of protoporphyrin IX in cancer tissues and blood in patients with colorectal cancer at early stage. ( Jia, Z; Wan, X, 2009) |
| "Colorectal cancer is of particular concern due to its high mortality rate count." | 5.62 | Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer. ( Boniewska-Bernacka, E; Dyrda, G; Janas, K; Słota, R, 2021) |
| "Protoporphyrin IX (PpIX) was identified as the predominant fluorophore in primary tumors and their metastases." | 5.31 | Protoporphyrin IX occurs naturally in colorectal cancers and their metastases. ( Dougherty, TJ; Ebert, B; Haensch, WE; Handke, T; Moesta, KT; Nolte, D; Nowak, C; Pandey, RK; Rinneberg, H; Schlag, PM, 2001) |
| "5-aminolevulinic acid (5-ALA)-based fluorescence diagnosis is now clinically applied for accurate and ultrarapid diagnosis of malignant lesions such as lymph node metastasis during surgery." | 3.83 | Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions. ( Harada, Y; Kato, Y; Matsuo, H; Minamikawa, T; Otsuji, E; Takamatsu, T; Tanaka, H; Yanagisawa, A, 2016) |
| "Folic acid can be covalently conjugated to chitosan molecules via its gamma-carboxyl moiety and thus retain a high affinity for colorectal cancer cells bearing folate receptor overexpression." | 3.76 | Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. ( Lin, FH; Shieh, MJ; Tsai, HM; Tsai, KC; Wei, MF; Wong, JM; Yang, SJ, 2010) |
| "We detected the concentration of protoporphyrin IX in 30 patients with colorectal cancer and 30 control patients, as well as that in 60 cases of intestinal tissues (30 control tissues and 30 cancer tissues)." | 3.75 | Concentration of protoporphyrin IX in cancer tissues and blood in patients with colorectal cancer at early stage. ( Jia, Z; Wan, X, 2009) |
| "Colorectal cancer is of particular concern due to its high mortality rate count." | 1.62 | Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer. ( Boniewska-Bernacka, E; Dyrda, G; Janas, K; Słota, R, 2021) |
| "5-ALA fluorescence was detected in all hepatocellular carcinoma cases with serosa invasion." | 1.40 | Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience. ( Hayashi, M; Hirokawa, F; Inoue, Y; Komeda, K; Tanaka, R; Uchiyama, K, 2014) |
| "In this study, CSCs were isolated from colorectal cancer cells using PROM1/CD133 (prominin 1) expression, which is a surface marker commonly found on stem cells of various tissues." | 1.40 | Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. ( Chen, KC; Chen, MW; Hsiao, M; Hung, SC; Lin, SY; Lou, PJ; Shieh, MJ; Wei, MF; Yao, CJ, 2014) |
| "Protoporphyrin IX (PpIX) was identified as the predominant fluorophore in primary tumors and their metastases." | 1.31 | Protoporphyrin IX occurs naturally in colorectal cancers and their metastases. ( Dougherty, TJ; Ebert, B; Haensch, WE; Handke, T; Moesta, KT; Nolte, D; Nowak, C; Pandey, RK; Rinneberg, H; Schlag, PM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Janas, K | 1 |
| Boniewska-Bernacka, E | 1 |
| Dyrda, G | 1 |
| Słota, R | 1 |
| Matsuo, H | 2 |
| Harada, Y | 3 |
| Minamikawa, T | 3 |
| Kato, Y | 2 |
| Murayama, Y | 2 |
| Otsuji, E | 3 |
| Takamatsu, T | 3 |
| Tanaka, H | 2 |
| Lualdi, M | 1 |
| Cavalleri, A | 1 |
| Battaglia, L | 1 |
| Colombo, A | 1 |
| Garrone, G | 1 |
| Morelli, D | 1 |
| Pignoli, E | 1 |
| Sottotetti, E | 1 |
| Leo, E | 1 |
| Harada, K | 1 |
| Beika, M | 1 |
| Koizumi, N | 1 |
| Inoue, K | 1 |
| Kuriu, Y | 1 |
| Nakanishi, M | 1 |
| Yamaoka, Y | 1 |
| Dai, P | 1 |
| Yanagisawa, A | 2 |
| Inoue, Y | 1 |
| Tanaka, R | 1 |
| Komeda, K | 1 |
| Hirokawa, F | 1 |
| Hayashi, M | 1 |
| Uchiyama, K | 1 |
| Wei, MF | 2 |
| Chen, MW | 1 |
| Chen, KC | 1 |
| Lou, PJ | 1 |
| Lin, SY | 1 |
| Hung, SC | 1 |
| Hsiao, M | 1 |
| Yao, CJ | 1 |
| Shieh, MJ | 2 |
| Jia, Z | 1 |
| Wan, X | 1 |
| Yang, SJ | 1 |
| Lin, FH | 1 |
| Tsai, KC | 1 |
| Tsai, HM | 1 |
| Wong, JM | 1 |
| Wan, K | 1 |
| Ebert, B | 2 |
| Voigt, J | 1 |
| Wang, Q | 1 |
| Dai, Y | 1 |
| Haag, R | 1 |
| Kemmner, W | 1 |
| Endlicher, E | 2 |
| Gelbmann, CM | 1 |
| Knüchel, R | 2 |
| Fürst, A | 1 |
| Szeimies, RM | 2 |
| Gölder, SK | 1 |
| Schölmerich, J | 2 |
| Lottner, C | 1 |
| Messmann, H | 2 |
| Hauser, T | 1 |
| Kullmann, F | 1 |
| Bäumler, W | 1 |
| Moesta, KT | 1 |
| Handke, T | 1 |
| Nolte, D | 1 |
| Nowak, C | 1 |
| Haensch, WE | 1 |
| Pandey, RK | 1 |
| Dougherty, TJ | 1 |
| Rinneberg, H | 1 |
| Schlag, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics (PDD): a Clinical Pilot Study[NCT03272659] | Phase 2 | 0 participants (Actual) | Interventional | 2018-04-01 | Withdrawn (stopped due to Long process and due to strict deadline, project was stopped.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for protoporphyrin ix and Colorectal Cancer
| Article | Year |
|---|---|
Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neop | 2021 |
Efficient fluorescence detection of protoporphyrin IX in metastatic lymph nodes of murine colorectal cancer stained with indigo carmine.
Topics: Animals; Colorectal Neoplasms; Coloring Agents; Indigo Carmine; Lymph Nodes; Mice; Neoplasm Metastas | 2017 |
Early detection of colorectal adenocarcinoma: a clinical decision support tool based on plasma porphyrin accumulation and risk factors.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Coproporphyrins; Early Diagnos | 2018 |
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Colorectal Neoplasms; Female; Fluorescence; Hum | 2013 |
Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience.
Topics: Aged; Aminolevulinic Acid; Anastomotic Leak; Carcinoma, Hepatocellular; Color; Colorectal Neoplasms; | 2014 |
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Apoptosis; Autophagy; Carcinogenesis; Chloroquine; Colorectal | 2014 |
Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions.
Topics: Aminolevulinic Acid; Biotransformation; Cell Line, Tumor; Collagen; Colorectal Neoplasms; Flavins; F | 2016 |
Concentration of protoporphyrin IX in cancer tissues and blood in patients with colorectal cancer at early stage.
Topics: Case-Control Studies; Colorectal Neoplasms; Female; Humans; Male; Protoporphyrins; Spectrometry, Flu | 2009 |
Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells.
Topics: Aminolevulinic Acid; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Chitosan; Colorectal Neoplasm | 2010 |
In vivo tumor imaging using a novel RNAi-based detection mechanism.
Topics: Animals; Colorectal Neoplasms; Female; Ferrochelatase; Fluorescence; Humans; Mice; Mice, Nude; Nanop | 2012 |
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformatio | 2004 |
[Photodynamic diagnosis of gastrointestinal precancerous lesions after sensitization with 5-aminolevulinic acid. A pilot study].
Topics: Adenoma; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Colitis, Ulcerative; Colorectal Neopla | 1998 |
Protoporphyrin IX occurs naturally in colorectal cancers and their metastases.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Female; | 2001 |