protoporphyrin ix has been researched along with Cell Transformation, Neoplastic in 5 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA)." | 7.75 | Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. ( Dziadziuszko, H; Glosnicka, R; Graczyk, A; Jankowski, D; Jaskiewicz, K; Juzeniene, A; Kaliszewski, M; Kunikowska, D; Kwasny, M; Kwitniewski, M; Ma, LW; Moan, J; Peksa, R, 2009) |
| " Treatment with 2500 ppm ACI for 26 weeks after initiation with diethylnitrosamine increased the incidence and multiplicities of altered foci and adenomas in hepatocytes from WT mice; these effects were significantly reduced in CARKO mice." | 3.83 | Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. ( Ichimura, R; Inoue, K; Kodama, Y; Kuwata, K; Shibutani, M; Takahashi, M; Yoshida, M, 2016) |
| " In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA)." | 3.75 | Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. ( Dziadziuszko, H; Glosnicka, R; Graczyk, A; Jankowski, D; Jaskiewicz, K; Juzeniene, A; Kaliszewski, M; Kunikowska, D; Kwasny, M; Kwitniewski, M; Ma, LW; Moan, J; Peksa, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuwata, K | 1 |
| Inoue, K | 1 |
| Ichimura, R | 1 |
| Takahashi, M | 1 |
| Kodama, Y | 1 |
| Shibutani, M | 1 |
| Yoshida, M | 1 |
| Yang, X | 1 |
| Palasuberniam, P | 1 |
| Myers, KA | 1 |
| Wang, C | 1 |
| Chen, B | 1 |
| Kwitniewski, M | 1 |
| Jankowski, D | 1 |
| Jaskiewicz, K | 1 |
| Dziadziuszko, H | 1 |
| Juzeniene, A | 1 |
| Moan, J | 1 |
| Ma, LW | 1 |
| Peksa, R | 1 |
| Kunikowska, D | 1 |
| Graczyk, A | 1 |
| Kwasny, M | 1 |
| Kaliszewski, M | 1 |
| Glosnicka, R | 1 |
| Endlicher, E | 1 |
| Gelbmann, CM | 1 |
| Knüchel, R | 1 |
| Fürst, A | 1 |
| Szeimies, RM | 1 |
| Gölder, SK | 1 |
| Schölmerich, J | 1 |
| Lottner, C | 1 |
| Messmann, H | 1 |
| Li, G | 1 |
| Szewczuk, MR | 1 |
| Raptis, L | 1 |
| Johnson, JG | 1 |
| Weagle, GE | 1 |
| Pottier, RH | 1 |
| Kennedy, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics (PDD): a Clinical Pilot Study[NCT03272659] | Phase 2 | 0 participants (Actual) | Interventional | 2018-04-01 | Withdrawn (stopped due to Long process and due to strict deadline, project was stopped.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for protoporphyrin ix and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cell Transformation, Neoplastic | 2016 |
Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplas | 2016 |
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformatio | 2004 |
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.
Topics: 3T3 Cells; Aminolevulinic Acid; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Ce | 1999 |