Page last updated: 2024-11-03

protoporphyrin ix and Carcinoma, Basal Cell

protoporphyrin ix has been researched along with Carcinoma, Basal Cell in 35 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)

Research Excerpts

ExcerptRelevanceReference
"In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain."7.74Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. ( Cottrell, WJ; Foster, TH; Keymel, KR; Oseroff, AR; Paquette, AD, 2008)
"In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain."3.74Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. ( Cottrell, WJ; Foster, TH; Keymel, KR; Oseroff, AR; Paquette, AD, 2008)
" This method of enhancement was safely applied to a clinical PDT protocol with no unexpected adverse effects reported."2.73Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma. ( Campbell, S; Curnow, A; Pye, A, 2008)
"Of the 60 patients (20 Bowen's disease, 20 SCC, and 20 BCC), malignant neoplasms could be clearly distinguished from adjacent healthy tissue under fluorescence illumination (P < 0."1.48Topical application of Photofrin ( Chang, CJ; Chiang, YF; Hsiao, YC; Lin, YT, 2018)
" However, in the case of deep, nodular-ulcerative lesions, the complete response rates are lower, possibly related to a lower bioavailability of PpIX."1.35Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma. ( Ballini, JP; Dögnitz, N; Gabrecht, T; Lange, N; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2008)
"Calcitriol pretreatment of the cells elevated their PpIX levels."1.35Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells. ( Cicarma, E; Juzeniene, A; Ma, LW; Moan, J; Tuorkey, M, 2009)
"Ten basal cell carcinomas were coated with an ointment containing 10% ALA prior to excision; five served as controls."1.29Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. ( Landthaler, M; Sassy, T; Szeimies, RM, 1994)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (22.86)18.2507
2000's14 (40.00)29.6817
2010's12 (34.29)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Stringasci, MD1
Salvio, AG1
Moriyama, LT1
Vollet-Filho, JD1
Fortunato, TC1
Bagnato, VS1
Kurachi, C1
Lin, YT1
Hsiao, YC1
Chiang, YF1
Chang, CJ1
Salas-García, I2
Fanjul-Vélez, F2
Arce-Diego, JL2
Salas-García, T1
López-Gómez, A1
Dorado-Fernández, M1
Ruiz-Martínez, J1
Kulyk, O1
Ibbotson, SH1
Moseley, H2
Valentine, RM2
Samuel, ID1
El Hoshy, K1
Bosseila, M1
El Sharkawy, D1
Sobhi, R1
Cottrell, WJ2
Paquette, AD1
Keymel, KR1
Foster, TH2
Oseroff, AR2
Dögnitz, N1
Salomon, D1
Zellweger, M1
Ballini, JP1
Gabrecht, T1
Lange, N1
van den Bergh, H1
Wagnières, G1
de Haas, ER2
de Bruijn, HS1
Sterenborg, HJ2
Neumann, HA2
Robinson, DJ2
Cicarma, E1
Tuorkey, M1
Juzeniene, A1
Ma, LW1
Moan, J2
Wang, KK1
Mitra, S1
Liutkeviciūte-Navickiene, J1
Mordas, A1
Simkute, S1
Bloznelyte-Plesniene, L1
Lee, CY1
Kim, KH1
Kim, YH1
Ortega-Quijano, N1
Brown, CT1
Ibbotson, S1
Wood, K1
van der Beek, N1
de Leeuw, J1
Demmendal, C1
Bjerring, P1
Gaál, M1
Kui, R1
Hunyadi, Z1
Kemény, L1
Gyulai, R1
Blake, E2
Allen, J2
Thorn, C1
Shore, A1
Curnow, A3
Campbell, S2
Mathew, J1
Helliwell, P1
Choudry, K1
Brooke, RC1
Farrar, W1
Rhodes, LE1
Shen, SC1
Lee, WR1
Fang, YP1
Hu, CH1
Fang, JY1
Thompson, MS1
Andersson-Engels, S4
Svanberg, S4
Johansson, T1
Palsson, S1
Bendsoe, N1
Derjabo, A1
Kapostins, J1
Stenram, U1
Spigulis, J1
Svanberg, K4
Star, WM1
van't Veen, AJ1
Munte, K1
Won, Y1
Hong, SH1
Yu, HY1
Kwon, YH1
Yun, SJ1
Lee, SC1
Lee, JB1
Pye, A1
Roberts, DJ1
Cairnduff, F1
Szeimies, RM1
Sassy, T1
Landthaler, M1
Martin, A2
Tope, WD2
Grevelink, JM1
Starr, JC1
Fewkes, JL1
Flotte, TJ1
Deutsch, TF1
Anderson, RR2
Heyerdahl, H1
Wang, I3
Liu, DL1
Berg, R1
Peng, Q1
Ross, EV1
Kollias, N1
Gillies, R1
Wennberg, AM1
Gudmundson, F1
Stenquist, B1
Ternesten, A1
Mölne, L1
Rosén, A1
Larko, O1
af Klinteberg, C2
Enejder, AM1
Canti, G1
Cubeddu, R1
Eker, C1
Pifferi, A1
Taroni, P1
Valentini, G1
Fischer, F1
Dickson, EF1
Kennedy, JC2
Pottier, RH2
Pross, DC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Fluorescence and Thermal Imaging of the Skin Before and During Photodynamic Therapy[NCT03167762]18 participants (Actual)Interventional2017-06-22Completed
Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ[NCT03025724]40 participants (Anticipated)Interventional2017-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for protoporphyrin ix and Carcinoma, Basal Cell

ArticleYear
Daylight photodynamic therapy.
    Actas dermo-sifiliograficas, 2015, Volume: 106, Issue:8

    Topics: Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Meteorological Concepts; Photochemotherapy; Photo

2015
[Fluorescence diagnosis of non-melanoma skin cancer].
    Orvosi hetilap, 2012, Aug-26, Volume: 153, Issue:34

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous

2012
Photodynamic therapy of primary skin cancer: a review.
    British journal of plastic surgery, 1995, Volume: 48, Issue:6

    Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents; Bowen's Disease; Carcinoma, Basal Cell; Female; Fo

1995

Trials

14 trials available for protoporphyrin ix and Carcinoma, Basal Cell

ArticleYear
Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Optical Imaging; Photosensit

2015
PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: an intra-patient direct comparison study.
    Lasers in surgery and medicine, 2012, Volume: 44, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Bowen's Disease; Carcinoma; Carcinoma, Basal Cell; False Neg

2012
Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
    Lasers in medical science, 2013, Volume: 28, Issue:3

    Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Oxygen; Pho

2013
The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device.
    Journal of photochemistry and photobiology. B, Biology, 2012, Dec-05, Volume: 117

    Topics: Aminolevulinic Acid; Biological Transport; Carcinoma, Basal Cell; Injections; Oxygen; Photosensitizi

2012
The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5-aminolaevulinic acid photodynamic therapy.
    The British journal of dermatology, 2003, Volume: 149, Issue:1

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Car

2003
Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; Lasers; Male;

2006
Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using two light fractions with a two-hour interval: long-term follow-up.
    Acta dermato-venereologica, 2006, Volume: 86, Issue:5

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; M

2006
Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma.
    Journal of cancer research and clinical oncology, 2008, Volume: 134, Issue:8

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Cell Line, Tumor; Humans; In Vi

2008
Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment.
    Archives of dermatological research, 1995, Volume: 287, Issue:7

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Male;

1995
Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Basal Cell; Drug Interactions; Fluorescence; H

1998
In vivo detection of basal cell carcinoma using imaging spectroscopy.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:1

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Basal Ce

1999
Kinetic fluorescence studies of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in basal cell carcinomas.
    Journal of photochemistry and photobiology. B, Biology, 1999, Volume: 49, Issue:2-3

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell;

1999
Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin.
    Lasers in surgery and medicine, 2000, Volume: 26, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Male; Photosensi

2000
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
    Journal of photochemistry and photobiology. B, Biology, 1990, Volume: 6, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis; Ph

1990

Other Studies

18 other studies available for protoporphyrin ix and Carcinoma, Basal Cell

ArticleYear
Energy analysis of PDT using thermography during the treatment of basal cell carcinoma.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 29

    Topics: Aged; Carcinoma, Basal Cell; Female; Humans; Male; Middle Aged; Optical Imaging; Photochemotherapy;

2020
Topical application of Photofrin
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2018, Volume: 71, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Bowen's Disease; Carcinoma, Basal Cell; Dihematoporphyrin Ether; Fem

2018
Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy.
    Optics letters, 2014, Apr-01, Volume: 39, Issue:7

    Topics: Carcinoma, Basal Cell; Humans; Models, Biological; Photochemical Processes; Photochemotherapy; Photo

2014
Can basal cell carcinoma lateral border be determined by fluorescence diagnosis?: Verification by Mohs micrographic surgery.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 14

    Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Diagnostic Techniques, Surgical; Female; Fl

2016
Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jul-15, Volume: 14, Issue:14

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Huma

2008
Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma.
    Journal of photochemistry and photobiology. B, Biology, 2008, Dec-11, Volume: 93, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Dose-Response Relationship, Dru

2008
Microscopic distribution of protoporphyrin (PpIX) fluorescence in superficial basal cell carcinoma during light-fractionated aminolaevulinic acid photodynamic therapy.
    Acta dermato-venereologica, 2008, Volume: 88, Issue:6

    Topics: Aminolevulinic Acid; Biopsy; Carcinoma, Basal Cell; Humans; Immunohistochemistry; Ki-67 Antigen; Mic

2008
Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells.
    The British journal of dermatology, 2009, Volume: 161, Issue:2

    Topics: Aminolevulinic Acid; Calcitriol; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Line, Tumor;

2009
Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT.
    Lasers in surgery and medicine, 2009, Volume: 41, Issue:9

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Cardiovascular; Photobleaching; Photoche

2009
[Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
    Medicina (Kaunas, Lithuania), 2009, Volume: 45, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell

2009
The efficacy of photodynamic diagnosis in defining the lateral border between a tumor and a tumor-free area during Mohs micrographic surgery.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:11

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carci

2010
Photodynamic effects on basal cell carcinoma with topical Photosensitizer.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2010, Volume: 2010

    Topics: Administration, Topical; Carcinoma, Basal Cell; Dermatology; Humans; Monte Carlo Method; Necrosis; O

2010
Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas.
    Journal of biomedical optics, 2011, Volume: 16, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Biological; Monte Carlo Method; Phantoms

2011
In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser.
    Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:4

    Topics: Administration, Cutaneous; Aluminum; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Cell Line,

2006
Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis.
    Clinical and experimental dermatology, 2007, Volume: 32, Issue:4

    Topics: Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Facial Neoplasms; Female; Humans; Male; Middle Age

2007
Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma.
    Photochemistry and photobiology, 1994, Volume: 59, Issue:1

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Microscopy, Fluorescenc

1994
Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues.
    Cancer letters, 1997, Jan-30, Volume: 112, Issue:2

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Drug Interactions; Humans; Live

1997
An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part II. In vivo testing.
    Lasers in medical science, 2001, Volume: 16, Issue:3

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Female; Humans; Mice; Mice, Inbred BALB C; Phot

2001