protoporphyrin ix has been researched along with Carcinoma, Basal Cell in 35 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain." | 7.74 | Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. ( Cottrell, WJ; Foster, TH; Keymel, KR; Oseroff, AR; Paquette, AD, 2008) |
| "In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain." | 3.74 | Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. ( Cottrell, WJ; Foster, TH; Keymel, KR; Oseroff, AR; Paquette, AD, 2008) |
| " This method of enhancement was safely applied to a clinical PDT protocol with no unexpected adverse effects reported." | 2.73 | Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma. ( Campbell, S; Curnow, A; Pye, A, 2008) |
| "Of the 60 patients (20 Bowen's disease, 20 SCC, and 20 BCC), malignant neoplasms could be clearly distinguished from adjacent healthy tissue under fluorescence illumination (P < 0." | 1.48 | Topical application of Photofrin ( Chang, CJ; Chiang, YF; Hsiao, YC; Lin, YT, 2018) |
| " However, in the case of deep, nodular-ulcerative lesions, the complete response rates are lower, possibly related to a lower bioavailability of PpIX." | 1.35 | Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma. ( Ballini, JP; Dögnitz, N; Gabrecht, T; Lange, N; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2008) |
| "Calcitriol pretreatment of the cells elevated their PpIX levels." | 1.35 | Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells. ( Cicarma, E; Juzeniene, A; Ma, LW; Moan, J; Tuorkey, M, 2009) |
| "Ten basal cell carcinomas were coated with an ointment containing 10% ALA prior to excision; five served as controls." | 1.29 | Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. ( Landthaler, M; Sassy, T; Szeimies, RM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 14 (40.00) | 29.6817 |
| 2010's | 12 (34.29) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Stringasci, MD | 1 |
| Salvio, AG | 1 |
| Moriyama, LT | 1 |
| Vollet-Filho, JD | 1 |
| Fortunato, TC | 1 |
| Bagnato, VS | 1 |
| Kurachi, C | 1 |
| Lin, YT | 1 |
| Hsiao, YC | 1 |
| Chiang, YF | 1 |
| Chang, CJ | 1 |
| Salas-García, I | 2 |
| Fanjul-Vélez, F | 2 |
| Arce-Diego, JL | 2 |
| Salas-García, T | 1 |
| López-Gómez, A | 1 |
| Dorado-Fernández, M | 1 |
| Ruiz-Martínez, J | 1 |
| Kulyk, O | 1 |
| Ibbotson, SH | 1 |
| Moseley, H | 2 |
| Valentine, RM | 2 |
| Samuel, ID | 1 |
| El Hoshy, K | 1 |
| Bosseila, M | 1 |
| El Sharkawy, D | 1 |
| Sobhi, R | 1 |
| Cottrell, WJ | 2 |
| Paquette, AD | 1 |
| Keymel, KR | 1 |
| Foster, TH | 2 |
| Oseroff, AR | 2 |
| Dögnitz, N | 1 |
| Salomon, D | 1 |
| Zellweger, M | 1 |
| Ballini, JP | 1 |
| Gabrecht, T | 1 |
| Lange, N | 1 |
| van den Bergh, H | 1 |
| Wagnières, G | 1 |
| de Haas, ER | 2 |
| de Bruijn, HS | 1 |
| Sterenborg, HJ | 2 |
| Neumann, HA | 2 |
| Robinson, DJ | 2 |
| Cicarma, E | 1 |
| Tuorkey, M | 1 |
| Juzeniene, A | 1 |
| Ma, LW | 1 |
| Moan, J | 2 |
| Wang, KK | 1 |
| Mitra, S | 1 |
| Liutkeviciūte-Navickiene, J | 1 |
| Mordas, A | 1 |
| Simkute, S | 1 |
| Bloznelyte-Plesniene, L | 1 |
| Lee, CY | 1 |
| Kim, KH | 1 |
| Kim, YH | 1 |
| Ortega-Quijano, N | 1 |
| Brown, CT | 1 |
| Ibbotson, S | 1 |
| Wood, K | 1 |
| van der Beek, N | 1 |
| de Leeuw, J | 1 |
| Demmendal, C | 1 |
| Bjerring, P | 1 |
| Gaál, M | 1 |
| Kui, R | 1 |
| Hunyadi, Z | 1 |
| Kemény, L | 1 |
| Gyulai, R | 1 |
| Blake, E | 2 |
| Allen, J | 2 |
| Thorn, C | 1 |
| Shore, A | 1 |
| Curnow, A | 3 |
| Campbell, S | 2 |
| Mathew, J | 1 |
| Helliwell, P | 1 |
| Choudry, K | 1 |
| Brooke, RC | 1 |
| Farrar, W | 1 |
| Rhodes, LE | 1 |
| Shen, SC | 1 |
| Lee, WR | 1 |
| Fang, YP | 1 |
| Hu, CH | 1 |
| Fang, JY | 1 |
| Thompson, MS | 1 |
| Andersson-Engels, S | 4 |
| Svanberg, S | 4 |
| Johansson, T | 1 |
| Palsson, S | 1 |
| Bendsoe, N | 1 |
| Derjabo, A | 1 |
| Kapostins, J | 1 |
| Stenram, U | 1 |
| Spigulis, J | 1 |
| Svanberg, K | 4 |
| Star, WM | 1 |
| van't Veen, AJ | 1 |
| Munte, K | 1 |
| Won, Y | 1 |
| Hong, SH | 1 |
| Yu, HY | 1 |
| Kwon, YH | 1 |
| Yun, SJ | 1 |
| Lee, SC | 1 |
| Lee, JB | 1 |
| Pye, A | 1 |
| Roberts, DJ | 1 |
| Cairnduff, F | 1 |
| Szeimies, RM | 1 |
| Sassy, T | 1 |
| Landthaler, M | 1 |
| Martin, A | 2 |
| Tope, WD | 2 |
| Grevelink, JM | 1 |
| Starr, JC | 1 |
| Fewkes, JL | 1 |
| Flotte, TJ | 1 |
| Deutsch, TF | 1 |
| Anderson, RR | 2 |
| Heyerdahl, H | 1 |
| Wang, I | 3 |
| Liu, DL | 1 |
| Berg, R | 1 |
| Peng, Q | 1 |
| Ross, EV | 1 |
| Kollias, N | 1 |
| Gillies, R | 1 |
| Wennberg, AM | 1 |
| Gudmundson, F | 1 |
| Stenquist, B | 1 |
| Ternesten, A | 1 |
| Mölne, L | 1 |
| Rosén, A | 1 |
| Larko, O | 1 |
| af Klinteberg, C | 2 |
| Enejder, AM | 1 |
| Canti, G | 1 |
| Cubeddu, R | 1 |
| Eker, C | 1 |
| Pifferi, A | 1 |
| Taroni, P | 1 |
| Valentini, G | 1 |
| Fischer, F | 1 |
| Dickson, EF | 1 |
| Kennedy, JC | 2 |
| Pottier, RH | 2 |
| Pross, DC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fluorescence and Thermal Imaging of the Skin Before and During Photodynamic Therapy[NCT03167762] | 18 participants (Actual) | Interventional | 2017-06-22 | Completed | |||
| Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ[NCT03025724] | 40 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for protoporphyrin ix and Carcinoma, Basal Cell
| Article | Year |
|---|---|
Daylight photodynamic therapy.
Topics: Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Meteorological Concepts; Photochemotherapy; Photo | 2015 |
[Fluorescence diagnosis of non-melanoma skin cancer].
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous | 2012 |
Photodynamic therapy of primary skin cancer: a review.
Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents; Bowen's Disease; Carcinoma, Basal Cell; Female; Fo | 1995 |
14 trials available for protoporphyrin ix and Carcinoma, Basal Cell
| Article | Year |
|---|---|
Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Optical Imaging; Photosensit | 2015 |
PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: an intra-patient direct comparison study.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Bowen's Disease; Carcinoma; Carcinoma, Basal Cell; False Neg | 2012 |
Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Oxygen; Pho | 2013 |
The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device.
Topics: Aminolevulinic Acid; Biological Transport; Carcinoma, Basal Cell; Injections; Oxygen; Photosensitizi | 2012 |
The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5-aminolaevulinic acid photodynamic therapy.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Car | 2003 |
Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; Lasers; Male; | 2006 |
Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using two light fractions with a two-hour interval: long-term follow-up.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; M | 2006 |
Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Cell Line, Tumor; Humans; In Vi | 2008 |
Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment.
Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Male; | 1995 |
Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Basal Cell; Drug Interactions; Fluorescence; H | 1998 |
In vivo detection of basal cell carcinoma using imaging spectroscopy.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Basal Ce | 1999 |
Kinetic fluorescence studies of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in basal cell carcinomas.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; | 1999 |
Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Male; Photosensi | 2000 |
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis; Ph | 1990 |
18 other studies available for protoporphyrin ix and Carcinoma, Basal Cell
| Article | Year |
|---|---|
Energy analysis of PDT using thermography during the treatment of basal cell carcinoma.
Topics: Aged; Carcinoma, Basal Cell; Female; Humans; Male; Middle Aged; Optical Imaging; Photochemotherapy; | 2020 |
Topical application of Photofrin
Topics: Adult; Aged; Aged, 80 and over; Bowen's Disease; Carcinoma, Basal Cell; Dihematoporphyrin Ether; Fem | 2018 |
Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy.
Topics: Carcinoma, Basal Cell; Humans; Models, Biological; Photochemical Processes; Photochemotherapy; Photo | 2014 |
Can basal cell carcinoma lateral border be determined by fluorescence diagnosis?: Verification by Mohs micrographic surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Diagnostic Techniques, Surgical; Female; Fl | 2016 |
Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Huma | 2008 |
Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Dose-Response Relationship, Dru | 2008 |
Microscopic distribution of protoporphyrin (PpIX) fluorescence in superficial basal cell carcinoma during light-fractionated aminolaevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Biopsy; Carcinoma, Basal Cell; Humans; Immunohistochemistry; Ki-67 Antigen; Mic | 2008 |
Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells.
Topics: Aminolevulinic Acid; Calcitriol; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2009 |
Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Cardiovascular; Photobleaching; Photoche | 2009 |
[Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell | 2009 |
The efficacy of photodynamic diagnosis in defining the lateral border between a tumor and a tumor-free area during Mohs micrographic surgery.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carci | 2010 |
Photodynamic effects on basal cell carcinoma with topical Photosensitizer.
Topics: Administration, Topical; Carcinoma, Basal Cell; Dermatology; Humans; Monte Carlo Method; Necrosis; O | 2010 |
Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Biological; Monte Carlo Method; Phantoms | 2011 |
In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser.
Topics: Administration, Cutaneous; Aluminum; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Cell Line, | 2006 |
Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Facial Neoplasms; Female; Humans; Male; Middle Age | 2007 |
Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Microscopy, Fluorescenc | 1994 |
Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Drug Interactions; Humans; Live | 1997 |
An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part II. In vivo testing.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Female; Humans; Mice; Mice, Inbred BALB C; Phot | 2001 |