Page last updated: 2024-11-03

protoporphyrin ix and Cancer of Colon

protoporphyrin ix has been researched along with Cancer of Colon in 36 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Research Excerpts

ExcerptRelevanceReference
"BALB/c nude mice bearing WiDr human colon adenocarcinoma were used to determine the effect of ultrasound on the production of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) both in the tumors and in skin overlying the tumors."7.70Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound. ( Iani, V; Ma, L; Moan, J; Peng, Q, 1998)
"Human adenocarcinoma cells of the line WiDr and human leukemia T cells of the line Jurkat were incubated with 5-aminolevulinic acid and found to produce protoporphyrin IX (PpIX)."3.71Transfer of protoporphyrin IX between cells. ( Ma, LW; Moan, J; Stokke, T, 2002)
"Human colon adenocarcinoma cells (WiDr) and Chinese hamster lung fibroblasts cells (V79) were incubated with different concentrations of 5-aminolevulinic acid (ALA), and the production of protoporphyrin IX (PpIX) was studied using several techniques."3.70Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle. ( Bech, O; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Steen, HB; Stokke, T, 1998)
"BALB/c nude mice bearing WiDr human colon adenocarcinoma were used to determine the effect of ultrasound on the production of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) both in the tumors and in skin overlying the tumors."3.70Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound. ( Iani, V; Ma, L; Moan, J; Peng, Q, 1998)
"The response of human colon adenocarcinoma cells of the line WiDr to the combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX was assessed by a colony-forming assay."3.69Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX. ( Berg, K; Luksiene, Z; Ma, L; Moan, J, 1995)
"Chinese hamster cells (V79) and human adenocarcinoma cells (WiDr) were incubated with 5-aminolevulinic acid (ALA) at different pH values and the rate of production of protoporphyrin IX (PpIX) was measured."3.69The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid. ( Bech, O; Berg, K; Moan, J, 1997)
"Human tumor cells of the lines WiDr (adenocarcinoma of the rectosigmoid colon), NHIK 3025 (carcinoma of the cervix), and V79 Chinese hamster fibroblasts were treated with 5-aminolevulinic acid (ALA) and ALA esterified to C1-C3 and C6-C8 chained aliphatic alcohols (ALA-esters)."3.69Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture. ( Anholt, H; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Peng, Q; Selbo, PK, 1997)
"Moreover, HCT116 colon cancer cells exhibited a p53-dependent sensitivity to PpIX in a dose-dependent manner, as was demonstrated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and fluorescence-activated cell sorter (FACS) analysis of cell cycle profiles."1.34Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner. ( Hossain, S; Issaeva, N; Podhajska, AJ; Pramanik, A; Selivanova, G; Zawacka-Pankau, J, 2007)
"Protoporphyrin IX itself is a potential photosensitizer that can be used for laser light-induced fluorescence diagnosis."1.31Local 5-aminolevulinic acid application for laser light-induced fluorescence diagnosis of early staged colon cancer in rats. ( Böhm, J; Gahlen, J; Herfarth, C; Holle, R; Pressmar, J; Stern, J, 2000)
" This study compares bolus with fractionated ALA dosing in order to determine whether one of these methods results in a higher tissue concentration of PP."1.30Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo. ( Fromm, D; Herman, MA; Kessel, D; Luo, Y; Patacsil, V; Webber, J, 1997)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (44.44)18.2507
2000's13 (36.11)29.6817
2010's7 (19.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ouyang, G2
Liu, Z2
Xiong, L2
Chen, X2
Li, Q1
Huang, H2
Lin, L1
Miao, X2
Ma, L4
Chen, W2
Wen, Y2
Lam, B1
Bui, B1
Zhou, P1
Wang, K1
Zhang, Z1
Chung, CW2
Chung, KD1
Jeong, YI2
Kang, DH2
Naghavi, N2
Baygi, MH1
Sazgarnia, A3
Miranbaygi, MH1
Shanei, A1
Meibodi, NT1
Eshghi, H1
Nassirli, H1
Johnson, RP1
Suh, H1
Kim, I1
Krieg, RC2
Messmann, H4
Rauch, J1
Seeger, S2
Knuechel, R2
Moan, J8
Ma, LW4
Stokke, T4
Siboni, G1
Amit-Patito, I1
Weizman, E1
Waintraub-Porat, M1
Weitman, H1
Ehrenberg, B3
Malik, Z3
Schlottmann, K1
Endlicher, E1
Schölmerich, J2
Li, BH1
Xie, SS1
Berger, Y1
Chapuis Bernasconi, C1
Schmitt, F1
Neier, R1
Juillerat-Jeanneret, L1
Hjelde, A1
Gederaas, OA3
Krokan, HE1
Brubakk, AO1
Shahzidi, S1
Soltani, H1
Nesland, JM2
Peng, Q4
Zawacka-Pankau, J1
Issaeva, N1
Hossain, S1
Pramanik, A1
Selivanova, G1
Podhajska, AJ1
Kemmner, W1
Wan, K1
Rüttinger, S1
Ebert, B1
Macdonald, R1
Klamm, U1
Moesta, KT1
Kostenich, G2
Roitman, L2
Orenstein, A2
Mlkvy, P1
Buonaccorsi, G1
Davies, CL1
MacRobert, AJ2
Bown, SG2
Berg, K7
Luksiene, Z1
Shechtman, Y1
Kopolovic, Y1
Noodt, BB1
Anholt, H2
Bech, O3
Thorstensen, K1
Romslo, I1
Gaullier, JM2
Selbo, PK1
Geisler, M1
Gross, U1
Abels, C1
Szeimies, RM1
Steinbach, P1
Knüchel, R1
Doss, M1
Holstege, A1
Herman, MA1
Webber, J1
Luo, Y1
Patacsil, V1
Kessel, D1
Fromm, D1
Steen, HB1
Iani, V2
Rasch, MH1
Lagerberg, JW1
Dubbelman, TM1
Sesink, AL1
Termont, DS1
Kleibeuker, JH1
Van der Meer, R1
Gahlen, J2
Stern, J2
Pressmar, J1
Böhm, J1
Holle, R1
Herfarth, C2
Prosst, RL1
Pietschmann, M1
Haase, T1
Rheinwald, M1
Skopp, G1
Bedwell, J1
Phillips, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Formulation of 5-aminolevulinic Acid With Dimethylsulfoxide in Photodynamic Therapy for Treatment of Actinic Keratosis[NCT01459393]Phase 3137 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

36 other studies available for protoporphyrin ix and Cancer of Colon

ArticleYear
[Role of PpIX-based photodynamic therapy in promoting the damage and apoptosis of colorectal cancer cell and its mechanisms].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2017, Aug-28, Volume: 42, Issue:8

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Humans; Photochemotherapy; Photosensi

2017
Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 21

    Topics: Apoptosis; Autophagy; Autophagy-Related Protein 7; bcl-2-Associated X Protein; Beclin-1; Caspase 3;

2018
5-aminolevulinic acid-incorporated nanoparticles of methoxy poly(ethylene glycol)-chitosan copolymer for photodynamic therapy.
    International journal of nanomedicine, 2013, Volume: 8

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Humans; Nanoparti

2013
Determination of time-dependent protoporphyrin IX concentration for photodynamic therapy dosimetry in a mice colon tumor model using fluorescence spectroscopy.
    Applied spectroscopy, 2010, Volume: 64, Issue:12

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Female; Kinetics; Male; Mice; Mic

2010
Simulation of fractionated and continuous irradiation in photodynamic therapy: study the differences between photobleaching and singlet oxygen dose deposition.
    Australasian physical & engineering sciences in medicine, 2011, Volume: 34, Issue:2

    Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Computer Simulation; Mice; Mice, Inbred BALB C; Mod

2011
A novel nanosonosensitizer for sonodynamic therapy: in vivo study on a colon tumor model.
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2011, Volume: 30, Issue:10

    Topics: Analysis of Variance; Animals; Cell Line, Tumor; Colonic Neoplasms; Gold; Mice; Mice, Inbred BALB C;

2011
Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; Colonic Neoplasms; Flow Cytometry; HCT116 Cells; HEK2

2012
Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship

2002
Transfer of protoporphyrin IX between cells.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Colonic Neoplasms; Humans

2002
Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.
    Cancer letters, 2003, Jun-30, Volume: 196, Issue:1

    Topics: Animals; Anthracenes; Butyrates; Carcinoma; Cell Cycle; Cell Differentiation; Colonic Neoplasms; Mic

2003
Intracellular localization is a cofactor for the phototoxicity of protoporphyrin IX in the gastrointestinal tract: in vitro study.
    Photochemistry and photobiology, 2003, Volume: 78, Issue:4

    Topics: Adenocarcinoma; Colonic Neoplasms; Digestive System; Humans; Photochemotherapy; Photosensitizing Age

2003
Autofluorescence excitation-emission matrices for diagnosis of colonic cancer.
    World journal of gastroenterology, 2005, Jul-07, Volume: 11, Issue:25

    Topics: Amino Acids; Case-Control Studies; Colonic Neoplasms; Flavin-Adenine Dinucleotide; Fluorescence; Hum

2005
Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system.
    Chemistry & biology, 2005, Volume: 12, Issue:8

    Topics: Adenosine Deaminase; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cys

2005
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:10

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hyperoxia; Lipid Peroxida

2005
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Su

2006
Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner.
    The Journal of biological chemistry, 2007, Jan-26, Volume: 282, Issue:4

    Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Cell Death; Ce

2007
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:2

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation

2008
Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
    Journal of photochemistry and photobiology. B, Biology, 1995, Volume: 28, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Colonic Neoplasms; Dimethyl Sulfoxide; Edetic

1995
Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies.
    British journal of cancer, 1995, Volume: 72, Issue:3

    Topics: Aminolevulinic Acid; Animals; Colon; Colonic Neoplasms; Female; Light; Maximum Allowable Concentrati

1995
Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX.
    Radiation research, 1995, Volume: 142, Issue:3

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colonic Ne

1995
A comparative study of tissue distribution and photodynamic therapy selectivity of chlorin e6, Photofrin II and ALA-induced protoporphyrin IX in a colon carcinoma model.
    British journal of cancer, 1996, Volume: 73, Issue:8

    Topics: Aminolevulinic Acid; Animals; Chlorophyllides; Colonic Neoplasms; Dihematoporphyrin Ether; Female; F

1996
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
    British journal of cancer, 1996, Volume: 74, Issue:1

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cells, Cultured; Colonic Neoplasms; Criceti

1996
The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells.
    British journal of cancer, 1996, Volume: 74, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Dicarbethox

1996
The effect of brief illumination on intracellular free calcium concentration in cells with 5-aminolevulinic acid-induced protoporphyrin IX synthesis.
    Scandinavian journal of clinical and laboratory investigation, 1996, Volume: 56, Issue:7

    Topics: Adenocarcinoma; Aminolevulinic Acid; Calcium; Colonic Neoplasms; Cytosol; DNA; Egtazic Acid; Fluores

1996
The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid.
    Cancer letters, 1997, Feb-26, Volume: 113, Issue:1-2

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Survival; Colonic Neoplasms; Cricetinae; Fibrobla

1997
Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.
    Cancer research, 1997, Apr-15, Volume: 57, Issue:8

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Drug Screen

1997
Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.
    British journal of cancer, 1997, Volume: 76, Issue:7

    Topics: Aminolevulinic Acid; Carcinoma; Colonic Neoplasms; Hematoporphyrins; Humans; Photochemotherapy; Phot

1997
Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:2

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Mice; Photosensitizi

1997
Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle.
    International journal of cancer, 1998, Jan-05, Volume: 75, Issue:1

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Communication; Cell Count; Cell Cycle; Cell Line;

1998
Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound.
    International journal of cancer, 1998, Nov-09, Volume: 78, Issue:4

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Humans; Mice; Mice, Inbred

1998
Photodynamically induced effects in colon carcinoma cells (WiDr) by endogenous photosensitizers generated by incubation with 5-aminolaevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 1999, Volume: 49, Issue:2-3

    Topics: Adenosine Triphosphate; Aminolevulinic Acid; Biomarkers, Tumor; Colonic Neoplasms; Fluorescent Dyes;

1999
Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
    Cancer research, 1999, Nov-15, Volume: 59, Issue:22

    Topics: Animals; Bilirubin; Cell Division; Colon; Colonic Neoplasms; Feces; Ferric Compounds; Heme; Hemin; I

1999
Local 5-aminolevulinic acid application for laser light-induced fluorescence diagnosis of early staged colon cancer in rats.
    Lasers in surgery and medicine, 2000, Volume: 26, Issue:3

    Topics: 1,2-Dimethylhydrazine; Aminolevulinic Acid; Animals; Biomarkers, Tumor; Colon; Colonic Neoplasms; Co

2000
On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters.
    International journal of cancer, 2001, Apr-01, Volume: 92, Issue:1

    Topics: Adenocarcinoma; Administration, Cutaneous; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female;

2001
Laparoscopic fluorescence diagnosis for intraabdominal fluorescence targeting of peritoneal carcinosis experimental studies.
    Annals of surgery, 2002, Volume: 235, Issue:2

    Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Fluorescence; Laparoscopy; Neoplasm Staging; Perito

2002
Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.
    British journal of cancer, 1992, Volume: 65, Issue:6

    Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Intestinal Mucosa; Microscopy, Fluorescence; Neopla

1992