protoporphyrin ix has been researched along with Cancer of Colon in 36 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "BALB/c nude mice bearing WiDr human colon adenocarcinoma were used to determine the effect of ultrasound on the production of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) both in the tumors and in skin overlying the tumors." | 7.70 | Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound. ( Iani, V; Ma, L; Moan, J; Peng, Q, 1998) |
| "Human adenocarcinoma cells of the line WiDr and human leukemia T cells of the line Jurkat were incubated with 5-aminolevulinic acid and found to produce protoporphyrin IX (PpIX)." | 3.71 | Transfer of protoporphyrin IX between cells. ( Ma, LW; Moan, J; Stokke, T, 2002) |
| "Human colon adenocarcinoma cells (WiDr) and Chinese hamster lung fibroblasts cells (V79) were incubated with different concentrations of 5-aminolevulinic acid (ALA), and the production of protoporphyrin IX (PpIX) was studied using several techniques." | 3.70 | Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle. ( Bech, O; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Steen, HB; Stokke, T, 1998) |
| "BALB/c nude mice bearing WiDr human colon adenocarcinoma were used to determine the effect of ultrasound on the production of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) both in the tumors and in skin overlying the tumors." | 3.70 | Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound. ( Iani, V; Ma, L; Moan, J; Peng, Q, 1998) |
| "The response of human colon adenocarcinoma cells of the line WiDr to the combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX was assessed by a colony-forming assay." | 3.69 | Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX. ( Berg, K; Luksiene, Z; Ma, L; Moan, J, 1995) |
| "Chinese hamster cells (V79) and human adenocarcinoma cells (WiDr) were incubated with 5-aminolevulinic acid (ALA) at different pH values and the rate of production of protoporphyrin IX (PpIX) was measured." | 3.69 | The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid. ( Bech, O; Berg, K; Moan, J, 1997) |
| "Human tumor cells of the lines WiDr (adenocarcinoma of the rectosigmoid colon), NHIK 3025 (carcinoma of the cervix), and V79 Chinese hamster fibroblasts were treated with 5-aminolevulinic acid (ALA) and ALA esterified to C1-C3 and C6-C8 chained aliphatic alcohols (ALA-esters)." | 3.69 | Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture. ( Anholt, H; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Peng, Q; Selbo, PK, 1997) |
| "Moreover, HCT116 colon cancer cells exhibited a p53-dependent sensitivity to PpIX in a dose-dependent manner, as was demonstrated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and fluorescence-activated cell sorter (FACS) analysis of cell cycle profiles." | 1.34 | Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner. ( Hossain, S; Issaeva, N; Podhajska, AJ; Pramanik, A; Selivanova, G; Zawacka-Pankau, J, 2007) |
| "Protoporphyrin IX itself is a potential photosensitizer that can be used for laser light-induced fluorescence diagnosis." | 1.31 | Local 5-aminolevulinic acid application for laser light-induced fluorescence diagnosis of early staged colon cancer in rats. ( Böhm, J; Gahlen, J; Herfarth, C; Holle, R; Pressmar, J; Stern, J, 2000) |
| " This study compares bolus with fractionated ALA dosing in order to determine whether one of these methods results in a higher tissue concentration of PP." | 1.30 | Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo. ( Fromm, D; Herman, MA; Kessel, D; Luo, Y; Patacsil, V; Webber, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (44.44) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 7 (19.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ouyang, G | 2 |
| Liu, Z | 2 |
| Xiong, L | 2 |
| Chen, X | 2 |
| Li, Q | 1 |
| Huang, H | 2 |
| Lin, L | 1 |
| Miao, X | 2 |
| Ma, L | 4 |
| Chen, W | 2 |
| Wen, Y | 2 |
| Lam, B | 1 |
| Bui, B | 1 |
| Zhou, P | 1 |
| Wang, K | 1 |
| Zhang, Z | 1 |
| Chung, CW | 2 |
| Chung, KD | 1 |
| Jeong, YI | 2 |
| Kang, DH | 2 |
| Naghavi, N | 2 |
| Baygi, MH | 1 |
| Sazgarnia, A | 3 |
| Miranbaygi, MH | 1 |
| Shanei, A | 1 |
| Meibodi, NT | 1 |
| Eshghi, H | 1 |
| Nassirli, H | 1 |
| Johnson, RP | 1 |
| Suh, H | 1 |
| Kim, I | 1 |
| Krieg, RC | 2 |
| Messmann, H | 4 |
| Rauch, J | 1 |
| Seeger, S | 2 |
| Knuechel, R | 2 |
| Moan, J | 8 |
| Ma, LW | 4 |
| Stokke, T | 4 |
| Siboni, G | 1 |
| Amit-Patito, I | 1 |
| Weizman, E | 1 |
| Waintraub-Porat, M | 1 |
| Weitman, H | 1 |
| Ehrenberg, B | 3 |
| Malik, Z | 3 |
| Schlottmann, K | 1 |
| Endlicher, E | 1 |
| Schölmerich, J | 2 |
| Li, BH | 1 |
| Xie, SS | 1 |
| Berger, Y | 1 |
| Chapuis Bernasconi, C | 1 |
| Schmitt, F | 1 |
| Neier, R | 1 |
| Juillerat-Jeanneret, L | 1 |
| Hjelde, A | 1 |
| Gederaas, OA | 3 |
| Krokan, HE | 1 |
| Brubakk, AO | 1 |
| Shahzidi, S | 1 |
| Soltani, H | 1 |
| Nesland, JM | 2 |
| Peng, Q | 4 |
| Zawacka-Pankau, J | 1 |
| Issaeva, N | 1 |
| Hossain, S | 1 |
| Pramanik, A | 1 |
| Selivanova, G | 1 |
| Podhajska, AJ | 1 |
| Kemmner, W | 1 |
| Wan, K | 1 |
| Rüttinger, S | 1 |
| Ebert, B | 1 |
| Macdonald, R | 1 |
| Klamm, U | 1 |
| Moesta, KT | 1 |
| Kostenich, G | 2 |
| Roitman, L | 2 |
| Orenstein, A | 2 |
| Mlkvy, P | 1 |
| Buonaccorsi, G | 1 |
| Davies, CL | 1 |
| MacRobert, AJ | 2 |
| Bown, SG | 2 |
| Berg, K | 7 |
| Luksiene, Z | 1 |
| Shechtman, Y | 1 |
| Kopolovic, Y | 1 |
| Noodt, BB | 1 |
| Anholt, H | 2 |
| Bech, O | 3 |
| Thorstensen, K | 1 |
| Romslo, I | 1 |
| Gaullier, JM | 2 |
| Selbo, PK | 1 |
| Geisler, M | 1 |
| Gross, U | 1 |
| Abels, C | 1 |
| Szeimies, RM | 1 |
| Steinbach, P | 1 |
| Knüchel, R | 1 |
| Doss, M | 1 |
| Holstege, A | 1 |
| Herman, MA | 1 |
| Webber, J | 1 |
| Luo, Y | 1 |
| Patacsil, V | 1 |
| Kessel, D | 1 |
| Fromm, D | 1 |
| Steen, HB | 1 |
| Iani, V | 2 |
| Rasch, MH | 1 |
| Lagerberg, JW | 1 |
| Dubbelman, TM | 1 |
| Sesink, AL | 1 |
| Termont, DS | 1 |
| Kleibeuker, JH | 1 |
| Van der Meer, R | 1 |
| Gahlen, J | 2 |
| Stern, J | 2 |
| Pressmar, J | 1 |
| Böhm, J | 1 |
| Holle, R | 1 |
| Herfarth, C | 2 |
| Prosst, RL | 1 |
| Pietschmann, M | 1 |
| Haase, T | 1 |
| Rheinwald, M | 1 |
| Skopp, G | 1 |
| Bedwell, J | 1 |
| Phillips, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Formulation of 5-aminolevulinic Acid With Dimethylsulfoxide in Photodynamic Therapy for Treatment of Actinic Keratosis[NCT01459393] | Phase 3 | 137 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
36 other studies available for protoporphyrin ix and Cancer of Colon
| Article | Year |
|---|---|
[Role of PpIX-based photodynamic therapy in promoting the damage and apoptosis of colorectal cancer cell and its mechanisms].
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Humans; Photochemotherapy; Photosensi | 2017 |
Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells.
Topics: Apoptosis; Autophagy; Autophagy-Related Protein 7; bcl-2-Associated X Protein; Beclin-1; Caspase 3; | 2018 |
5-aminolevulinic acid-incorporated nanoparticles of methoxy poly(ethylene glycol)-chitosan copolymer for photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Humans; Nanoparti | 2013 |
Determination of time-dependent protoporphyrin IX concentration for photodynamic therapy dosimetry in a mice colon tumor model using fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Female; Kinetics; Male; Mice; Mic | 2010 |
Simulation of fractionated and continuous irradiation in photodynamic therapy: study the differences between photobleaching and singlet oxygen dose deposition.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Computer Simulation; Mice; Mice, Inbred BALB C; Mod | 2011 |
A novel nanosonosensitizer for sonodynamic therapy: in vivo study on a colon tumor model.
Topics: Analysis of Variance; Animals; Cell Line, Tumor; Colonic Neoplasms; Gold; Mice; Mice, Inbred BALB C; | 2011 |
Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy.
Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; Colonic Neoplasms; Flow Cytometry; HCT116 Cells; HEK2 | 2012 |
Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship | 2002 |
Transfer of protoporphyrin IX between cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Colonic Neoplasms; Humans | 2002 |
Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.
Topics: Animals; Anthracenes; Butyrates; Carcinoma; Cell Cycle; Cell Differentiation; Colonic Neoplasms; Mic | 2003 |
Intracellular localization is a cofactor for the phototoxicity of protoporphyrin IX in the gastrointestinal tract: in vitro study.
Topics: Adenocarcinoma; Colonic Neoplasms; Digestive System; Humans; Photochemotherapy; Photosensitizing Age | 2003 |
Autofluorescence excitation-emission matrices for diagnosis of colonic cancer.
Topics: Amino Acids; Case-Control Studies; Colonic Neoplasms; Flavin-Adenine Dinucleotide; Fluorescence; Hum | 2005 |
Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system.
Topics: Adenosine Deaminase; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cys | 2005 |
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hyperoxia; Lipid Peroxida | 2005 |
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Su | 2006 |
Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Cell Death; Ce | 2007 |
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation | 2008 |
Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Colonic Neoplasms; Dimethyl Sulfoxide; Edetic | 1995 |
Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies.
Topics: Aminolevulinic Acid; Animals; Colon; Colonic Neoplasms; Female; Light; Maximum Allowable Concentrati | 1995 |
Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colonic Ne | 1995 |
A comparative study of tissue distribution and photodynamic therapy selectivity of chlorin e6, Photofrin II and ALA-induced protoporphyrin IX in a colon carcinoma model.
Topics: Aminolevulinic Acid; Animals; Chlorophyllides; Colonic Neoplasms; Dihematoporphyrin Ether; Female; F | 1996 |
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cells, Cultured; Colonic Neoplasms; Criceti | 1996 |
The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Dicarbethox | 1996 |
The effect of brief illumination on intracellular free calcium concentration in cells with 5-aminolevulinic acid-induced protoporphyrin IX synthesis.
Topics: Adenocarcinoma; Aminolevulinic Acid; Calcium; Colonic Neoplasms; Cytosol; DNA; Egtazic Acid; Fluores | 1996 |
The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Survival; Colonic Neoplasms; Cricetinae; Fibrobla | 1997 |
Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Drug Screen | 1997 |
Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.
Topics: Aminolevulinic Acid; Carcinoma; Colonic Neoplasms; Hematoporphyrins; Humans; Photochemotherapy; Phot | 1997 |
Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Mice; Photosensitizi | 1997 |
Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Communication; Cell Count; Cell Cycle; Cell Line; | 1998 |
Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Humans; Mice; Mice, Inbred | 1998 |
Photodynamically induced effects in colon carcinoma cells (WiDr) by endogenous photosensitizers generated by incubation with 5-aminolaevulinic acid.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Biomarkers, Tumor; Colonic Neoplasms; Fluorescent Dyes; | 1999 |
Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
Topics: Animals; Bilirubin; Cell Division; Colon; Colonic Neoplasms; Feces; Ferric Compounds; Heme; Hemin; I | 1999 |
Local 5-aminolevulinic acid application for laser light-induced fluorescence diagnosis of early staged colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Aminolevulinic Acid; Animals; Biomarkers, Tumor; Colon; Colonic Neoplasms; Co | 2000 |
On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters.
Topics: Adenocarcinoma; Administration, Cutaneous; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; | 2001 |
Laparoscopic fluorescence diagnosis for intraabdominal fluorescence targeting of peritoneal carcinosis experimental studies.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Fluorescence; Laparoscopy; Neoplasm Staging; Perito | 2002 |
Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Intestinal Mucosa; Microscopy, Fluorescence; Neopla | 1992 |