protoporphyrin ix has been researched along with Breast Cancer in 28 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)." | 7.88 | Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018) |
| "Protoporphyrin IX (PpIX) is an effective hematoporphyrin derivative, widely adopted in photodynamic therapy (PDT) and sonodynamic therapy (SDT)." | 5.40 | Comparison of protoporphyrin IX produced cell proliferation inhibition between human breast cancer MCF-7 and MDA-MB-231 cells. ( Chen, Y; Feng, X; Li, L; Liu, Q; Wang, P; Wang, X, 2014) |
| " This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)." | 3.88 | Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018) |
| "A photodynamic technique for human breast cancer detection founded upon the ability of tumour cells to rapidly accumulate the fluorescent product protoporphyrin IX (PpIX) has been applied to transgenic mouse models of mammary tumorigenesis." | 3.73 | Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation. ( Beamer, WG; Dorward, AM; Duffy, TM; Fancher, KS; Walt, H, 2005) |
| "Aminolevulinic acid (ALA) is a prodrug that is metabolized in the heme biosynthesis pathway to produce protoporphyrin IX (PpIX) for tumor fluorescence detection and photodynamic therapy (PDT)." | 1.51 | Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid-mediated Protoporphyrin IX by Iron Chelator Deferoxamine. ( Braun, A; Chen, B; Howley, R; Kraus, D; Mansi, M; Myers, KA; Palasuberniam, P, 2019) |
| "Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light." | 1.48 | Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy. ( Arellano, DL; Chauhan, K; Fournier, PGJ; Hirata, GA; Jain, A; Juárez, P; Sengar, P; Verdugo-Meza, A, 2018) |
| "Here, we report that breast cancer nodules in mice can be effectively treated by preconditioning the tumors with 1α, 25-dihydroxyvitamin D3 (calcitriol; Vit D) prior to administering 5-aminolevulinate (ALA)-based PDT." | 1.42 | Vitamin D enhances the efficacy of photodynamic therapy in a murine model of breast cancer. ( Anand, S; Maytin, EV; Rollakanti, KR, 2015) |
| "Protoporphyrin IX (PpIX) is an effective hematoporphyrin derivative, widely adopted in photodynamic therapy (PDT) and sonodynamic therapy (SDT)." | 1.40 | Comparison of protoporphyrin IX produced cell proliferation inhibition between human breast cancer MCF-7 and MDA-MB-231 cells. ( Chen, Y; Feng, X; Li, L; Liu, Q; Wang, P; Wang, X, 2014) |
| "The prostate and breast cancer cell lines were investigated: MCF-7, a human breast cancer responsive to androgen therapy; MDA-MB231, a more aggressive human breast cancer non-responsive to androgen therapy; LNCaP, a lymphonodal metastasis of prostate carcinoma responsive to androgen therapy; DU-145, a human prostate cancer non-responsive to androgen therapy." | 1.37 | Inhibition of cell growth induced by photosensitizer PP(Arg)2-mediated photodynamic therapy in human breast and prostate cell lines. Part I. ( Małecki, M; Nowak-Stępniowska, A; Padzik-Graczyk, A; Romiszewska, A; Wiktorska, K, 2011) |
| "Multi-drug resistance of breast cancer is a major obstacle in chemotherapy of cancer treatments." | 1.37 | Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug. ( Berkovitch-Luria, G; Feuerstein, T; Malik, Z; Nudelman, A; Rephaeli, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 17 (60.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Chudal, L | 1 |
| Pandey, NK | 1 |
| Phan, J | 1 |
| Johnson, O | 1 |
| Li, X | 1 |
| Chen, W | 1 |
| Huang, Z | 1 |
| Wei, G | 1 |
| Zeng, Z | 1 |
| Huang, Y | 1 |
| Huang, L | 1 |
| Shen, Y | 1 |
| Sun, X | 1 |
| Xu, C | 1 |
| Zhao, C | 1 |
| Liu, J | 1 |
| Qing, X | 1 |
| Zhang, Q | 1 |
| Yu, N | 1 |
| Ding, M | 1 |
| Li, Z | 1 |
| Zhao, Z | 1 |
| Zhou, Z | 1 |
| Li, J | 1 |
| Abo-Zeid, MAM | 1 |
| Abo-Elfadl, MT | 1 |
| Mostafa, SM | 1 |
| Sengar, P | 1 |
| Juárez, P | 1 |
| Verdugo-Meza, A | 1 |
| Arellano, DL | 1 |
| Jain, A | 1 |
| Chauhan, K | 1 |
| Hirata, GA | 1 |
| Fournier, PGJ | 1 |
| Wang, Y | 1 |
| Yang, M | 1 |
| Qian, J | 1 |
| Xu, W | 1 |
| Wang, J | 1 |
| Hou, G | 1 |
| Ji, L | 1 |
| Suo, A | 1 |
| Gharibi, N | 1 |
| Kailass, K | 1 |
| Beharry, AA | 1 |
| Palasuberniam, P | 2 |
| Kraus, D | 1 |
| Mansi, M | 1 |
| Braun, A | 1 |
| Howley, R | 1 |
| Myers, KA | 2 |
| Chen, B | 2 |
| Morita, M | 1 |
| Tanaka, H | 1 |
| Kumamoto, Y | 1 |
| Nakamura, A | 1 |
| Harada, Y | 1 |
| Ogata, T | 1 |
| Sakaguchi, K | 1 |
| Taguchi, T | 1 |
| Takamatsu, T | 1 |
| Li, L | 1 |
| Chen, Y | 1 |
| Wang, X | 2 |
| Feng, X | 1 |
| Wang, P | 2 |
| Liu, Q | 2 |
| Rollakanti, KR | 1 |
| Anand, S | 1 |
| Maytin, EV | 1 |
| Yang, X | 1 |
| Wang, C | 1 |
| Fahey, JM | 1 |
| Girotti, AW | 4 |
| Misiewicz-Krzemińska, I | 1 |
| Skupińska, K | 1 |
| Graczyk, A | 1 |
| Kasprzycka-Guttman, T | 1 |
| Bhowmick, R | 1 |
| Nowak-Stępniowska, A | 2 |
| Małecki, M | 2 |
| Wiktorska, K | 2 |
| Romiszewska, A | 1 |
| Padzik-Graczyk, A | 2 |
| Feuerstein, T | 1 |
| Berkovitch-Luria, G | 1 |
| Nudelman, A | 1 |
| Rephaeli, A | 1 |
| Malik, Z | 1 |
| Ziegler, VG | 1 |
| Knaup, J | 1 |
| Stahl, D | 1 |
| Krammer, B | 1 |
| Plaetzer, K | 1 |
| Li, Y | 1 |
| Zhao, P | 1 |
| Zhu, S | 1 |
| Milczarek, M | 1 |
| Lubelska, K | 1 |
| Kriska, T | 1 |
| Korytowski, W | 2 |
| Rahimipour, S | 1 |
| Ben-Aroya, N | 1 |
| Ziv, K | 1 |
| Chen, A | 1 |
| Fridkin, M | 1 |
| Koch, Y | 1 |
| Sabban, F | 1 |
| Collinet, P | 1 |
| Cosson, M | 1 |
| Mordon, S | 1 |
| Berger, Y | 1 |
| Chapuis Bernasconi, C | 1 |
| Schmitt, F | 1 |
| Neier, R | 1 |
| Juillerat-Jeanneret, L | 1 |
| Dorward, AM | 1 |
| Fancher, KS | 1 |
| Duffy, TM | 1 |
| Beamer, WG | 1 |
| Walt, H | 1 |
| Niziolek, M | 1 |
| Alvarez, MG | 1 |
| Lacelli, MS | 1 |
| Rivarola, V | 1 |
| Batlle, A | 1 |
| Fukuda, H | 1 |
| Hilf, R | 1 |
| Havens, JJ | 1 |
| Gibson, SL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study[NCT06052033] | 40 participants (Anticipated) | Interventional | 2023-09-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for protoporphyrin ix and Breast Cancer
| Article | Year |
|---|---|
[Fluorescence imaging technique: diagnostic and therapeutic interest in gynecology].
Topics: Aminolevulinic Acid; Breast Neoplasms; Female; Genital Diseases, Female; Gynecology; Humans; Neoplas | 2004 |
27 other studies available for protoporphyrin ix and Breast Cancer
| Article | Year |
|---|---|
Investigation of PPIX-Lipo-MnO
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydrogen Peroxide; Liposo | 2019 |
Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Humans; Imidazoles; Indoleamine | 2019 |
Oxygen-producing proenzyme hydrogels for photodynamic-mediated metastasis-inhibiting combinational therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; D | 2021 |
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines.
Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Hepatocellular; DNA Damage; Hep G2 | 2018 |
Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Folic Acid; Luminescent Agents; Male; Mice; Nan | 2018 |
Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Chitosan; Doxorubi | 2019 |
Exploiting the Cellular Redox-Control System for Activatable Photodynamic Therapy.
Topics: A549 Cells; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Survival; Drug Screeni | 2019 |
Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid-mediated Protoporphyrin IX by Iron Chelator Deferoxamine.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Deferoxamine; Epithelial Cells; Female; Fer | 2019 |
Fluorescence-based discrimination of breast cancer cells by direct exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Biopsy, Fine-Needle; Breast Neoplasms; Cell Line, Tumor; Diketopiperaz | 2019 |
Comparison of protoporphyrin IX produced cell proliferation inhibition between human breast cancer MCF-7 and MDA-MB-231 cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Surviv | 2014 |
Vitamin D enhances the efficacy of photodynamic therapy in a murine model of breast cancer.
Topics: Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; | 2015 |
Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplas | 2016 |
Nitric oxide-mediated resistance to photodynamic therapy in a human breast tumor xenograft model: Improved outcome with NOS2 inhibitors.
Topics: Amidines; Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzoates; Benzyla | 2017 |
Influence of protoporphyrin IX amino acid substituents on affinity to human breast adenocarcinoma MCF-7 cells.
Topics: Amino Acids, Diamino; Arginine; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Histocyto | 2009 |
Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide.
Topics: Aminolevulinic Acid; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; | 2009 |
Inhibition of cell growth induced by photosensitizer PP(Arg)2-mediated photodynamic therapy in human breast and prostate cell lines. Part I.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Hu | 2011 |
Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Dru | 2011 |
Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Endothe | 2011 |
Apoptosis induced by sonodynamic treatment by protoporphyrin IX on MDA-MB-231 cells.
Topics: Acetylcysteine; Adenosine Diphosphate Ribose; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cel | 2012 |
Cytotoxicity of PP(Arg)2- and PP(Ala)2(Arg)2-based photodynamic therapy and early stage of apoptosis induction in human breast cancers in vitro.
Topics: Amino Acids, Diamino; Apoptosis; Breast Neoplasms; Female; Humans; Mitochondria; Photochemotherapy; | 2012 |
Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Flow Cytometry; Free Radicals; Glut | 2002 |
Receptor-mediated targeting of a photosensitizer by its conjugation to gonadotropin-releasing hormone analogues.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Breast Neoplasms; Cell Line; Cell Survival; Estr | 2003 |
Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system.
Topics: Adenosine Deaminase; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cys | 2005 |
Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation.
Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Protopo | 2005 |
Nitric oxide-induced resistance to lethal photooxidative damage in a breast tumor cell line.
Topics: Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Ferritins; Heme | 2006 |
5-aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; D | 2007 |
Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA.
Topics: Aminolevulinic Acid; Breast Neoplasms; DNA; Gene Expression Regulation, Neoplastic; Humans; Hydroxym | 1999 |