protoporphyrin ix has been researched along with Benign Neoplasms, Brain in 106 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented." | 9.24 | A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 9.05 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| "5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas." | 8.12 | Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022) |
| "5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection." | 8.12 | Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022) |
| "This study investigated the degree of tumor cell infiltration in the tumor cavity and ventricle wall based on fluorescent signals of 5-aminolevulinic acid (5-ALA) after removal of the magnetic resonance (MR)-enhancing area and analyzed its prognostic significance in glioblastoma." | 8.02 | Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma. ( Jang, W-; Jung, S; Jung, T-; Kim, I-; Kim, J-; Kim, S-; Lee, K-; Moon, K-, 2021) |
| "Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors." | 7.91 | Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019) |
| "Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration." | 7.91 | Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019) |
| "5-Aminolevulinic acid-induced PpIX fluorescence was assessed in GL261-Luc2 cells in vitro and in vivo after implantation in mouse brains, at an invading glioma growth stage, simulating residual tumor." | 7.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas." | 7.88 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 7.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment." | 7.85 | Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma. ( Cho, HR; Choi, A; Choi, H; Choi, SH; Chowdhury, T; Dho, YS; Hwang, T; Kim, DG; Kim, H; Kim, HC; Kim, JE; Kim, JI; Kim, JW; Kim, S; Kim, SK; Kim, YH; Lee, SH; Park, CK; Park, S; Park, SH; Seo, Y; Shin, JY; Xu, WJ, 2017) |
| "5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker." | 7.85 | 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017) |
| "Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival." | 7.81 | Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015) |
| "We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells." | 7.80 | [Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014) |
| "In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas." | 7.78 | Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| "These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas." | 7.78 | ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012) |
| "The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated." | 7.74 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "Malignant gliomas are locally invasive tumors that offer a poor prognosis." | 6.53 | Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016) |
| "This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy." | 5.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor." | 5.32 | Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003) |
| "OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination." | 5.27 | Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018) |
| "The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented." | 5.24 | A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017) |
| "Interstitial photodynamic therapy (iPDT) of non-resectable recurrent glioblastoma using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has shown a promising outcome." | 5.17 | Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis. ( Beyer, W; Egensperger, R; Faber, F; Johansson, A; Kniebühler, G; Kreth, FW; Sroka, R; Stepp, H, 2013) |
| " Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)." | 5.15 | Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011) |
| "Oral application of 20 mg/kg body weight of 5-aminolevulinic acid (ALA) leads to a highly specific accumulation of fluorescent Protoporphyrin IX (PPIX) in malignant glioma tissue." | 5.12 | ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. ( Beck, T; Kreth, FW; Meinel, T; Pongratz, T; Stepp, H; Stummer, W; Tonn, JCh, 2007) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 5.05 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| "The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade." | 4.88 | Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. ( Colditz, MJ; Jeffree, RL; Leyen, Kv, 2012) |
| "Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas." | 4.85 | [Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009) |
| "5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas." | 4.12 | Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022) |
| "5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection." | 4.12 | Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022) |
| "This study evaluated the use of molecular imaging of fluorescent glucose analog 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) as a discriminatory marker for intraoperative tumor border identification in a murine glioma model." | 4.02 | Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. ( Bardonova, L; Belykh, E; Eschbacher, JM; George, LL; Georges, JF; Healey, DR; Jubran, JH; Mehta, S; Nakaji, P; Preul, MC; Quarles, CC; Scheck, AC, 2021) |
| "This study investigated the degree of tumor cell infiltration in the tumor cavity and ventricle wall based on fluorescent signals of 5-aminolevulinic acid (5-ALA) after removal of the magnetic resonance (MR)-enhancing area and analyzed its prognostic significance in glioblastoma." | 4.02 | Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma. ( Jang, W-; Jung, S; Jung, T-; Kim, I-; Kim, J-; Kim, S-; Lee, K-; Moon, K-, 2021) |
| "Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration." | 3.91 | Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019) |
| "Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors." | 3.91 | Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019) |
| "5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients' outcome." | 3.91 | Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors. ( Brentrup, A; Kaneko, S; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W; Suero Molina, E, 2019) |
| "5-Aminolevulinic acid-induced PpIX fluorescence was assessed in GL261-Luc2 cells in vitro and in vivo after implantation in mouse brains, at an invading glioma growth stage, simulating residual tumor." | 3.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas." | 3.88 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas." | 3.88 | Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching. ( Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K, 2018) |
| "Mapping the optical absorption and scattering properties of tissues using spatial frequency-domain imaging (SFDI) enhances quantitative fluorescence imaging of protoporphyrin IX (PpIX) in gliomas in the preclinical setting." | 3.88 | Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection. ( Olson, J; Paulsen, K; Roberts, DW; Sibai, M; Wilson, BC; Wirth, D, 2018) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 3.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "Fluorescence guided surgery (FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual contrast between normal and malignant tissue during resection of high grade gliomas." | 3.85 | Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors. ( Bravo, JJ; Davis, SC; Kanick, SC; Olson, JD; Paulsen, KD; Roberts, DW, 2017) |
| "Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment." | 3.85 | Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma. ( Cho, HR; Choi, A; Choi, H; Choi, SH; Chowdhury, T; Dho, YS; Hwang, T; Kim, DG; Kim, H; Kim, HC; Kim, JE; Kim, JI; Kim, JW; Kim, S; Kim, SK; Kim, YH; Lee, SH; Park, CK; Park, S; Park, SH; Seo, Y; Shin, JY; Xu, WJ, 2017) |
| "5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker." | 3.85 | 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017) |
| " The prodrugs display reduced acute toxicity compared to 5-ALA-Hex with superior dose response profiles of protoporphyrin IX synthesis and fluorescence intensity in human glioblastoma cells in vitro." | 3.83 | Tunable phosphatase-sensitive stable prodrugs of 5-aminolevulinic acid for tumor fluorescence photodetection. ( Allémann, E; Ateb, I; Babič, A; Herceg, V; Lange, N, 2016) |
| "Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival." | 3.81 | Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015) |
| "We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells." | 3.80 | [Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014) |
| "Good quality protoporphyrin IX fluorescence was acquired using the surgical loupe system during glioblastoma resection, which was nearly identical to that acquired by fluorescent microscopy." | 3.79 | A surgical loupe system for observing protoporphyrin IX fluorescence in high-grade gliomas after administering 5-aminolevulinic acid. ( Furuse, M; Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2013) |
| "These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas." | 3.78 | ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012) |
| "In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas." | 3.78 | Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| " Experiments with protoporphyrin IX in a glioma rodent model demonstrate in vivo quantitative and spectrally-resolved fluorescence imaging of infiltrating tumor margins for the first time." | 3.78 | Quantitative, spectrally-resolved intraoperative fluorescence imaging. ( Jacobs, VL; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| " In recent clinical studies, fluorescence monitoring during iPDT of glioblastoma multiforme has revealed patient-specific accumulation of photosensitizer (aminolevulinic acid (ALA) induced protoporphyrin IX, PpIX) and its photobleaching kinetics." | 3.77 | Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy. ( Hennig, G; Johansson, A; Stepp, H, 2011) |
| "The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated." | 3.74 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection using 5-aminolevulinic acid labeling is one of the most valuable tools available to determine the extent of glioma infiltration, but requires repeated spectroscopic evaluation of the tissue." | 3.74 | Auditory alert system for fluorescence-guided resection of gliomas. ( Fujii, K; Miyajima, Y; Oka, H; Shimizu, S; Suzuki, S; Utsuki, S, 2008) |
| "Malignant gliomas accumulate fluorescing protoporphyrin IX intracellularly after exposure to 5-aminolevulinic acid, a metabolic precursor of haem." | 3.70 | Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. ( Ehrhardt, A; Leonhard, M; Möller, G; Reulen, HJ; Stepp, H; Stummer, W, 1998) |
| "Patients with suspected high-grade brain tumors are given 5-ALA 4 h prior to stereotactic biopsy." | 2.77 | 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies. ( Hefti, M; Moschopulos, M; von Campe, G, 2012) |
| "A better understanding of why cancer cells fluoresce with 5-ALA would improve its use in cancer diagnostics and therapies." | 2.61 | In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid? ( Gleadle, JM; MacGregor, MN; McNicholas, K, 2019) |
| "Malignant gliomas are locally invasive tumors that offer a poor prognosis." | 2.53 | Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016) |
| "Primary brain tumors occur in around 250,000 people per year globally." | 2.52 | Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor. ( Ikegami, Y; Inoue, Y; Ishikawa, T; Kajimoto, Y; Kuroiwa, T, 2015) |
| "FLIm measurements of resection margins presented a range of PpIX and NAD(P)H lifetime values (τPpIX ∼ 3 to 14 ns, τNAD(P)H = 3 to 6 ns) associated with unaffected tissue and areas of low-density tumor infiltration." | 1.72 | First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence. ( Alfonso-García, A; Anbunesan, SN; Bec, J; Bloch, O; Fereidouni, F; Jin, LW; Lee, HS; Marcu, L; Zhou, X, 2022) |
| "Gliomas are infiltrative brain tumors with a margin difficult to identify." | 1.56 | Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy. ( Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D, 2020) |
| "Malignant gliomas are highly invasive, difficult to treat, and account for 2% of cancer deaths worldwide." | 1.46 | ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. ( Chen, Y; Eubanks, JH; Fisher, CJ; Foltz, W; Lilge, L; Niu, C; Sidorova-Darmos, E, 2017) |
| "This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy." | 1.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "Complete removal of malignant gliomas is important for the prognosis in neurosurgery treatment." | 1.39 | Automatic laser scanning ablation system for high-precision treatment of brain tumors. ( Ando, T; Fujiwara, K; Iseki, H; Kobayashi, E; Liao, H; Maruyama, T; Muragaki, Y; Sakuma, I, 2013) |
| "Fluorescence-guided resection (FGR) of brain tumors is an intuitive, practical and emerging technology for visually delineating neoplastic tissue exposed intraoperatively." | 1.36 | Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection. ( Fan, X; Harris, BT; Ji, S; Paulsen, KD; Roberts, DW; Valdés, PA, 2010) |
| "Patients with metastatic brain tumors (n = 11) received 1 g of 5-aminolevulinic acid (5-ALA) perorally 2 h before undergoing surgery." | 1.34 | Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study. ( Fujii, K; Miyajima, Y; Miyoshi, N; Oka, H; Shimizu, S; Suzuki, S; Utsuki, S, 2007) |
| "5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor." | 1.32 | Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003) |
| "We compared resection completeness and residual tumor, determined by histopathology, after white light resection (WLR) using an operating microscope versus additional fluorescence guided resection (FGR)." | 1.32 | Increased brain tumor resection using fluorescence image guidance in a preclinical model. ( Bilbao, JM; Bogaards, A; Collens, SP; Giles, A; Lilge, LD; Lin, A; Muller, PJ; Varma, A; Wilson, BC; Yang, VX, 2004) |
| "For clinical PDT of most adult intracranial neoplasms ALA-induced PpIX appears to be promising, and SnET2 (liposomal) has potential for selective tumor destruction with relative sparing of white matter." | 1.30 | Photodynamic therapy of intracranial tissues: a preclinical comparative study of four different photosensitizers. ( Lilge, L; Wilson, BC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.89) | 18.2507 |
| 2000's | 21 (19.81) | 29.6817 |
| 2010's | 69 (65.09) | 24.3611 |
| 2020's | 14 (13.21) | 2.80 |
| Authors | Studies |
|---|---|
| Black, D | 3 |
| Kaneko, S | 5 |
| Walke, A | 1 |
| König, S | 1 |
| Stummer, W | 13 |
| Suero Molina, E | 6 |
| Alfonso-García, A | 1 |
| Zhou, X | 1 |
| Bec, J | 1 |
| Anbunesan, SN | 1 |
| Fereidouni, F | 1 |
| Jin, LW | 1 |
| Lee, HS | 1 |
| Bloch, O | 1 |
| Marcu, L | 1 |
| Lehtonen, SJR | 1 |
| Vrzakova, H | 1 |
| Paterno, JJ | 1 |
| Puustinen, S | 1 |
| Bednarik, R | 1 |
| Hauta-Kasari, M | 1 |
| Haneishi, H | 1 |
| Immonen, A | 1 |
| Jääskeläinen, JE | 1 |
| Kämäräinen, OP | 1 |
| Elomaa, AP | 1 |
| Marois, M | 2 |
| Olson, JD | 3 |
| Wirth, DJ | 1 |
| Elliott, JT | 1 |
| Fan, X | 5 |
| Davis, SC | 2 |
| Paulsen, KD | 12 |
| Roberts, DW | 13 |
| Mischkulnig, M | 1 |
| Traxler, D | 1 |
| Wadiura, LI | 1 |
| Lang, A | 1 |
| Millesi, M | 1 |
| Kiesel, B | 3 |
| Widhalm, G | 3 |
| McNicholas, K | 1 |
| MacGregor, MN | 1 |
| Gleadle, JM | 1 |
| Schwake, M | 2 |
| Müther, M | 1 |
| Schipmann, S | 3 |
| Köchling, M | 1 |
| Brentrup, A | 1 |
| Piffaretti, D | 1 |
| Burgio, F | 1 |
| Thelen, M | 1 |
| Kaelin-Lang, A | 1 |
| Paganetti, P | 1 |
| Reinert, M | 1 |
| D'Angelo, ML | 1 |
| Leclerc, P | 1 |
| Ray, C | 1 |
| Mahieu-Williame, L | 1 |
| Alston, L | 1 |
| Frindel, C | 1 |
| Brevet, PF | 1 |
| Meyronet, D | 1 |
| Guyotat, J | 3 |
| Montcel, B | 1 |
| Rousseau, D | 1 |
| Moiyadi, A | 1 |
| Shetty, P | 1 |
| Sridhar, E | 1 |
| Gota, V | 1 |
| Gurjar, M | 1 |
| Saicharan, G | 1 |
| Singh, V | 1 |
| Srivastava, S | 1 |
| Stögbauer, L | 1 |
| Jeibmann, A | 2 |
| Warneke, N | 2 |
| Yamamoto, J | 3 |
| Kitagawa, T | 3 |
| Miyaoka, R | 1 |
| Suzuki, K | 1 |
| Takamatsu, S | 1 |
| Saito, T | 1 |
| Nakano, Y | 3 |
| Kim, J- | 2 |
| Jung, T- | 1 |
| Jung, S | 1 |
| Kim, I- | 1 |
| Jang, W- | 1 |
| Moon, K- | 1 |
| Kim, S- | 1 |
| Lee, K- | 1 |
| Müller, P | 1 |
| Abdel Gaber, SA | 1 |
| Zimmermann, W | 1 |
| Wittig, R | 1 |
| Stepp, H | 8 |
| Erkkilä, MT | 1 |
| Reichert, D | 1 |
| Gesperger, J | 1 |
| Roetzer, T | 1 |
| Mercea, PA | 1 |
| Drexler, W | 1 |
| Unterhuber, A | 1 |
| Leitgeb, RA | 1 |
| Woehrer, A | 2 |
| Rueck, A | 1 |
| Andreana, M | 1 |
| Belykh, E | 3 |
| Jubran, JH | 1 |
| George, LL | 1 |
| Bardonova, L | 1 |
| Healey, DR | 1 |
| Georges, JF | 1 |
| Quarles, CC | 1 |
| Eschbacher, JM | 1 |
| Mehta, S | 1 |
| Scheck, AC | 2 |
| Nakaji, P | 3 |
| Preul, MC | 3 |
| Sporns, P | 1 |
| Wölfer, J | 2 |
| Ewelt, C | 5 |
| Ehrhardt, A | 2 |
| Brokinkel, B | 2 |
| Wei, L | 1 |
| Chen, Y | 2 |
| Yin, C | 1 |
| Borwege, S | 1 |
| Sanai, N | 1 |
| Liu, JTC | 1 |
| Cozzens, JW | 1 |
| Lokaitis, BC | 1 |
| Moore, BE | 1 |
| Amin, DV | 1 |
| Espinosa, JA | 1 |
| MacGregor, M | 1 |
| Michael, AP | 1 |
| Jones, BA | 1 |
| Fisher, CJ | 1 |
| Niu, C | 2 |
| Foltz, W | 1 |
| Sidorova-Darmos, E | 1 |
| Eubanks, JH | 1 |
| Lilge, L | 3 |
| Evans, LT | 1 |
| Kolste, KK | 1 |
| Kanick, SC | 2 |
| Bravo, JJ | 2 |
| Wilson, BC | 14 |
| Leblond, F | 7 |
| Dupont, C | 1 |
| Vignion, AS | 1 |
| Mordon, S | 2 |
| Reyns, N | 2 |
| Vermandel, M | 2 |
| Hahn, HK | 1 |
| Kikinis, R | 1 |
| Wårdell, K | 2 |
| Haj-Hosseini, N | 3 |
| Kim, S | 1 |
| Kim, JE | 1 |
| Kim, YH | 1 |
| Hwang, T | 1 |
| Kim, SK | 1 |
| Xu, WJ | 1 |
| Shin, JY | 1 |
| Kim, JI | 1 |
| Choi, H | 1 |
| Kim, HC | 1 |
| Cho, HR | 1 |
| Choi, A | 1 |
| Chowdhury, T | 1 |
| Seo, Y | 1 |
| Dho, YS | 1 |
| Kim, JW | 1 |
| Kim, DG | 1 |
| Park, SH | 1 |
| Kim, H | 1 |
| Choi, SH | 1 |
| Park, S | 1 |
| Lee, SH | 1 |
| Park, CK | 1 |
| Yagi, R | 1 |
| Kawabata, S | 1 |
| Ikeda, N | 1 |
| Nonoguchi, N | 1 |
| Furuse, M | 2 |
| Katayama, Y | 2 |
| Kajimoto, Y | 6 |
| Kuroiwa, T | 6 |
| Miller, EJ | 2 |
| Hu, D | 1 |
| Martirosyan, NL | 1 |
| Woolf, EC | 1 |
| Byvaltsev, VA | 1 |
| Nelson, LY | 2 |
| Seibel, EJ | 2 |
| Nemes, A | 1 |
| Dondrop, J | 1 |
| Schroeteler, J | 1 |
| Senner, V | 1 |
| Jaber, M | 1 |
| Thomas, C | 1 |
| Hasselblatt, M | 1 |
| Grauer, O | 1 |
| Patel, AA | 1 |
| Bozkurt, B | 1 |
| Yağmurlu, K | 1 |
| Robinson, TR | 1 |
| Spetzler, RF | 1 |
| Lawton, MT | 1 |
| Kröger, S | 1 |
| Niehoff, AC | 1 |
| Sperling, M | 1 |
| Paulus, W | 1 |
| Karst, U | 1 |
| Wirth, D | 1 |
| Sibai, M | 1 |
| Olson, J | 1 |
| Paulsen, K | 1 |
| Omoto, K | 1 |
| Matsuda, R | 1 |
| Nakai, Y | 1 |
| Tatsumi, Y | 1 |
| Nakazawa, T | 1 |
| Tanaka, Y | 1 |
| Shida, Y | 1 |
| Murakami, T | 1 |
| Nishimura, F | 1 |
| Nakagawa, I | 1 |
| Motoyama, Y | 1 |
| Nakamura, M | 1 |
| Fujimoto, K | 1 |
| Hiroyuki, N | 1 |
| Kamp, MA | 2 |
| Knipps, J | 3 |
| Neumann, LM | 2 |
| Mijderwijk, HJ | 2 |
| Dibué-Adjei, M | 2 |
| Steiger, HJ | 3 |
| Slotty, PJ | 1 |
| Rapp, M | 2 |
| Cornelius, JF | 3 |
| Sabel, M | 2 |
| Fischer, I | 2 |
| Freiin von Saß, C | 1 |
| Placke, JM | 2 |
| Johansson, A | 2 |
| Faber, F | 1 |
| Kniebühler, G | 1 |
| Sroka, R | 1 |
| Egensperger, R | 1 |
| Beyer, W | 2 |
| Kreth, FW | 3 |
| Roberts, HW | 1 |
| Donati-Bourne, JF | 1 |
| Wilson, VL | 1 |
| Wilton, JC | 1 |
| Fillon, M | 1 |
| Suzuki, T | 2 |
| Wada, S | 1 |
| Eguchi, H | 1 |
| Adachi, J | 1 |
| Mishima, K | 1 |
| Matsutani, M | 1 |
| Nishikawa, R | 2 |
| Nishiyama, M | 1 |
| Chen, X | 2 |
| Wang, C | 1 |
| Teng, L | 2 |
| Liu, Y | 1 |
| Yang, G | 2 |
| Wang, L | 1 |
| Liu, H | 1 |
| Liu, Z | 1 |
| Zhang, D | 1 |
| Zhang, Y | 1 |
| Guan, H | 1 |
| Li, X | 1 |
| Fu, C | 1 |
| Zhao, B | 1 |
| Yin, F | 1 |
| Zhao, S | 1 |
| Traub-Weidinger, T | 1 |
| Preusser, M | 1 |
| Marosi, C | 1 |
| Prayer, D | 1 |
| Hainfellner, JA | 1 |
| Knosp, E | 1 |
| Wolfsberger, S | 1 |
| Miyatake, S | 4 |
| Petterssen, M | 1 |
| Eljamel, S | 2 |
| Kitai, R | 1 |
| Takeuchi, H | 1 |
| Miyoshi, N | 3 |
| Andriana, B | 1 |
| Neishi, H | 1 |
| Hashimoto, N | 2 |
| Kikuta, K | 1 |
| Tanaka, T | 2 |
| Akiba, D | 1 |
| Ueta, K | 2 |
| Nishizawa, S | 2 |
| Ishikawa, T | 1 |
| Inoue, Y | 1 |
| Ikegami, Y | 1 |
| Richter, JC | 1 |
| Hallbeck, M | 1 |
| Leroy, HA | 1 |
| Lejeune, JP | 1 |
| Valdés, PA | 9 |
| Jacobs, V | 1 |
| Harris, BT | 6 |
| Pallud, J | 1 |
| Armoiry, X | 2 |
| Pavlov, V | 1 |
| Metellus, P | 1 |
| Markwardt, NA | 1 |
| Hollnburger, B | 1 |
| Zelenkov, P | 1 |
| Rühm, A | 1 |
| Babič, A | 1 |
| Herceg, V | 1 |
| Ateb, I | 1 |
| Allémann, E | 1 |
| Lange, N | 1 |
| Ma, R | 1 |
| Watts, C | 1 |
| Schimanski, A | 1 |
| Ebbert, L | 1 |
| Sabel, MC | 1 |
| Finocchiaro, G | 1 |
| Lamszus, K | 1 |
| Etminan, N | 1 |
| Fischer, JC | 1 |
| Sorg, RV | 1 |
| Pustogarov, N | 1 |
| Panteleev, D | 1 |
| Goryaynov, SA | 1 |
| Ryabova, AV | 1 |
| Rybalkina, EY | 1 |
| Revishchin, A | 1 |
| Potapov, AA | 2 |
| Pavlova, G | 1 |
| Kamp, M | 1 |
| Wang, W | 1 |
| Tabu, K | 1 |
| Hagiya, Y | 1 |
| Sugiyama, Y | 1 |
| Kokubu, Y | 1 |
| Murota, Y | 1 |
| Ogura, SI | 1 |
| Taga, T | 1 |
| Gibbs-Strauss, SL | 1 |
| O'Hara, JA | 1 |
| Srinivasan, S | 1 |
| Hoopes, PJ | 1 |
| Hasan, T | 1 |
| Pogue, BW | 2 |
| Ji, S | 3 |
| El-Zaria, ME | 1 |
| Ban, HS | 1 |
| Nakamura, H | 1 |
| Fontaine, KM | 1 |
| Hartov, A | 2 |
| Lollis, SS | 1 |
| Tosteson, TD | 3 |
| Engh, JA | 1 |
| Tanaka, S | 1 |
| Nakada, M | 1 |
| Hayashi, Y | 2 |
| Nakada, S | 1 |
| Sawada-Kitamura, S | 1 |
| Furuyama, N | 1 |
| Kamide, T | 1 |
| Yano, S | 1 |
| Hamada, J | 1 |
| Ando, T | 2 |
| Kobayashi, E | 3 |
| Liao, H | 2 |
| Maruyama, T | 3 |
| Muragaki, Y | 3 |
| Iseki, H | 3 |
| Kubo, O | 1 |
| Sakuma, I | 3 |
| Ikeda, D | 1 |
| Chiocca, EA | 1 |
| Kim, A | 4 |
| Erkmen, K | 1 |
| Simmons, NE | 1 |
| Brantsch, M | 1 |
| Moses, ZB | 2 |
| Arita, H | 1 |
| Kinoshita, M | 1 |
| Kagawa, N | 1 |
| Fujimoto, Y | 1 |
| Kishima, H | 1 |
| Yoshimine, T | 1 |
| Hennig, G | 1 |
| von Campe, G | 1 |
| Moschopulos, M | 1 |
| Hefti, M | 1 |
| Konecky, SD | 1 |
| Owen, CM | 1 |
| Rice, T | 1 |
| Kolste, K | 1 |
| Tromberg, BJ | 1 |
| Zhao, SG | 1 |
| Chen, XF | 1 |
| Wang, LG | 1 |
| Han, DY | 1 |
| Yang, MC | 1 |
| Wang, DY | 1 |
| Shi, C | 1 |
| Liu, YH | 1 |
| Zheng, BJ | 1 |
| Shi, CB | 1 |
| Gao, X | 1 |
| Rainov, NG | 1 |
| Fujiwara, K | 1 |
| Belden, CJ | 1 |
| Colditz, MJ | 2 |
| Jeffree, RL | 2 |
| Leyen, Kv | 1 |
| Jacobs, VL | 1 |
| Gavrilov, AG | 1 |
| Goriaĭnov, SA | 1 |
| Gol'bin, DA | 1 |
| Zelenkov, PV | 1 |
| Kobiakov, GL | 1 |
| Okhlopkov, VA | 1 |
| Zhukov, VIu | 1 |
| Shishkina, LV | 1 |
| Shukhraĭ, VA | 1 |
| Loshchenov, VB | 1 |
| Savel'eva, TA | 1 |
| Grachev, PV | 1 |
| Kholodtsova, MN | 1 |
| Kuz'min, SG | 1 |
| Vorozhtsov, GN | 1 |
| Jacquesson, T | 1 |
| Ducray, F | 1 |
| Maucort-Boulch, D | 1 |
| Louis-Tisserand, G | 1 |
| Mbaye, M | 1 |
| Pelissou-Guyotat, I | 1 |
| Reulen, HJ | 2 |
| Novotny, A | 1 |
| Tonn, JC | 1 |
| Wu, SM | 1 |
| Ren, QG | 1 |
| Zhou, MO | 1 |
| Peng, Q | 2 |
| Chen, JY | 1 |
| Olivo, M | 1 |
| Bogaards, A | 1 |
| Varma, A | 1 |
| Collens, SP | 1 |
| Lin, A | 1 |
| Giles, A | 1 |
| Yang, VX | 1 |
| Bilbao, JM | 1 |
| Lilge, LD | 1 |
| Muller, PJ | 1 |
| Hirschberg, H | 1 |
| Sørensen, DR | 1 |
| Angell-Petersen, E | 1 |
| Tromberg, B | 1 |
| Sun, CH | 1 |
| Spetalen, S | 1 |
| Madsen, S | 1 |
| Yamaguchi, F | 1 |
| Teramoto, A | 1 |
| Takahashi, H | 1 |
| Inoue, H | 1 |
| Shibata, MA | 1 |
| Ogawa, N | 1 |
| Otsuki, Y | 1 |
| Ishihara, R | 1 |
| Watanabe, T | 1 |
| Yoshino, A | 1 |
| Fukushima, T | 1 |
| Sakatani, K | 1 |
| Noguchi, M | 1 |
| Aoki, E | 1 |
| Yoshida, D | 1 |
| Omori, S | 1 |
| Nakamura, K | 1 |
| Tamura, Y | 1 |
| Miki, Y | 1 |
| Tsuji, M | 1 |
| Beck, TJ | 1 |
| Mehrkens, JH | 1 |
| Obermeier, A | 1 |
| Baumgartner, R | 1 |
| Lassalle, HP | 1 |
| Baumann, H | 1 |
| Strauss, WS | 1 |
| Schneckenburger, H | 1 |
| Beck, T | 1 |
| Pongratz, T | 1 |
| Meinel, T | 1 |
| Tonn, JCh | 1 |
| Utsuki, S | 2 |
| Oka, H | 2 |
| Miyajima, Y | 2 |
| Shimizu, S | 2 |
| Suzuki, S | 2 |
| Fujii, K | 2 |
| Möller, G | 1 |
| Leonhard, M | 1 |
| Eléouet, S | 1 |
| Rousset, N | 1 |
| Carré, J | 1 |
| Vonarx, V | 1 |
| Vilatte, C | 1 |
| Louët, C | 1 |
| Lajat, Y | 1 |
| Patrice, T | 1 |
| Portnoy, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488] | Phase 1 | 540 participants (Anticipated) | Interventional | 2014-07-31 | Active, not recruiting | ||
| Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas[NCT04937244] | Phase 4 | 10 participants (Anticipated) | Interventional | 2021-05-13 | Recruiting | ||
| Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker: Correlation With Preoperative MR, ALA-induced PpIX Fluorescence, and Histopathology[NCT02691923] | Phase 2 | 30 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737] | 43 participants (Actual) | Interventional | 2019-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for protoporphyrin ix and Benign Neoplasms, Brain
| Article | Year |
|---|---|
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Brain Neoplasms; Coproporphyrinogens; Ferrochelat | 2019 |
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Mitochondria; Photosensitizing A | 2020 |
The use of live fluorescence staining techniques in surgery: a review.
Topics: Brain Neoplasms; Coronary Artery Bypass; Endometriosis; Female; Fluorescein; Fluorescein Angiography | 2013 |
Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, | 2015 |
Fluorescence guided resection and glioblastoma in 2015: A review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Photosensitizing Agents; P | 2015 |
5-Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Surgery of High-Grade Gliomas: A Systematic Review.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Microscopy, Fluores | 2016 |
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neurons; Neurosurgical Procedure | 2016 |
[Intraoperative photo-dynamic diagnosis of brain tumors].
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat | 2009 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies.
Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Fluorescence; Glioma; Humans; Magnetic | 2012 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Ph | 2012 |
[Surgery of high-grade gliomas guided by fluorescence: a retrospective study of 22 patients].
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Brain | 2013 |
[Intraoperative photodynamic diagnosis using 5-ALA for glioma surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Monitoring, Intraoperative; Neoplasm, Residual | 2005 |
Repetitive photodynamic therapy of malignant brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Light; Photochemotherapy; Photosensit | 2006 |
[Intraoperative photodynamic diagnosis of human glioma using ALA induced protoporphyrin IX].
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Male; Mice; Middle Aged; Monitoring, | 2001 |
8 trials available for protoporphyrin ix and Benign Neoplasms, Brain
| Article | Year |
|---|---|
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Craniotomy; Dose-Re | 2017 |
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye | 2018 |
Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Biopsy; Brain; Brain Neoplasms; Female; Fluorescence; | 2013 |
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl | 2011 |
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy, Needle; Brain Neoplasms; Female; Gliobl | 2012 |
Fluorescence-guided resections of malignant gliomas--an overview.
Topics: Aminolevulinic Acid; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Fluorescenc | 2003 |
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Fluoresc | 2007 |
Heterogeneity of delta-aminolevulinic acid-induced protoporphyrin IX fluorescence in human glioma cells and leukemic lymphocytes.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Female; Glioblastoma; | 2000 |
84 other studies available for protoporphyrin ix and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery.
Topics: Biomarkers, Tumor; Blood-Brain Barrier; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neuroglia | 2021 |
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Margins of Excision; Photosensitizing Ag | 2022 |
Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Hyperspectral Imaging; Photosensitizing Agents | 2022 |
A birefringent spectral demultiplexer enables fast hyper-spectral imaging of protoporphyrin IX during neurosurgery.
Topics: Brain Neoplasms; Fluorescent Dyes; Humans; Neurosurgery; Optical Imaging; Protoporphyrins | 2023 |
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Microscopy, Fluorescence; Photos | 2023 |
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.
Topics: Adolescent; Aminolevulinic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Fluorescen | 2019 |
Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell | 2019 |
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Compute | 2020 |
Objective assessment of intraoperative tumor fluorescence reveals biological heterogeneity within glioblastomas: a biometric study.
Topics: Brain Neoplasms; Glioblastoma; Humans; Optical Imaging; Prospective Studies; Protoporphyrins; Sensit | 2020 |
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fl | 2020 |
Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Cell Movement; Cerebral Ventricles; DNA Modification Met | 2021 |
ABCG2 influence on the efficiency of photodynamic therapy in glioblastoma cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell | 2020 |
Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Levulinic Acids; NAD; Necrosis; N | 2020 |
Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Cell | 2021 |
Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Chromosome Deletion; Female; Fluorescence; Glioma; Huma | 2022 |
Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescein; Fluorescence; Fluorescent Dyes; Glioma; H | 2018 |
Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Disease-Free Survival; Glioma; | 2017 |
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor | 2017 |
Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Electronic Data Processing; Glioma; Humans; Neuros | 2017 |
Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models.
Topics: Algorithms; Brain Neoplasms; Computer Simulation; Glioblastoma; Humans; Models, Biological; Monte Ca | 2018 |
Auditory display for fluorescence-guided open brain tumor surgery.
Topics: Brain; Brain Neoplasms; Fluorescence; Humans; Neurosurgical Procedures; Photosensitizing Agents; Pro | 2018 |
Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Fluorescence; Fluorescent Dyes; Gene Express | 2017 |
Intraoperative 5-aminolevulinic acid-induced photodynamic diagnosis of metastatic brain tumors with histopathological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Fluorescence; Humans; Intraoperati | 2017 |
Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biotransformation; Brain Neoplasms; Cell Line, T | 2018 |
In-Vitro Use of 5-ALA for Photodynamic Therapy in Pediatric Brain Tumors.
Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Child; | 2018 |
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
Topics: Adult; Aminolevulinic Acid; Biomarkers; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma; Human | 2019 |
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent D | 2018 |
Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Laser Therapy; Mass Spectr | 2018 |
Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.
Topics: Brain; Brain Neoplasms; Equipment Design; Feasibility Studies; Glioma; Humans; Optical Imaging; Phan | 2018 |
Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cel
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blotting, Western; Bra | 2019 |
Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Kineti | 2019 |
Is the Intensity of 5-Aminolevulinic Acid-Derived Fluorescence Related to the Light Source?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Light; Neurosurgical Procedures; | 2019 |
Quantification of PpIX-fluorescence of cerebral metastases: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescent Dyes; Foll | 2019 |
New technique may improve brain tumor margin imaging resections.
Topics: Animals; Antibodies, Monoclonal; Biomedical Engineering; Brain Neoplasms; Contrast Media; Fluorescen | 2013 |
Cadherin 13 overexpression as an important factor related to the absence of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma.
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Cadherins; Cell Line, Tumor; Fluorescence; Gene Ex | 2013 |
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Astrocytes; Brain Neoplasms; Calcitriol; Cell Line, Tumor; Cell Survival; Enzym | 2014 |
5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Female; Fluorescence; Glioma; | 2013 |
A surgical loupe system for observing protoporphyrin IX fluorescence in high-grade gliomas after administering 5-aminolevulinic acid.
Topics: Amino Acids, Neutral; Brain Neoplasms; Equipment Design; Equipment Failure Analysis; Eyeglasses; Flu | 2013 |
Protoporphyrin-IX fluorescence guided surgical resection in high-grade gliomas: The potential impact of human colour perception.
Topics: Brain Neoplasms; Color Perception; Female; Fluorescent Dyes; Glioma; Humans; Male; Microscopy, Fluor | 2014 |
[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases].
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Count; Cell Line, Tumor; Female; Gl | 2014 |
5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cytoplasm; Glioma; Humans; In Vitro | 2015 |
Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Fluorescence; | 2015 |
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; | 2015 |
405 nm versus 633 nm for protoporphyrin IX excitation in fluorescence-guided stereotactic biopsy of brain tumors.
Topics: Biopsy; Brain Neoplasms; Fluorescence; Humans; Phantoms, Imaging; Protoporphyrins; Reproducibility o | 2016 |
Tunable phosphatase-sensitive stable prodrugs of 5-aminolevulinic acid for tumor fluorescence photodetection.
Topics: Alkaline Phosphatase; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Chick Embryo; | 2016 |
Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Syner | 2016 |
Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Coproporphyrinogen Oxidase; Fluorescence; Gl | 2017 |
5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.
Topics: Aminolevulinic Acid; Apoptosis; Biological Transport; Brain Neoplasms; Cell Death; Cell Line, Tumor; | 2017 |
Minispectrometer with handheld probe for 5-ALA based fluorescence-guided surgery of brain tumors: Preliminary study for clinical applications.
Topics: Brain Neoplasms; Glioblastoma; Humans; Meningioma; Neurosurgical Procedures; Photosensitizing Agents | 2017 |
Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biotransforma | 2017 |
Diagnostic detection of diffuse glioma tumors in vive with molecular fluorescent probe-based transmission spectroscopy.
Topics: Animals; Biophysical Phenomena; Brain Neoplasms; Cell Line, Tumor; ErbB Receptors; Fluorescent Dyes; | 2009 |
Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection.
Topics: Aged; Brain; Brain Neoplasms; Glioblastoma; Gliosarcoma; Humans; Image Interpretation, Computer-Assi | 2010 |
Boron-containing protoporphyrin IX derivatives and their modification for boron neutron capture therapy: synthesis, characterization, and comparative in vitro toxicity evaluation.
Topics: Animals; Antineoplastic Agents; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Hu | 2010 |
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Data Interpretation, Statisti | 2011 |
Improving intraoperative visualization of anaplastic foci within gliomas.
Topics: Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Fluorescence; Glioma; Humans; Protoporphyri | 2010 |
Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enz | 2011 |
Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents; Protoporphyrins; Spec | 2011 |
Measuring versus seeing.
Topics: Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Fluorescence; Humans; M | 2011 |
Fluorescence illuminates the way ...
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Male; Monitoring, Intraope | 2011 |
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Female; Fluoresce | 2011 |
¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Carbon Radioisotopes; Cell Count; Cell Proliferat | 2012 |
Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy.
Topics: Absorption; Algorithms; Aminolevulinic Acid; Brain Neoplasms; Computer Simulation; Finite Element An | 2011 |
Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Contrast Media; Glioma; Mice; Mice, Nude; Microscopy, Fl | 2012 |
A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery.
Topics: Animals; Brain Neoplasms; Humans; Male; Mice; Phantoms, Imaging; Protoporphyrins; Spectrometry, Fluo | 2012 |
Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.
Topics: Aminolevulinic Acid; Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Brain; Brain N | 2013 |
Automatic laser scanning ablation system for high-precision treatment of brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Equipment Design; Glioma; Humans; Laser Therap | 2013 |
Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.
Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Craniotomy; Creatinine; Female; Gadoliniu | 2012 |
Quantitative, spectrally-resolved intraoperative fluorescence imaging.
Topics: Animals; Brain Neoplasms; Fluorescence; Fluorescent Dyes; Glioma; Humans; Intraoperative Period; Opt | 2012 |
[Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery].
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Humans; Male; Middle Aged; Ne | 2012 |
Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line; Cerebellum; Glioma; Humans; Neuroblastoma; | 2003 |
Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Microscopy, Fluorescence; Protoporphyrins; Rab | 2004 |
Increased brain tumor resection using fluorescence image guidance in a preclinical model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Microscopy; Models, Animal; Neoplasm, Residua | 2004 |
[5-ALA fluorescence guided tumor resection].
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Middle Aged; Mitochondri | 2006 |
Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes | 2007 |
Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas.
Topics: Aged; Aminolevulinic Acid; Astrocytoma; Brain Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm | 2007 |
A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection.
Topics: Animals; Brain Neoplasms; Equipment Design; Equipment Failure Analysis; Laser Therapy; Microscopy, F | 2006 |
Endoscopic identification and biopsy sampling of an intraventricular malignant glioma using a 5-aminolevulinic acid-induced protoporphyrin IX fluorescence imaging system. Technical note.
Topics: Aminolevulinic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Female; Fluorescence; Humans; Middle Aged | 2007 |
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Feasibility Studies; Glioma; Humans; Magnetic Res | 2007 |
Cell-substrate topology upon ALA-PDT using variable-angle total internal reflection fluorescence microscopy (VA-TIRFM).
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Drug Screening Assays, Antitu | 2007 |
Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study.
Topics: Aminolevulinic Acid; Brain Neoplasms; Humans; Microscopy, Fluorescence; Neurosurgical Procedures; Ph | 2007 |
Auditory alert system for fluorescence-guided resection of gliomas.
Topics: Acoustic Stimulation; Brain Neoplasms; Diagnosis, Computer-Assisted; Glioma; Humans; Neoplasm Invasi | 2008 |
Photodynamic therapy of intracranial tissues: a preclinical comparative study of four different photosensitizers.
Topics: Animals; Argon; Brain; Brain Neoplasms; Dihematoporphyrin Ether; Dose-Response Relationship, Drug; E | 1998 |
Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Mi | 1998 |
Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Dihematoporphyrin Ether; Indoles; M | 2000 |