protoporphyrin ix has been researched along with Astrocytoma, Grade IV in 39 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the degree of tumor cell infiltration in the tumor cavity and ventricle wall based on fluorescent signals of 5-aminolevulinic acid (5-ALA) after removal of the magnetic resonance (MR)-enhancing area and analyzed its prognostic significance in glioblastoma." | 8.02 | Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma. ( Jang, W-; Jung, S; Jung, T-; Kim, I-; Kim, J-; Kim, S-; Lee, K-; Moon, K-, 2021) |
| "The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed." | 7.96 | Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020) |
| "Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved." | 7.91 | Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. ( Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W, 2019) |
| "Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment." | 7.85 | Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma. ( Cho, HR; Choi, A; Choi, H; Choi, SH; Chowdhury, T; Dho, YS; Hwang, T; Kim, DG; Kim, H; Kim, HC; Kim, JE; Kim, JI; Kim, JW; Kim, S; Kim, SK; Kim, YH; Lee, SH; Park, CK; Park, S; Park, SH; Seo, Y; Shin, JY; Xu, WJ, 2017) |
| "PpIX synthesis after incubation with delta-aminolevulinic acid (ALA) is highly variable from one cell to another within a single cell population and in human glioblastomas in vivo." | 7.70 | Protoporphyrin IX fluorescence kinetics in C6 glioblastoma cells after delta-aminolevulinic acid incubation: effect of a protoporphyrinogen oxidase inhibitor. ( Carre, J; Eleouet, S; Heyman, D; Lajat, Y; Patrice, T; Rousset, N; Vonarx, V, 1999) |
| "Interstitial photodynamic therapy (iPDT) of non-resectable recurrent glioblastoma using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has shown a promising outcome." | 5.17 | Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis. ( Beyer, W; Egensperger, R; Faber, F; Johansson, A; Kniebühler, G; Kreth, FW; Sroka, R; Stepp, H, 2013) |
| "This study investigated the degree of tumor cell infiltration in the tumor cavity and ventricle wall based on fluorescent signals of 5-aminolevulinic acid (5-ALA) after removal of the magnetic resonance (MR)-enhancing area and analyzed its prognostic significance in glioblastoma." | 4.02 | Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma. ( Jang, W-; Jung, S; Jung, T-; Kim, I-; Kim, J-; Kim, S-; Lee, K-; Moon, K-, 2021) |
| "The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed." | 3.96 | Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020) |
| "Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved." | 3.91 | Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. ( Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W, 2019) |
| "Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment." | 3.85 | Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma. ( Cho, HR; Choi, A; Choi, H; Choi, SH; Chowdhury, T; Dho, YS; Hwang, T; Kim, DG; Kim, H; Kim, HC; Kim, JE; Kim, JI; Kim, JW; Kim, S; Kim, SK; Kim, YH; Lee, SH; Park, CK; Park, S; Park, SH; Seo, Y; Shin, JY; Xu, WJ, 2017) |
| " The prodrugs display reduced acute toxicity compared to 5-ALA-Hex with superior dose response profiles of protoporphyrin IX synthesis and fluorescence intensity in human glioblastoma cells in vitro." | 3.83 | Tunable phosphatase-sensitive stable prodrugs of 5-aminolevulinic acid for tumor fluorescence photodetection. ( Allémann, E; Ateb, I; Babič, A; Herceg, V; Lange, N, 2016) |
| "7h) PDT treatment in a nude mouse model of human glioblastoma by using organic light emitting diode (OLED) with single dose of 5-aminolevulinic acid (ALA) administration as photosensitizer." | 3.81 | Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED). ( Chen, PH; Chiou, SH; Dong, CY; Guo, HW; Ho, MH; Hsieh, YS; Huang, WT; Lee, YJ; Lin, LT; Wang, HW, 2015) |
| "Good quality protoporphyrin IX fluorescence was acquired using the surgical loupe system during glioblastoma resection, which was nearly identical to that acquired by fluorescent microscopy." | 3.79 | A surgical loupe system for observing protoporphyrin IX fluorescence in high-grade gliomas after administering 5-aminolevulinic acid. ( Furuse, M; Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2013) |
| " In recent clinical studies, fluorescence monitoring during iPDT of glioblastoma multiforme has revealed patient-specific accumulation of photosensitizer (aminolevulinic acid (ALA) induced protoporphyrin IX, PpIX) and its photobleaching kinetics." | 3.77 | Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy. ( Hennig, G; Johansson, A; Stepp, H, 2011) |
| " It is shown that sublethal PDT of human WiDr adenocarcinoma cells and D54Mg glioblastoma cells with 5-aminolevulinic acid (ALA), disulfonated tetraphenylporphyrine (TPPS(2a)), or MitoTracker Red (MTR) inhibits their trypsin-induced detachment from a plastic substratum." | 3.72 | Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum. ( Juzeniene, A; Ma, LW; Moan, J; Uzdensky, A, 2004) |
| "PpIX synthesis after incubation with delta-aminolevulinic acid (ALA) is highly variable from one cell to another within a single cell population and in human glioblastomas in vivo." | 3.70 | Protoporphyrin IX fluorescence kinetics in C6 glioblastoma cells after delta-aminolevulinic acid incubation: effect of a protoporphyrinogen oxidase inhibitor. ( Carre, J; Eleouet, S; Heyman, D; Lajat, Y; Patrice, T; Rousset, N; Vonarx, V, 1999) |
| "Patients with suspected high-grade brain tumors are given 5-ALA 4 h prior to stereotactic biopsy." | 2.77 | 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies. ( Hefti, M; Moschopulos, M; von Campe, G, 2012) |
| "Glioblastoma multiforme is an aggressive type of brain cancer with high recurrence rates due to the presence of radioresistant cells remaining after tumor resection." | 1.91 | Combining Pr ( Bietar, K; Capobianco, JA; Mandl, GA; Maurizio, SL; Stochaj, U; Tessitore, G; Vettier, F, 2023) |
| "Fluorescence-guided resection (FGR) of brain tumors is an intuitive, practical and emerging technology for visually delineating neoplastic tissue exposed intraoperatively." | 1.36 | Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection. ( Fan, X; Harris, BT; Ji, S; Paulsen, KD; Roberts, DW; Valdés, PA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.56) | 18.2507 |
| 2000's | 6 (15.38) | 29.6817 |
| 2010's | 26 (66.67) | 24.3611 |
| 2020's | 6 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Mandl, GA | 1 |
| Vettier, F | 1 |
| Tessitore, G | 1 |
| Maurizio, SL | 1 |
| Bietar, K | 1 |
| Stochaj, U | 1 |
| Capobianco, JA | 1 |
| Piffaretti, D | 1 |
| Burgio, F | 1 |
| Thelen, M | 1 |
| Kaelin-Lang, A | 1 |
| Paganetti, P | 1 |
| Reinert, M | 1 |
| D'Angelo, ML | 1 |
| Moiyadi, A | 1 |
| Shetty, P | 1 |
| Sridhar, E | 1 |
| Gota, V | 1 |
| Gurjar, M | 1 |
| Saicharan, G | 1 |
| Singh, V | 1 |
| Srivastava, S | 1 |
| Kaneko, S | 1 |
| Brokinkel, B | 1 |
| Suero Molina, E | 1 |
| Warneke, N | 1 |
| Holling, M | 1 |
| Bunk, EC | 1 |
| Hess, K | 1 |
| Senner, V | 1 |
| Paulus, W | 2 |
| Stummer, W | 2 |
| Kim, J- | 2 |
| Jung, T- | 1 |
| Jung, S | 1 |
| Kim, I- | 1 |
| Jang, W- | 1 |
| Moon, K- | 1 |
| Kim, S- | 1 |
| Lee, K- | 1 |
| Müller, P | 1 |
| Abdel Gaber, SA | 1 |
| Zimmermann, W | 2 |
| Wittig, R | 1 |
| Stepp, H | 4 |
| Shono, K | 1 |
| Mizobuchi, Y | 1 |
| Yamaguchi, I | 1 |
| Nakajima, K | 1 |
| Fujiwara, Y | 1 |
| Fujihara, T | 1 |
| Kitazato, K | 1 |
| Matsuzaki, K | 1 |
| Uto, Y | 1 |
| Sampetrean, O | 1 |
| Saya, H | 1 |
| Takagi, Y | 1 |
| Dupont, C | 1 |
| Vignion, AS | 1 |
| Mordon, S | 2 |
| Reyns, N | 2 |
| Vermandel, M | 2 |
| Kim, S | 1 |
| Kim, JE | 1 |
| Kim, YH | 1 |
| Hwang, T | 1 |
| Kim, SK | 1 |
| Xu, WJ | 1 |
| Shin, JY | 1 |
| Kim, JI | 1 |
| Choi, H | 1 |
| Kim, HC | 1 |
| Cho, HR | 1 |
| Choi, A | 1 |
| Chowdhury, T | 1 |
| Seo, Y | 1 |
| Dho, YS | 1 |
| Kim, JW | 1 |
| Kim, DG | 1 |
| Park, SH | 1 |
| Kim, H | 1 |
| Choi, SH | 1 |
| Park, S | 1 |
| Lee, SH | 1 |
| Park, CK | 1 |
| Kröger, S | 1 |
| Niehoff, AC | 1 |
| Jeibmann, A | 1 |
| Sperling, M | 1 |
| Karst, U | 1 |
| Shi, L | 1 |
| Buchner, A | 1 |
| Pohla, H | 1 |
| Pongratz, T | 1 |
| Rühm, A | 1 |
| Gederaas, OA | 1 |
| Zhang, L | 1 |
| Wang, X | 1 |
| Sroka, R | 2 |
| Johansson, A | 2 |
| Faber, F | 1 |
| Kniebühler, G | 1 |
| Egensperger, R | 1 |
| Beyer, W | 1 |
| Kreth, FW | 1 |
| Suzuki, T | 2 |
| Wada, S | 1 |
| Eguchi, H | 1 |
| Adachi, J | 1 |
| Mishima, K | 1 |
| Matsutani, M | 1 |
| Nishikawa, R | 1 |
| Nishiyama, M | 1 |
| Fisher, CJ | 1 |
| Niu, CJ | 2 |
| Lai, B | 1 |
| Chen, Y | 1 |
| Kuta, V | 1 |
| Lilge, LD | 1 |
| Kuroiwa, T | 1 |
| Kajimoto, Y | 1 |
| Furuse, M | 1 |
| Miyatake, S | 1 |
| Albert, I | 1 |
| Hefti, M | 2 |
| Luginbuehl, V | 1 |
| Guo, HW | 1 |
| Lin, LT | 1 |
| Chen, PH | 1 |
| Ho, MH | 1 |
| Huang, WT | 1 |
| Lee, YJ | 1 |
| Chiou, SH | 1 |
| Hsieh, YS | 1 |
| Dong, CY | 1 |
| Wang, HW | 1 |
| Leroy, HA | 1 |
| Lejeune, JP | 1 |
| Fisher, C | 1 |
| Scheffler, K | 1 |
| Wan, R | 1 |
| Maleki, H | 1 |
| Liu, H | 1 |
| Sun, Y | 1 |
| A Simmons, C | 1 |
| Birngruber, R | 1 |
| Lilge, L | 1 |
| Guyotat, J | 2 |
| Pallud, J | 1 |
| Armoiry, X | 2 |
| Pavlov, V | 1 |
| Metellus, P | 1 |
| Lawrence, JE | 1 |
| Steele, CJ | 1 |
| Rovin, RA | 1 |
| Belton, RJ | 1 |
| Winn, RJ | 1 |
| Ju, D | 1 |
| Yamaguchi, F | 1 |
| Zhan, G | 1 |
| Higuchi, T | 1 |
| Asakura, T | 1 |
| Morita, A | 1 |
| Orimo, H | 1 |
| Hu, S | 1 |
| Babič, A | 1 |
| Herceg, V | 1 |
| Ateb, I | 1 |
| Allémann, E | 1 |
| Lange, N | 1 |
| Schimanski, A | 1 |
| Ebbert, L | 1 |
| Sabel, MC | 1 |
| Finocchiaro, G | 1 |
| Lamszus, K | 1 |
| Ewelt, C | 1 |
| Etminan, N | 1 |
| Fischer, JC | 1 |
| Sorg, RV | 1 |
| Cornelius, JF | 1 |
| Placke, JM | 1 |
| Knipps, J | 1 |
| Fischer, I | 1 |
| Kamp, M | 1 |
| Steiger, HJ | 1 |
| Valdés, PA | 1 |
| Fan, X | 1 |
| Ji, S | 1 |
| Harris, BT | 1 |
| Paulsen, KD | 1 |
| Roberts, DW | 1 |
| Tanaka, S | 1 |
| Nakada, M | 1 |
| Hayashi, Y | 2 |
| Nakada, S | 1 |
| Sawada-Kitamura, S | 1 |
| Furuyama, N | 1 |
| Kamide, T | 1 |
| Yano, S | 1 |
| Hamada, J | 1 |
| Berkovitch-Luria, G | 1 |
| Weitman, M | 1 |
| Nudelman, A | 1 |
| Rephaeli, A | 1 |
| Malik, Z | 1 |
| Hennig, G | 1 |
| Samkoe, KS | 1 |
| Gibbs-Strauss, SL | 1 |
| Yang, HH | 1 |
| Khan Hekmatyar, S | 1 |
| Jack Hoopes, P | 1 |
| O'Hara, JA | 1 |
| Kauppinen, RA | 1 |
| Pogue, BW | 1 |
| von Campe, G | 1 |
| Moschopulos, M | 1 |
| Jacquesson, T | 1 |
| Ducray, F | 1 |
| Maucort-Boulch, D | 1 |
| Louis-Tisserand, G | 1 |
| Mbaye, M | 1 |
| Pelissou-Guyotat, I | 1 |
| Uzdensky, A | 1 |
| Juzeniene, A | 1 |
| Ma, LW | 1 |
| Moan, J | 1 |
| Duffner, F | 1 |
| Ritz, R | 1 |
| Freudenstein, D | 1 |
| Weller, M | 1 |
| Dietz, K | 1 |
| Wessels, J | 1 |
| Sailer, R | 1 |
| Strauss, WS | 2 |
| Wagner, M | 1 |
| Emmert, H | 1 |
| Schneckenburger, H | 2 |
| Lassalle, HP | 1 |
| Baumann, H | 1 |
| Carre, J | 2 |
| Eleouet, S | 2 |
| Rousset, N | 2 |
| Vonarx, V | 2 |
| Heyman, D | 1 |
| Lajat, Y | 2 |
| Patrice, T | 2 |
| Vilatte, C | 1 |
| Louët, C | 1 |
| Madsen, SJ | 1 |
| Sun, CH | 1 |
| Tromberg, BJ | 1 |
| Wallace, VP | 1 |
| Hirschberg, H | 1 |
3 reviews available for protoporphyrin ix and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Fluorescence guided resection and glioblastoma in 2015: A review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Photosensitizing Agents; P | 2015 |
5-Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Surgery of High-Grade Gliomas: A Systematic Review.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Microscopy, Fluores | 2016 |
[Surgery of high-grade gliomas guided by fluorescence: a retrospective study of 22 patients].
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Brain | 2013 |
3 trials available for protoporphyrin ix and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Biopsy; Brain; Brain Neoplasms; Female; Fluorescence; | 2013 |
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy, Needle; Brain Neoplasms; Female; Gliobl | 2012 |
Heterogeneity of delta-aminolevulinic acid-induced protoporphyrin IX fluorescence in human glioma cells and leukemic lymphocytes.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Female; Glioblastoma; | 2000 |
33 other studies available for protoporphyrin ix and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Combining Pr
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioblastoma; Humans; Photochemotherapy; X-Rays | 2023 |
Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell | 2019 |
Objective assessment of intraoperative tumor fluorescence reveals biological heterogeneity within glioblastomas: a biometric study.
Topics: Brain Neoplasms; Glioblastoma; Humans; Optical Imaging; Prospective Studies; Protoporphyrins; Sensit | 2020 |
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; | 2020 |
Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Cell Movement; Cerebral Ventricles; DNA Modification Met | 2021 |
ABCG2 influence on the efficiency of photodynamic therapy in glioblastoma cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell | 2020 |
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tu | 2021 |
Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models.
Topics: Algorithms; Brain Neoplasms; Computer Simulation; Glioblastoma; Humans; Models, Biological; Monte Ca | 2018 |
Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Fluorescence; Fluorescent Dyes; Gene Express | 2017 |
Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Laser Therapy; Mass Spectr | 2018 |
Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Drug Synergi | 2019 |
Cadherin 13 overexpression as an important factor related to the absence of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma.
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Cadherins; Cell Line, Tumor; Fluorescence; Gene Ex | 2013 |
Modulation of PPIX synthesis and accumulation in various normal and glioma cell lines by modification of the cellular signaling and temperature.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cytoplasm; Erlotinib Hydrochloride; Glioblastoma; Huma | 2013 |
A surgical loupe system for observing protoporphyrin IX fluorescence in high-grade gliomas after administering 5-aminolevulinic acid.
Topics: Amino Acids, Neutral; Brain Neoplasms; Equipment Design; Equipment Failure Analysis; Eyeglasses; Flu | 2013 |
Physiological oxygen concentration alters glioma cell malignancy and responsiveness to photodynamic therapy in vitro.
Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents, Phytogenic; Camptothecin; Caspase 3; Cell Culture | 2014 |
Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED).
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioblastoma; Humans; Mice; Mice, Nude; Photoc | 2015 |
Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells.
Topics: Acrylic Resins; Cell Count; Cell Line, Tumor; Cell Proliferation; Cellular Microenvironment; Elastic | 2015 |
Dexamethasone alone and in combination with desipramine, phenytoin, valproic acid or levetiracetam interferes with 5-ALA-mediated PpIX production and cellular retention in glioblastoma cells.
Topics: Aminolevulinic Acid; Anti-Inflammatory Agents; Anticonvulsants; Desipramine; Dexamethasone; Drug The | 2016 |
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Combined M | 2016 |
Tunable phosphatase-sensitive stable prodrugs of 5-aminolevulinic acid for tumor fluorescence photodetection.
Topics: Alkaline Phosphatase; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Chick Embryo; | 2016 |
Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Syner | 2016 |
Minispectrometer with handheld probe for 5-ALA based fluorescence-guided surgery of brain tumors: Preliminary study for clinical applications.
Topics: Brain Neoplasms; Glioblastoma; Humans; Meningioma; Neurosurgical Procedures; Photosensitizing Agents | 2017 |
Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection.
Topics: Aged; Brain; Brain Neoplasms; Glioblastoma; Gliosarcoma; Humans; Image Interpretation, Computer-Assi | 2010 |
Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enz | 2011 |
Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.
Topics: Aminolevulinic Acid; Cell Death; Cell Line, Tumor; Glioblastoma; Humans; Hydroxymethylbilane Synthas | 2012 |
Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy.
Topics: Absorption; Algorithms; Aminolevulinic Acid; Brain Neoplasms; Computer Simulation; Finite Element An | 2011 |
Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced magnetic resonance image contrast but has higher diagnostic accuracy.
Topics: Aminolevulinic Acid; Animals; Area Under Curve; Cell Line, Tumor; Diffusion; Gadolinium; Glioblastom | 2011 |
Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Survival; | 2004 |
Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Astrocytes; Cells, Cultured; Fluorescence; Glioblastoma; Humans; Neuro | 2005 |
Relation between intracellular location and photodynamic efficacy of 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Comparison between human glioblastoma cells and other cancer cell lines.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Dose-Response Relationship | 2007 |
Cell-substrate topology upon ALA-PDT using variable-angle total internal reflection fluorescence microscopy (VA-TIRFM).
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Drug Screening Assays, Antitu | 2007 |
Protoporphyrin IX fluorescence kinetics in C6 glioblastoma cells after delta-aminolevulinic acid incubation: effect of a protoporphyrinogen oxidase inhibitor.
Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Fluorescence; Glioblastoma; Humans; Kinetics; Oxido | 1999 |
Photodynamic therapy of human glioma spheroids using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Glioblastoma; Humans; Microscopy, Fluorescence; Photochemotherapy; Protoporphyr | 2000 |