protoporphyrin ix has been researched along with Angioblastic Meningioma in 12 studies
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed." | 7.96 | Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020) |
| "We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)." | 7.88 | Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging. ( Brokinkel, B; Jeibmann, A; Karst, U; Kröger, S; Senner, V; Stummer, W, 2018) |
| "The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions." | 5.37 | Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011) |
| "OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination." | 5.27 | Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018) |
| " Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)." | 5.15 | Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011) |
| "Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas." | 4.85 | [Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009) |
| "Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse." | 4.02 | 5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021) |
| "The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed." | 3.96 | Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020) |
| "We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)." | 3.88 | Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging. ( Brokinkel, B; Jeibmann, A; Karst, U; Kröger, S; Senner, V; Stummer, W, 2018) |
| "(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection." | 3.79 | Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013) |
| "The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions." | 1.37 | Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kaneko, S | 1 |
| Brokinkel, B | 3 |
| Suero Molina, E | 1 |
| Warneke, N | 1 |
| Holling, M | 1 |
| Bunk, EC | 2 |
| Hess, K | 1 |
| Senner, V | 3 |
| Paulus, W | 1 |
| Stummer, W | 4 |
| Wagner, A | 1 |
| Roberts, DW | 5 |
| Olson, JD | 1 |
| Evans, LT | 1 |
| Kolste, KK | 1 |
| Kanick, SC | 1 |
| Fan, X | 2 |
| Bravo, JJ | 1 |
| Wilson, BC | 4 |
| Leblond, F | 4 |
| Marois, M | 1 |
| Paulsen, KD | 4 |
| Kröger, S | 1 |
| Jeibmann, A | 1 |
| Karst, U | 1 |
| Valdes, PA | 4 |
| Millesi, M | 1 |
| Widhalm, G | 1 |
| Masubuchi, T | 1 |
| Kajimoto, Y | 2 |
| Kawabata, S | 1 |
| Nonoguchi, N | 1 |
| Fujishiro, T | 1 |
| Miyatake, S | 2 |
| Kuroiwa, T | 2 |
| Bekelis, K | 2 |
| Harris, BT | 3 |
| Kim, A | 3 |
| Simmons, NE | 2 |
| Erkmen, K | 3 |
| Wilbers, E | 1 |
| Hargus, G | 1 |
| Wölfer, J | 1 |
| Cornelius, JF | 1 |
| Placke, JM | 1 |
| Knipps, J | 1 |
| Fischer, I | 1 |
| Kamp, M | 1 |
| Steiger, HJ | 1 |
| Tosteson, TD | 1 |
| Hartov, A | 1 |
| Ji, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488] | Phase 1 | 540 participants (Anticipated) | Interventional | 2014-07-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for protoporphyrin ix and Angioblastic Meningioma
| Article | Year |
|---|---|
5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningeal Neoplasms; Meningioma; Optical Imaging; Pro | 2019 |
[Intraoperative photo-dynamic diagnosis of brain tumors].
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat | 2009 |
2 trials available for protoporphyrin ix and Angioblastic Meningioma
| Article | Year |
|---|---|
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye | 2018 |
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl | 2011 |
8 other studies available for protoporphyrin ix and Angioblastic Meningioma
| Article | Year |
|---|---|
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; | 2020 |
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op | 2021 |
Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging.
Topics: Dura Mater; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Photosensitizing Agents; Pro | 2018 |
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R | 2013 |
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Cluster Analysis; Female; | 2014 |
Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Meningeal Neoplasms; Meningioma; Photosens | 2014 |
Minispectrometer with handheld probe for 5-ALA based fluorescence-guided surgery of brain tumors: Preliminary study for clinical applications.
Topics: Brain Neoplasms; Glioblastoma; Humans; Meningioma; Neurosurgical Procedures; Photosensitizing Agents | 2017 |
Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.
Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Humans; Meningeal Neoplasms; Meningioma; Middle Age | 2011 |