Page last updated: 2024-11-03

protoporphyrin ix and Angioblastic Meningioma

protoporphyrin ix has been researched along with Angioblastic Meningioma in 12 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Research Excerpts

ExcerptRelevanceReference
"The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed."7.96Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020)
"We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)."7.88Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging. ( Brokinkel, B; Jeibmann, A; Karst, U; Kröger, S; Senner, V; Stummer, W, 2018)
"The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions."5.37Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011)
"OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination."5.27Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018)
" Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)."5.15Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011)
"Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas."4.85[Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009)
"Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse."4.025-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021)
"The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed."3.96Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020)
"We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)."3.88Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging. ( Brokinkel, B; Jeibmann, A; Karst, U; Kröger, S; Senner, V; Stummer, W, 2018)
"(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection."3.79Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013)
"The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions."1.37Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's9 (75.00)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Kaneko, S1
Brokinkel, B3
Suero Molina, E1
Warneke, N1
Holling, M1
Bunk, EC2
Hess, K1
Senner, V3
Paulus, W1
Stummer, W4
Wagner, A1
Roberts, DW5
Olson, JD1
Evans, LT1
Kolste, KK1
Kanick, SC1
Fan, X2
Bravo, JJ1
Wilson, BC4
Leblond, F4
Marois, M1
Paulsen, KD4
Kröger, S1
Jeibmann, A1
Karst, U1
Valdes, PA4
Millesi, M1
Widhalm, G1
Masubuchi, T1
Kajimoto, Y2
Kawabata, S1
Nonoguchi, N1
Fujishiro, T1
Miyatake, S2
Kuroiwa, T2
Bekelis, K2
Harris, BT3
Kim, A3
Simmons, NE2
Erkmen, K3
Wilbers, E1
Hargus, G1
Wölfer, J1
Cornelius, JF1
Placke, JM1
Knipps, J1
Fischer, I1
Kamp, M1
Steiger, HJ1
Tosteson, TD1
Hartov, A1
Ji, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488]Phase 1540 participants (Anticipated)Interventional2014-07-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for protoporphyrin ix and Angioblastic Meningioma

ArticleYear
5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.
    Journal of neuro-oncology, 2019, Volume: 141, Issue:3

    Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningeal Neoplasms; Meningioma; Optical Imaging; Pro

2019
[Intraoperative photo-dynamic diagnosis of brain tumors].
    Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:7

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat

2009

Trials

2 trials available for protoporphyrin ix and Angioblastic Meningioma

ArticleYear
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
    Journal of neurosurgery, 2018, Volume: 128, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye

2018
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
    Journal of neurosurgery, 2011, Volume: 115, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl

2011

Other Studies

8 other studies available for protoporphyrin ix and Angioblastic Meningioma

ArticleYear
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
    Acta neurochirurgica, 2020, Volume: 162, Issue:9

    Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma;

2020
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
    Journal of neuro-oncology, 2021, Volume: 152, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op

2021
Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging.
    Acta neurochirurgica, 2018, Volume: 160, Issue:7

    Topics: Dura Mater; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Photosensitizing Agents; Pro

2018
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
    Photomedicine and laser surgery, 2013, Volume: 31, Issue:9

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R

2013
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.
    Neurosurgery, 2014, Volume: 10 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Cluster Analysis; Female;

2014
Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
    Acta neurochirurgica, 2014, Volume: 156, Issue:10

    Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Meningeal Neoplasms; Meningioma; Photosens

2014
Minispectrometer with handheld probe for 5-ALA based fluorescence-guided surgery of brain tumors: Preliminary study for clinical applications.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 17

    Topics: Brain Neoplasms; Glioblastoma; Humans; Meningioma; Neurosurgical Procedures; Photosensitizing Agents

2017
Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.
    Neurosurgical focus, 2011, Volume: 30, Issue:5

    Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Humans; Meningeal Neoplasms; Meningioma; Middle Age

2011