Page last updated: 2024-11-03

protoporphyrin ix and Actinic Keratosis

protoporphyrin ix has been researched along with Actinic Keratosis in 29 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Research Excerpts

ExcerptRelevanceReference
"Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment."9.20Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy. ( Chapman, MS; Davis, SC; Hasan, T; Kanick, SC; Maytin, EV; Pogue, BW; Sheehan, KL; Zhao, Y, 2015)
"Dosimetry for aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy of actinic keratosis was examined with an optimized fluorescence dosimeter to measure PpIX during treatment."7.80Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis. ( Chapman, MS; Davis, SC; Hasan, T; Kanick, SC; Maytin, EV; Pogue, BW; Zhao, Y, 2014)
"We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching."7.79Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy. ( Barge, J; Kasraee, B; Piffaretti, F; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2013)
" Protoporphyrin IX (PpIX) accumulation becomes lower after 3 h in pulse-PDT than in classical PDT, but pulse-PDT still has full treatment effect on actinic keratosis (AK)."5.27Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage. ( Bieliauskiene, G; Heerfordt, IM; Wulf, HC, 2018)
"Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment."5.20Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy. ( Chapman, MS; Davis, SC; Hasan, T; Kanick, SC; Maytin, EV; Pogue, BW; Sheehan, KL; Zhao, Y, 2015)
" Objective and visual erythema, protoporphyrin IX (PpIX) fluorescence and pain were evaluated."5.19Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial. ( Petersen, B; Wiegell, SR; Wulf, HC, 2014)
"Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) or its methyl ester (MAL) is a very effective method to treat actinic keratosis (AK)."4.85New aspects in photodynamic therapy of actinic keratoses. ( Moor, AC; Smits, T, 2009)
"Dosimetry for aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy of actinic keratosis was examined with an optimized fluorescence dosimeter to measure PpIX during treatment."3.80Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis. ( Chapman, MS; Davis, SC; Hasan, T; Kanick, SC; Maytin, EV; Pogue, BW; Zhao, Y, 2014)
"We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching."3.79Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy. ( Barge, J; Kasraee, B; Piffaretti, F; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2013)
"Because of the retrospective study design not all factors that may influence pain (eg, protoporphyrin IX fluorescence) were recorded."3.76Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses. ( Denk, K; Enk, A; Gholam, P; Hartmann, M; Sehr, T, 2010)
"Pain is the main acute adverse event during photodynamic therapy of skin lesions."2.74Cold water and pauses in illumination reduces pain during photodynamic therapy: a randomized clinical study. ( Haedersdal, M; Wiegell, SR; Wulf, HC, 2009)
" Protoporphyrin IX synthesis and photobleaching kinetics allow monitoring clinical PDT which facilitates individual-based PDT dosing and improvement of clinical treatment protocols."1.42Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy. ( Amelink, A; Hoy, CL; Middelburg, TA; Neumann, HA; Robinson, DJ, 2015)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (10.34)29.6817
2010's25 (86.21)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Ruiz, AJ2
Allen, R1
Giallorenzi, MK1
Samkoe, KS1
Shane Chapman, M1
Pogue, BW4
LaRochelle, EPM1
Gunn, JR1
Hull, SM1
Hasan, T3
Chapman, MS3
Manley, M2
Collins, P2
Gray, L2
O'Gorman, S1
McCavana, J2
Maytin, EV3
Anand, S1
Riha, M1
Lohser, S1
Tellez, A1
Ishak, R1
Karpinski, L1
Sot, J1
Hu, B1
Denisyuk, A1
Davis, SC3
Kyei, A1
Vidimos, A1
Heerfordt, IM2
Bieliauskiene, G1
Wulf, HC7
McLellan, LJ1
O'Mahoney, P1
Khazova, M1
Higlett, M1
Ibbotson, SH2
Eadie, E1
Piffaretti, F1
Zellweger, M1
Kasraee, B1
Barge, J1
Salomon, D1
van den Bergh, H1
Wagnières, G1
Petersen, B3
Wiegell, SR6
Kanick, SC2
Zhao, Y2
Middelburg, TA1
Hoy, CL1
Neumann, HA2
Amelink, A1
Robinson, DJ1
Salas-García, T1
López-Gómez, A1
Dorado-Fernández, M1
Ruiz-Martínez, J1
Kulyk, O1
Moseley, H1
Valentine, RM1
Samuel, ID1
Sheehan, KL1
O'Gorman, SM1
Clowry, J1
Kavanagh, A1
Lally, A1
Chen, J1
Zhang, Y1
Wang, P1
Wang, B1
Zhang, G1
Wang, X1
Nissen, CV1
Mikkelsen, CS1
Ibbotson, S1
Stones, R1
Bowling, J1
Campbell, S2
Kownacki, S1
Sivaramakrishnan, M1
Valentine, R1
Morton, CA1
Gandy, J1
Labadie, B1
Bierman, D1
Zachary, C1
Smits, T2
van Laarhoven, AI1
Staassen, A1
van de Kerkhof, PC1
van Erp, PE1
Gerritsen, MJ1
Haedersdal, M1
Moor, AC1
Tyrrell, J1
Curnow, A3
Gholam, P1
Denk, K1
Sehr, T1
Enk, A1
Hartmann, M1
Tyrrell, JS1
Morton, C1
Campbell, SM1
van der Beek, N1
de Leeuw, J1
Demmendal, C1
Bjerring, P1
Fabricius, S1
Heydenreich, J1
Enk, CD1
Rosso, S1
Bäumler, W1
Baldursson, BT1
Blake, E1
Allen, J1
Thorn, C1
Shore, A1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737]43 participants (Actual)Interventional2019-11-01Completed
Portable Measurement of Protoporphyrin IX in the Skin[NCT04223570]218 participants (Anticipated)Observational2022-12-01Enrolling by invitation
Fluorescence and Thermal Imaging of the Skin Before and During Photodynamic Therapy[NCT03167762]18 participants (Actual)Interventional2017-06-22Completed
[NCT02520700]22 participants (Actual)Interventional2013-09-30Completed
The Study of Plum-blossom Needling Enhancing Efficacy of Aminolevulinic Acid-photodynamic Therapy for Actinic Keratosis: a Randomized and Multi-center Clinical Trial[NCT03596619]250 participants (Anticipated)Interventional2018-08-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for protoporphyrin ix and Actinic Keratosis

ArticleYear
Daylight photodynamic therapy.
    Actas dermo-sifiliograficas, 2015, Volume: 106, Issue:8

    Topics: Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Meteorological Concepts; Photochemotherapy; Photo

2015
New aspects in photodynamic therapy of actinic keratoses.
    Journal of photochemistry and photobiology. B, Biology, 2009, Sep-04, Volume: 96, Issue:3

    Topics: Aminolevulinic Acid; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Protopo

2009

Trials

13 trials available for protoporphyrin ix and Actinic Keratosis

ArticleYear
5-Fluorouracil Enhances Protoporphyrin IX Accumulation and Lesion Clearance during Photodynamic Therapy of Actinic Keratoses: A Mechanism-Based Clinical Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 07-01, Volume: 24, Issue:13

    Topics: Apoptosis; Biomarkers; Biopsy; Fluorouracil; Heme; Humans; Keratosis, Actinic; Photochemotherapy; Ph

2018
Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 22

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Face; Female; Humans; Keratosis, Actinic; M

2018
Light protection of the skin after photodynamic therapy reduces inflammation: an unblinded randomized controlled study.
    The British journal of dermatology, 2014, Volume: 171, Issue:1

    Topics: Aminolevulinic Acid; Drug Eruptions; Erythema; Female; Fluorescence; Humans; Keratosis, Actinic; Mal

2014
Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial.
    The British journal of dermatology, 2014, Volume: 171, Issue:6

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; C

2014
Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Optical Imaging; Photosensit

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratos

2015
Artificial White Light vs Daylight Photodynamic Therapy for Actinic Keratoses: A Randomized Clinical Trial.
    JAMA dermatology, 2016, 06-01, Volume: 152, Issue:6

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Facial Dermatoses; Follow-Up Studies; Humans; Keratosi

2016
Pulse photodynamic therapy reduces inflammation without compromising efficacy in the treatment of multiple mild actinic keratoses of the face and scalp: a randomized clinical trial.
    The British journal of dermatology, 2016, Volume: 174, Issue:5

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Erythema; Facial Dermatoses; Female; Fluorescence; Hum

2016
Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis: a randomized controlled trial.
    The British journal of dermatology, 2017, Volume: 176, Issue:5

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Drug Eruptions; Erythema; Female; Fluoresce

2017
Cold water and pauses in illumination reduces pain during photodynamic therapy: a randomized clinical study.
    Acta dermato-venereologica, 2009, Volume: 89, Issue:2

    Topics: Aged; Cold Temperature; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; P

2009
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
    The British journal of dermatology, 2011, Volume: 164, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo

2011
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
    The British journal of dermatology, 2011, Volume: 164, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo

2011
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
    The British journal of dermatology, 2011, Volume: 164, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo

2011
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
    The British journal of dermatology, 2011, Volume: 164, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluo

2011
PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: an intra-patient direct comparison study.
    Lasers in surgery and medicine, 2012, Volume: 44, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Bowen's Disease; Carcinoma; Carcinoma, Basal Cell; False Neg

2012
Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
    Lasers in medical science, 2013, Volume: 28, Issue:3

    Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Oxygen; Pho

2013

Other Studies

14 other studies available for protoporphyrin ix and Actinic Keratosis

ArticleYear
Smartphone-based dual radiometric fluorescence and white-light imager for quantification of protoporphyrin IX in skin.
    Journal of biomedical optics, 2023, Volume: 28, Issue:8

    Topics: Humans; Keratosis, Actinic; Light; Skin; Smartphone

2023
Smartphone fluorescence imager for quantitative dosimetry of protoporphyrin-IX-based photodynamic therapy in skin.
    Journal of biomedical optics, 2019, Volume: 25, Issue:6

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Equipment Design; Humans; Imaging, Three-Di

2019
Quantifying the radiant exposure and effective dose in patients treated for actinic keratoses with topical photodynamic therapy using daylight and LED white light.
    Physics in medicine and biology, 2018, 01-26, Volume: 63, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Humans; Keratosis, Actinic; Light; Lighting; Male; Pho

2018
Ultraviolet radiation exposure during daylight Photodynamic Therapy.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 27

    Topics: Dose-Response Relationship, Drug; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Ag

2019
Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy.
    Dermatology (Basel, Switzerland), 2013, Volume: 227, Issue:3

    Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Keratosis, Actinic; Middle Aged; Pain; Pain Measure

2013
Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis.
    Journal of biomedical optics, 2014, Volume: 19, Issue:7

    Topics: Humans; Keratosis, Actinic; Phantoms, Imaging; Photochemotherapy; Pilot Projects; Protoporphyrins; R

2014
Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis.
    Journal of biomedical optics, 2014, Volume: 19, Issue:7

    Topics: Humans; Keratosis, Actinic; Phantoms, Imaging; Photochemotherapy; Pilot Projects; Protoporphyrins; R

2014
Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis.
    Journal of biomedical optics, 2014, Volume: 19, Issue:7

    Topics: Humans; Keratosis, Actinic; Phantoms, Imaging; Photochemotherapy; Pilot Projects; Protoporphyrins; R

2014
Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis.
    Journal of biomedical optics, 2014, Volume: 19, Issue:7

    Topics: Humans; Keratosis, Actinic; Phantoms, Imaging; Photochemotherapy; Pilot Projects; Protoporphyrins; R

2014
Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy.
    Journal of dermatological science, 2015, Volume: 79, Issue:1

    Topics: Aged; Female; Fiber Optic Technology; Fluorescence; Humans; Keratosis, Actinic; Male; Optical Imagin

2015
Plum-blossom needling promoted PpIX fluorescence intensity from 5-aminolevulinic acid in porcine skin model and patients with actnic keratosis.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 15

    Topics: Acupuncture Therapy; Aged; Aminolevulinic Acid; Animals; Female; Fluorescent Dyes; Humans; In Vitro

2016
A consensus on the use of daylight photodynamic therapy in the UK.
    The Journal of dermatological treatment, 2017, Volume: 28, Issue:4

    Topics: Aminolevulinic Acid; Consensus; Humans; Keratosis, Actinic; Light; Male; Photochemotherapy; Photosen

2017
Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time.
    Journal of drugs in dermatology : JDD, 2017, Mar-01, Volume: 16, Issue:3

    Topics: Aminolevulinic Acid; Face; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Photochemotherapy; P

2017
Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells.
    The British journal of dermatology, 2009, Volume: 160, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Humans; Keratosis, Actinic; Photochemotherapy; Photose

2009
Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT.
    Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:2

    Topics: Aged; Aminolevulinic Acid; Dose-Response Relationship, Drug; Fluorescence; Humans; Keratosis, Actini

2010
Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses.
    Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cosmetic Techniques; Female; Humans; Keratosis,

2010
Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin IX-weighted daylight doses measured in six geographical locations.
    The British journal of dermatology, 2013, Volume: 168, Issue:1

    Topics: Aminolevulinic Acid; Dose-Response Relationship, Radiation; Europe; Geography, Medical; Humans; Isra

2013