protocatechuic acid has been researched along with Parkinson Disease in 3 studies
protocatechuic acid: RN given refers to parent cpd; structure
3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, T | 1 |
| Fang, X | 1 |
| Xu, J | 1 |
| Jiang, Y | 1 |
| Cao, F | 1 |
| Zhao, L | 1 |
| Zhang, Z | 1 |
| Li, G | 1 |
| Szeto, SSW | 1 |
| Chong, CM | 1 |
| Quan, Q | 1 |
| Huang, C | 1 |
| Cui, W | 1 |
| Guo, B | 1 |
| Wang, Y | 1 |
| Han, Y | 1 |
| Michael Siu, KW | 1 |
| Yuen Lee, SM | 1 |
| Chu, IK | 1 |
| Ste-Marie, L | 1 |
| Vachon, L | 1 |
| Bémeur, C | 1 |
| Lambert, J | 1 |
| Montgomery, J | 1 |
3 other studies available for protocatechuic acid and Parkinson Disease
| Article | Year |
|---|---|
Synergistic Effects of Ginkgolide B and Protocatechuic Acid on the Treatment of Parkinson's Disease.
Topics: Animals; Apoptosis; Biomarkers; Cell Survival; Disease Models, Animal; Drug Synergism; Gene Expressi | 2020 |
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease.
Topics: Animals; Antiparkinson Agents; Dopaminergic Neurons; Drug Evaluation, Preclinical; Flavonoids; Heme | 2015 |
Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate.
Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Antioxidants; Butylamines; Corpus Striatum; D | 1999 |