protocatechuic acid has been researched along with Disease Models, Animal in 47 studies
protocatechuic acid: RN given refers to parent cpd; structure
3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS." | 7.85 | Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway. ( Almar, M; Crespo, I; González-Gallego, J; Mauriz, JL; Ortiz de Urbina, JJ; San-Miguel, B; Tuñón, MJ, 2017) |
| "The study aims to investigate the effects of protocatechuic acid (PCA) separated from Chinese herbs, on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice." | 7.81 | Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways. ( Guan, S; Li, C; Li, J; Xu, Y; Zhang, X; Zhao, M, 2015) |
| "Protocatechuic acid (PCA) is a natural component with multiple biological activities." | 5.91 | Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis. ( Hu, S; Li, L; Sun, X; Tan, Y; Xiao, S; Yang, X; Zhong, L; Zhou, F; Zhou, Z, 2023) |
| "Protocatechuic acid (PCA) is a phenolic acid been proved neuroprotection in ICH without understanding of details." | 5.62 | Protocatechuic Acid Suppresses Microglia Activation and Facilitates M1 to M2 Phenotype Switching in Intracerebral Hemorrhage Mice. ( Bian, L; Chen, X; Sun, Q; Sun, Y; Wang, B; Xi, Z; Xu, C; Zhong, Z, 2021) |
| "Protocatechuic acid has antioxidant activity." | 5.32 | Protective effect of protocatechuic acid isopropyl ester against murine models of sepsis: inhibition of TNF-alpha and nitric oxide production and augmentation of IL-10. ( Hong, YJ; Jung, JS; Kim, YH; Moon, YS; Song, DK; Suh, HW; Yan, JJ; Yun-Choi, HS, 2004) |
| "Pretreatment with protocatechuic acid isopropyl ester effectively suppressed the LPS/GalN-induced increase in plasma tumor necrosis factor (TNF)-alpha alanine aminotransferase (ALT), nitrite/nitrate levels, and hepatic malondialdehyde levels." | 5.32 | Protective effect of protocatechuic acid isopropyl ester against murine models of sepsis: inhibition of TNF-alpha and nitric oxide production and augmentation of IL-10. ( Hong, YJ; Jung, JS; Kim, YH; Moon, YS; Song, DK; Suh, HW; Yan, JJ; Yun-Choi, HS, 2004) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " staudtii stem bark, as well as protocatechuic acid and betulinic acid isolated from the bioactive ethyl acetate fraction were evaluated in different mice models of inflammation and pain; furthermore, antioxidant assays were carried out." | 4.02 | Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark. ( Ajibesin, K; Akpan, O; Archibong, B; De Leo, M; Eseyin, O; Essien, E; Etukudo, E; Flamini, G; Thomas, P; Udoh, A, 2021) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "It is aimed to investigate the possible contribution of cannabinoid system that supresses the nociceptive process by the activation of CB1 and CB2 receptors in central and peripheral levels of pain pathways, to the analgesic activity of protocatechuic acid." | 3.91 | Cannabinoid system involves in the analgesic effect of protocatechuic acid. ( Arslan, R; Bektas, N; Dikmen, DY; Okcay, Y, 2019) |
| "(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS." | 3.85 | Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway. ( Almar, M; Crespo, I; González-Gallego, J; Mauriz, JL; Ortiz de Urbina, JJ; San-Miguel, B; Tuñón, MJ, 2017) |
| "The study aims to investigate the effects of protocatechuic acid (PCA) separated from Chinese herbs, on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice." | 3.81 | Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways. ( Guan, S; Li, C; Li, J; Xu, Y; Zhang, X; Zhao, M, 2015) |
| "Protocatechuic acid (PCA) is a natural component with multiple biological activities." | 1.91 | Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis. ( Hu, S; Li, L; Sun, X; Tan, Y; Xiao, S; Yang, X; Zhong, L; Zhou, F; Zhou, Z, 2023) |
| "Post-traumatic stress disorder (PTSD) is a serious psychiatric disorder characterized by impaired fear extinction, depression, and anxiety caused by dysregulation of the hypothalamic-pituitary-adrenal axis and an imbalance of monoamines." | 1.72 | The Anxiolytic-Like Effects of Protocatechuic Acid in an Animal Model of Post-Traumatic Stress Disorder. ( Hahm, DH; Kwon, S; Lee, B; Sur, B, 2022) |
| "Protocatechuic acid (PCA) is a biological agent with multiple functions." | 1.72 | Protocatechuic acid protects mice from influenza A virus infection. ( Li, H; Li, Z; Ren, X; Wang, Q; Wang, X; Wu, J; Yang, L; Zhang, Y, 2022) |
| "Protocatechuic acid (PCA) is a phenolic acid been proved neuroprotection in ICH without understanding of details." | 1.62 | Protocatechuic Acid Suppresses Microglia Activation and Facilitates M1 to M2 Phenotype Switching in Intracerebral Hemorrhage Mice. ( Bian, L; Chen, X; Sun, Q; Sun, Y; Wang, B; Xi, Z; Xu, C; Zhong, Z, 2021) |
| "Focal ischemia was induced by middle cerebral artery occlusion in adult male Wistar rats and confirmed by measuring infarction of brain by 2,3,5-Triphenyltetrazolium chloride (TTC) staining." | 1.62 | Protocatechuic Acid Prevents Early Hour Ischemic Reperfusion Brain Damage by Restoring Imbalance of Neuronal Cell Death and Survival Proteins. ( Ambulkar, S; Kale, S; Kharat, A; Prakash, A; Sakharkar, AJ; Sarode, LP; Ugale, RR, 2021) |
| "Furthermore, PCA reduced astrogliosis and microgliosis in spinal cord, protected spinal motor neurons from apoptosis, and maintained neuromuscular junction integrity in transgenic mice." | 1.56 | Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1 ( Baybayon-Grandgeorge, AN; Holsopple, J; Koza, LA; Linseman, DA; Mazzarino, RC; Olson, JR; Patterson, D; Pena, C; Winter, AN, 2020) |
| "Protocatechuic acid (PCA) is a phenolic acid metabolite of the parent anthocyanin, kuromanin, found in blackberries and bilberries." | 1.56 | Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1 ( Baybayon-Grandgeorge, AN; Holsopple, J; Koza, LA; Linseman, DA; Mazzarino, RC; Olson, JR; Patterson, D; Pena, C; Winter, AN, 2020) |
| "Insulin resistance was induced in male Wistar rats by a 7-day treatment with dexamethasone (DEX) (1 mg/kg/day, i." | 1.51 | Protocatechuic acid exhibits hepatoprotective, vasculoprotective, antioxidant and insulin-like effects in dexamethasone-induced insulin-resistant rats. ( El-Sonbaty, YA; Gameil, NM; Megahed, N; Suddek, GM, 2019) |
| " Memory impairment was induced by long-term administration of D-Gal (100 mg/kg body weight/day) directly via oral gavage." | 1.51 | Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment. ( Blecharz-Klin, K; Joniec-Maciejak, I; Krzysztoforska, K; Mirowska-Guzel, D; Piechal, A; Pyrzanowska, J; Widy-Tyszkiewicz, E, 2019) |
| "Protocatechuic acid (PCA) is a phenolic compound believed to have neuroprotective and procognitive activity." | 1.51 | Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment. ( Blecharz-Klin, K; Joniec-Maciejak, I; Krzysztoforska, K; Mirowska-Guzel, D; Piechal, A; Pyrzanowska, J; Widy-Tyszkiewicz, E, 2019) |
| "Protocatechuic acid (PCA) has been well studied for its neuroprotection value in several diseases, but the effect in intracerebral haemorrhage (ICH) has not been reported." | 1.51 | Protocatechuic acid exerts protective effects via suppression of the P38/JNK- NF-κB signalling pathway in an experimental mouse model of intracerebral haemorrhage. ( Bian, L; Chen, X; Hu, X; Ren, J; Sun, Q; Sun, Y; Wang, B; Xi, Z; Yang, GY; Yang, Y; Zhong, Z, 2019) |
| "Protocatechuic acid is an antioxidant which is shown to have analgesic activity in limited studies." | 1.51 | Cannabinoid system involves in the analgesic effect of protocatechuic acid. ( Arslan, R; Bektas, N; Dikmen, DY; Okcay, Y, 2019) |
| "d-Galactose (D-Gal) is a sugar, which administered to mammals can induce cognitive deficits." | 1.51 | Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment. ( Blecharz-Klin, K; Joniec-Maciejak, I; Krzysztoforska, K; Mirowska-Guzel, D; Piechal, A; Pyrzanowska, J; Widy-Tyszkiewicz, E, 2019) |
| "Protocatechuic acid (PCA) is a natural antioxidant with beneficial cardiovascular properties." | 1.48 | Antihypertensive and antioxidant effects of protocatechuic acid in deoxycorticosterone acetate-salt hypertensive rats. ( Emami, R; Haghighatian, Z; Hajhashemi, V; Safaeian, L, 2018) |
| "Protocatechuic acid (PCA) was first purified from green tea and has shown numerous biological activities, including anti-apoptotic, anti-inflammatory, and anti-atherosclerotic effects." | 1.46 | Administration of Protocatechuic Acid Reduces Traumatic Brain Injury-Induced Neuronal Death. ( Choi, BY; Hong, DK; Jeong, JH; Kho, AR; Lee, SH; Suh, SW, 2017) |
| "Protocatechuic acid was the main phenolic compound found in ASF, followed by kaempferide and vanillic acid." | 1.38 | Hypolipidemic effect of avocado (Persea americana Mill) seed in a hypercholesterolemic mouse model. ( Chamorro-Cevallos, G; Garduño-Siciliano, L; Hernández-Navarro, MD; Hernández-Ortega, M; Necoechea-Mondragón, H; Ortiz-Moreno, A; Pahua-Ramos, ME, 2012) |
| "Bleeding is the most common and serious adverse effect of currently available antiplatelet drugs." | 1.38 | Novel antiplatelet activity of protocatechuic acid through the inhibition of high shear stress-induced platelet aggregation. ( Bae, ON; Chung, JH; Chung, KY; Kang, S; Kim, K; Lim, KM; Noh, JY, 2012) |
| "5 mmol/kg dosed by gavage) for 5 days significantly decreased the serum levels of the hepatic enzyme markers alanine- and aspartate aminotransferase (ALT, alanine aminotransferase; AST, aspartate aminotransferase) induced by the 6-h treatment with LPS (i." | 1.32 | Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage. ( Cheng, MT; Chou, FP; Hsieh, YJ; Lin, WL; Tseng, TH; Wang, CJ, 2003) |
| "Pretreatment with protocatechuic acid isopropyl ester effectively suppressed the LPS/GalN-induced increase in plasma tumor necrosis factor (TNF)-alpha alanine aminotransferase (ALT), nitrite/nitrate levels, and hepatic malondialdehyde levels." | 1.32 | Protective effect of protocatechuic acid isopropyl ester against murine models of sepsis: inhibition of TNF-alpha and nitric oxide production and augmentation of IL-10. ( Hong, YJ; Jung, JS; Kim, YH; Moon, YS; Song, DK; Suh, HW; Yan, JJ; Yun-Choi, HS, 2004) |
| "Protocatechuic acid has antioxidant activity." | 1.32 | Protective effect of protocatechuic acid isopropyl ester against murine models of sepsis: inhibition of TNF-alpha and nitric oxide production and augmentation of IL-10. ( Hong, YJ; Jung, JS; Kim, YH; Moon, YS; Song, DK; Suh, HW; Yan, JJ; Yun-Choi, HS, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (8.51) | 29.6817 |
| 2010's | 24 (51.06) | 24.3611 |
| 2020's | 19 (40.43) | 2.80 |
| Authors | Studies |
|---|---|
| Fulas, OA | 1 |
| Laferrière, A | 1 |
| Coderre, TJ | 1 |
| Song, HK | 1 |
| Park, SH | 1 |
| Kim, HJ | 1 |
| Jang, S | 1 |
| Kim, T | 1 |
| Li, H | 2 |
| Zheng, T | 1 |
| Lian, F | 1 |
| Xu, T | 1 |
| Yin, W | 1 |
| Jiang, Y | 2 |
| Wang, Q | 1 |
| Ren, X | 1 |
| Wu, J | 1 |
| Yang, L | 1 |
| Zhang, Y | 2 |
| Wang, X | 2 |
| Li, Z | 1 |
| Sur, B | 1 |
| Kwon, S | 1 |
| Hahm, DH | 1 |
| Lee, B | 1 |
| Yang, X | 1 |
| Sun, X | 1 |
| Zhou, F | 1 |
| Xiao, S | 1 |
| Zhong, L | 1 |
| Hu, S | 1 |
| Zhou, Z | 1 |
| Li, L | 2 |
| Tan, Y | 1 |
| El-Sonbaty, YA | 1 |
| Suddek, GM | 1 |
| Megahed, N | 1 |
| Gameil, NM | 1 |
| Zheng, J | 1 |
| Li, Q | 1 |
| He, L | 1 |
| Weng, H | 1 |
| Su, D | 1 |
| Liu, X | 1 |
| Ling, W | 2 |
| Wang, D | 2 |
| Anderson, K | 1 |
| Ryan, N | 1 |
| Siddiqui, A | 1 |
| Pero, T | 1 |
| Volpedo, G | 1 |
| Cooperstone, JL | 1 |
| Oghumu, S | 1 |
| Koza, LA | 1 |
| Winter, AN | 1 |
| Holsopple, J | 1 |
| Baybayon-Grandgeorge, AN | 1 |
| Pena, C | 1 |
| Olson, JR | 1 |
| Mazzarino, RC | 1 |
| Patterson, D | 1 |
| Linseman, DA | 1 |
| Choi, JR | 1 |
| Kim, JH | 1 |
| Lee, S | 1 |
| Cho, EJ | 1 |
| Kim, HY | 1 |
| Wu, T | 1 |
| Fang, X | 1 |
| Xu, J | 1 |
| Cao, F | 1 |
| Zhao, L | 1 |
| Gouveia, BB | 1 |
| Barberino, RS | 1 |
| Dos Santos Silva, RL | 1 |
| Lins, TLBG | 1 |
| da Silva Guimarães, V | 1 |
| do Monte, APO | 1 |
| Palheta, RC | 1 |
| de Matos, MHT | 1 |
| Kale, S | 1 |
| Sarode, LP | 1 |
| Kharat, A | 1 |
| Ambulkar, S | 1 |
| Prakash, A | 1 |
| Sakharkar, AJ | 1 |
| Ugale, RR | 1 |
| Thomas, P | 1 |
| Essien, E | 1 |
| Udoh, A | 1 |
| Archibong, B | 1 |
| Akpan, O | 1 |
| Etukudo, E | 1 |
| De Leo, M | 1 |
| Eseyin, O | 1 |
| Flamini, G | 1 |
| Ajibesin, K | 1 |
| Thakare, VN | 2 |
| Lakade, SH | 1 |
| Mahajan, MP | 1 |
| Kulkarni, YP | 1 |
| Dhakane, VD | 2 |
| Harde, MT | 1 |
| Patel, BM | 2 |
| Xi, Z | 2 |
| Xu, C | 1 |
| Chen, X | 2 |
| Wang, B | 3 |
| Zhong, Z | 2 |
| Sun, Q | 2 |
| Sun, Y | 2 |
| Bian, L | 2 |
| Abdelmageed, ME | 1 |
| Nader, MA | 1 |
| Zaghloul, MS | 1 |
| Lee, SH | 2 |
| Choi, BY | 1 |
| Kho, AR | 1 |
| Jeong, JH | 1 |
| Hong, DK | 1 |
| Suh, SW | 1 |
| Safaeian, L | 1 |
| Emami, R | 1 |
| Hajhashemi, V | 1 |
| Haghighatian, Z | 1 |
| Ibitoye, OB | 1 |
| Ajiboye, TO | 1 |
| Patil, RR | 2 |
| Suralkar, AA | 1 |
| Hu, X | 1 |
| Yang, Y | 1 |
| Ren, J | 1 |
| Yang, GY | 1 |
| Krzysztoforska, K | 1 |
| Piechal, A | 1 |
| Blecharz-Klin, K | 1 |
| Pyrzanowska, J | 1 |
| Joniec-Maciejak, I | 1 |
| Mirowska-Guzel, D | 1 |
| Widy-Tyszkiewicz, E | 1 |
| Gani, SA | 1 |
| Muhammad, SA | 1 |
| Kura, AU | 1 |
| Barahuie, F | 1 |
| Hussein, MZ | 1 |
| Fakurazi, S | 1 |
| Owumi, SE | 1 |
| Ochaoga, SE | 1 |
| Odunola, OA | 1 |
| Farombi, EO | 1 |
| Molehin, OR | 1 |
| Adeyanju, AA | 1 |
| Adefegha, SA | 1 |
| Oyeyemi, AO | 1 |
| Idowu, KA | 1 |
| Dikmen, DY | 1 |
| Okcay, Y | 1 |
| Arslan, R | 1 |
| Bektas, N | 1 |
| Deng, JS | 1 |
| Lee, SD | 1 |
| Kuo, WW | 1 |
| Fan, MJ | 1 |
| Lin, YM | 1 |
| Hu, WS | 1 |
| Huang, YC | 1 |
| Velmurugan, BK | 1 |
| Tsai, FJ | 1 |
| Tsai, CH | 1 |
| Huang, CY | 2 |
| Tang, XL | 1 |
| Liu, JX | 1 |
| Dong, W | 1 |
| Li, P | 1 |
| Lin, CR | 1 |
| Zheng, YQ | 1 |
| Cong, WH | 1 |
| Hou, JC | 1 |
| Ou, C | 1 |
| Shi, N | 1 |
| Yang, Q | 1 |
| Wu, Z | 1 |
| Compans, RW | 1 |
| He, C | 1 |
| Zhang, X | 2 |
| Li, C | 2 |
| Li, J | 1 |
| Xu, Y | 1 |
| Guan, S | 1 |
| Zhao, M | 1 |
| Semaming, Y | 1 |
| Sripetchwandee, J | 1 |
| Sa-Nguanmoo, P | 1 |
| Pintana, H | 1 |
| Pannangpetch, P | 1 |
| Chattipakorn, N | 1 |
| Chattipakorn, SC | 1 |
| Yin, X | 1 |
| Lv, C | 1 |
| Yu, Y | 1 |
| Han, F | 1 |
| Crespo, I | 1 |
| San-Miguel, B | 1 |
| Mauriz, JL | 1 |
| Ortiz de Urbina, JJ | 1 |
| Almar, M | 1 |
| Tuñón, MJ | 1 |
| González-Gallego, J | 1 |
| Lin, CY | 1 |
| Huang, CS | 1 |
| Yin, MC | 1 |
| Zhang, HN | 2 |
| An, CN | 1 |
| Pu, XP | 1 |
| Loarca-Piña, G | 1 |
| Mendoza, S | 1 |
| Ramos-Gómez, M | 1 |
| Reynoso, R | 1 |
| Wei, X | 1 |
| Yan, X | 1 |
| Jin, T | 1 |
| Lende, AB | 1 |
| Kshirsagar, AD | 1 |
| Deshpande, AD | 1 |
| Muley, MM | 1 |
| Bafna, PA | 1 |
| Naik, SR | 1 |
| Pahua-Ramos, ME | 1 |
| Ortiz-Moreno, A | 1 |
| Chamorro-Cevallos, G | 1 |
| Hernández-Navarro, MD | 1 |
| Garduño-Siciliano, L | 1 |
| Necoechea-Mondragón, H | 1 |
| Hernández-Ortega, M | 1 |
| Kim, K | 1 |
| Bae, ON | 1 |
| Lim, KM | 1 |
| Noh, JY | 1 |
| Kang, S | 1 |
| Chung, KY | 1 |
| Chung, JH | 1 |
| Wang, GZ | 1 |
| Yao, JH | 1 |
| Jing, HR | 1 |
| Zhang, F | 1 |
| Lin, MS | 1 |
| Shi, L | 1 |
| Wu, H | 1 |
| Gao, DY | 1 |
| Liu, KX | 1 |
| Tian, XF | 1 |
| Lin, WL | 1 |
| Hsieh, YJ | 1 |
| Chou, FP | 1 |
| Wang, CJ | 1 |
| Cheng, MT | 1 |
| Tseng, TH | 1 |
| Yan, JJ | 1 |
| Jung, JS | 1 |
| Hong, YJ | 1 |
| Moon, YS | 1 |
| Suh, HW | 1 |
| Kim, YH | 1 |
| Yun-Choi, HS | 1 |
| Song, DK | 1 |
| Ste-Marie, L | 1 |
| Vachon, P | 1 |
| Vachon, L | 1 |
| Bémeur, C | 1 |
| Guertin, MC | 1 |
| Montgomery, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Consumption of a Beverage of Chaya (Cnidoscolus Chayamansa) on Lipid Concentration, Lipid Peroxidation and Antioxidant Status of Patients With Dyslipidemia[NCT04110392] | 30 participants (Actual) | Interventional | 2019-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for protocatechuic acid and Disease Models, Animal
1 trial available for protocatechuic acid and Disease Models, Animal
46 other studies available for protocatechuic acid and Disease Models, Animal
| Article | Year |
|---|---|
Novel Co-crystal of Pentoxifylline and Protocatechuic Acid Relieves Allodynia in Rat Models of Peripheral Neuropathic Pain and CRPS by Alleviating Local Tissue Hypoxia.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Hydroxybenzoates; Hyperalgesia; Hy | 2021 |
Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production.
Topics: Alpinia; Animals; Anti-Inflammatory Agents; Antigens, Dermatophagoides; Arthropod Proteins; Catechin | 2021 |
Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthocyanins; Autophagy; Blueberry Plants; Diseas | 2022 |
Protocatechuic acid protects mice from influenza A virus infection.
Topics: Animals; Disease Models, Animal; Hydroxybenzoates; Influenza A Virus, H1N1 Subtype; Mice; Mice, Inbr | 2022 |
The Anxiolytic-Like Effects of Protocatechuic Acid in an Animal Model of Post-Traumatic Stress Disorder.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Disease Models, Animal; Extinction, Psychologic | 2022 |
Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis.
Topics: Animals; Caco-2 Cells; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Dextrans; Disease Model | 2023 |
Protocatechuic acid exhibits hepatoprotective, vasculoprotective, antioxidant and insulin-like effects in dexamethasone-induced insulin-resistant rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Dietary Supplements; Disease Models, Animal; Dyslipidemia | 2019 |
Protocatechuic Acid Inhibits Vulnerable Atherosclerotic Lesion Progression in Older Apoe-/- Mice.
Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; c-Mer Tyrosine Kinase; Cells, | 2020 |
Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses.
Topics: Animals; B7-1 Antigen; Dendritic Cells; Dermatitis, Contact; Dietary Supplements; Dinitrofluorobenze | 2020 |
Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1
Topics: Amyotrophic Lateral Sclerosis; Animals; Anticarcinogenic Agents; Disease Models, Animal; Gliosis; Hy | 2020 |
Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition Disorders; Disease Models, Animal; Huma | 2020 |
Synergistic Effects of Ginkgolide B and Protocatechuic Acid on the Treatment of Parkinson's Disease.
Topics: Animals; Apoptosis; Biomarkers; Cell Survival; Disease Models, Animal; Drug Synergism; Gene Expressi | 2020 |
Involvement of PTEN and FOXO3a Proteins in the Protective Activity of Protocatechuic Acid Against Cisplatin-Induced Ovarian Toxicity in Mice.
Topics: Animals; Apoptosis; Cell Proliferation; Cisplatin; Disease Models, Animal; Female; Forkhead Box Prot | 2021 |
Protocatechuic Acid Prevents Early Hour Ischemic Reperfusion Brain Damage by Restoring Imbalance of Neuronal Cell Death and Survival Proteins.
Topics: Animals; Apoptosis; Brain; Caspase 3; Cyclic AMP Response Element-Binding Protein; Disease Models, A | 2021 |
Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark.
Topics: Africa, Western; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Betu | 2021 |
Protocatechuic acid attenuates chronic unpredictable mild stress induced-behavioral and biochemical alterations in mice.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Biomarkers; Brain; Brain-Derived Neu | 2021 |
Protocatechuic Acid Suppresses Microglia Activation and Facilitates M1 to M2 Phenotype Switching in Intracerebral Hemorrhage Mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Cell Cycle Proteins; Cell L | 2021 |
Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Disease Models, Animal; HMGB1 Protein; Humans; Hydroxyb | 2021 |
Administration of Protocatechuic Acid Reduces Traumatic Brain Injury-Induced Neuronal Death.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Cell Count; Cell Death; Cerebral Cortex; Disease Mode | 2017 |
Antihypertensive and antioxidant effects of protocatechuic acid in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Desoxycorticosterone Acetate; Diseas | 2018 |
Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Mo | 2020 |
Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Depression; Disease | 2019 |
Protocatechuic acid exerts protective effects via suppression of the P38/JNK- NF-κB signalling pathway in an experimental mouse model of intracerebral haemorrhage.
Topics: Animals; Apoptosis; Brain Edema; Cell Line, Tumor; Cerebral Hemorrhage; Cytokines; Disease Models, A | 2019 |
Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment.
Topics: Animals; Brain; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Dopamine; Galact | 2019 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
Protocatechuic acid inhibits testicular and epididymal toxicity associated with methotrexate in rats.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Epididymis; Humans; Hydroxybenzoates; Lipid Pe | 2019 |
Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model.
Topics: Animals; Antioxidants; Biomarkers; Creatinine; Disease Models, Animal; Doxorubicin; Glutathione; Glu | 2019 |
Cannabinoid system involves in the analgesic effect of protocatechuic acid.
Topics: Acetic Acid; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyb | 2019 |
Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts.
Topics: Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Body Weight; Disease Models, Animal; | 2014 |
Cardioprotective effect of protocatechuic acid on myocardial ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Cardiotonic Agents; Caspase 3; Cells, Cultured; Disease Models, Animal; Hydroxyb | 2014 |
Protocatechuic acid, a novel active substance against avian influenza virus H9N2 infection.
Topics: Animals; Antiviral Agents; CD4-CD8 Ratio; Cytokines; Disease Models, Animal; Female; Hydroxybenzoate | 2014 |
Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Blotting, Western; Bronchoalveolar Lavage Flui | 2015 |
Protocatechuic acid protects brain mitochondrial function in streptozotocin-induced diabetic rats.
Topics: Animals; Anticarcinogenic Agents; Brain; Diabetes Mellitus, Experimental; Disease Models, Animal; Hy | 2015 |
Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cognition Disorders; Disease Models, Animal; | 2015 |
Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; | 2017 |
Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Antioxidants; Blood Glucose; Diabetes Complicatio | 2009 |
Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo.
Topics: Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Administration Schedu | 2010 |
Antioxidant, antimutagenic, and antidiabetic activities of edible leaves from Cnidoscolus chayamansa Mc. Vaugh.
Topics: Animals; Antimutagenic Agents; Antioxidants; Catechin; Chromatography, High Pressure Liquid; Diabete | 2010 |
Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Anthocyanins; Apolipoproteins E; Atherosclerosis; Cell Adhesion; Cell Line; Cells, Cultured | 2010 |
Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Hypolipidemic effect of avocado (Persea americana Mill) seed in a hypercholesterolemic mouse model.
Topics: Animals; Antioxidants; Dietary Fiber; Disease Models, Animal; Flour; Hydroxybenzoates; Hypercholeste | 2012 |
Novel antiplatelet activity of protocatechuic acid through the inhibition of high shear stress-induced platelet aggregation.
Topics: Adolescent; Adult; Animals; Blood Platelets; Cells, Cultured; Disease Models, Animal; Dose-Response | 2012 |
Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice.
Topics: Animals; Anticarcinogenic Agents; bcl-X Protein; Disease Models, Animal; Hydroxybenzoates; Lung Inju | 2012 |
Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anticarcinogenic Agents; Antioxidants; Aspartat | 2003 |
Protective effect of protocatechuic acid isopropyl ester against murine models of sepsis: inhibition of TNF-alpha and nitric oxide production and augmentation of IL-10.
Topics: Animals; Disease Models, Animal; Esters; Hydroxybenzoates; Interleukin-10; Male; Mice; Mice, Inbred | 2004 |
Hydroxyl radical production in the cortex and striatum in a rat model of focal cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Cerebral Cortex; Cerebrovascular Circulat | 2000 |