protocatechuic acid has been researched along with Colitis in 3 studies
protocatechuic acid: RN given refers to parent cpd; structure
3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS." | 7.85 | Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway. ( Almar, M; Crespo, I; González-Gallego, J; Mauriz, JL; Ortiz de Urbina, JJ; San-Miguel, B; Tuñón, MJ, 2017) |
| "Protocatechuic acid (PCA) is a natural component with multiple biological activities." | 5.91 | Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis. ( Hu, S; Li, L; Sun, X; Tan, Y; Xiao, S; Yang, X; Zhong, L; Zhou, F; Zhou, Z, 2023) |
| " Although protocatechuic acid (PCA) has a protective effect on colitis, the molecular mechanisms underlying its contribution to intestinal barrier function remain unknown." | 4.31 | Dietary protocatechuic acid redistributes tight junction proteins by targeting Rho-associated protein kinase to improve intestinal barrier function. ( Jang, SH; Jung, SK; Kim, MJ; Kim, S; Kim, SR; Lee, JJ; So, BR, 2023) |
| "(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS." | 3.85 | Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway. ( Almar, M; Crespo, I; González-Gallego, J; Mauriz, JL; Ortiz de Urbina, JJ; San-Miguel, B; Tuñón, MJ, 2017) |
| "Protocatechuic acid (PCA) is a natural component with multiple biological activities." | 1.91 | Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis. ( Hu, S; Li, L; Sun, X; Tan, Y; Xiao, S; Yang, X; Zhong, L; Zhou, F; Zhou, Z, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| So, BR | 1 |
| Kim, S | 1 |
| Jang, SH | 1 |
| Kim, MJ | 1 |
| Lee, JJ | 1 |
| Kim, SR | 1 |
| Jung, SK | 1 |
| Yang, X | 1 |
| Sun, X | 1 |
| Zhou, F | 1 |
| Xiao, S | 1 |
| Zhong, L | 1 |
| Hu, S | 1 |
| Zhou, Z | 1 |
| Li, L | 1 |
| Tan, Y | 1 |
| Crespo, I | 1 |
| San-Miguel, B | 1 |
| Mauriz, JL | 1 |
| Ortiz de Urbina, JJ | 1 |
| Almar, M | 1 |
| Tuñón, MJ | 1 |
| González-Gallego, J | 1 |
3 other studies available for protocatechuic acid and Colitis
| Article | Year |
|---|---|
Dietary protocatechuic acid redistributes tight junction proteins by targeting Rho-associated protein kinase to improve intestinal barrier function.
Topics: Animals; Caco-2 Cells; Claudin-2; Colitis; Dextran Sulfate; Humans; Inflammatory Bowel Diseases; Int | 2023 |
Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis.
Topics: Animals; Caco-2 Cells; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Dextrans; Disease Model | 2023 |
Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; | 2017 |