protocatechuic acid has been researched along with Brain Edema in 2 studies
protocatechuic acid: RN given refers to parent cpd; structure
3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Protocatechuic acid (PCA) has been proved possessing neuroprotection in ICH." | 5.56 | Protocatechuic acid attenuates brain edema and blood-brain barrier disruption after intracerebral hemorrhage in mice by promoting Nrf2/HO-1 pathway. ( Bian, L; Chen, X; Sun, Q; Sun, Y; Wang, B; Xi, Z; Xu, C; Zhong, Z, 2020) |
| "The brain edema following intracerebral hemorrhage (ICH) plays a key role in the recovery process." | 5.56 | Protocatechuic acid attenuates brain edema and blood-brain barrier disruption after intracerebral hemorrhage in mice by promoting Nrf2/HO-1 pathway. ( Bian, L; Chen, X; Sun, Q; Sun, Y; Wang, B; Xi, Z; Xu, C; Zhong, Z, 2020) |
| "Protocatechuic acid (PCA) has been proved possessing neuroprotection in ICH." | 1.56 | Protocatechuic acid attenuates brain edema and blood-brain barrier disruption after intracerebral hemorrhage in mice by promoting Nrf2/HO-1 pathway. ( Bian, L; Chen, X; Sun, Q; Sun, Y; Wang, B; Xi, Z; Xu, C; Zhong, Z, 2020) |
| "The brain edema following intracerebral hemorrhage (ICH) plays a key role in the recovery process." | 1.56 | Protocatechuic acid attenuates brain edema and blood-brain barrier disruption after intracerebral hemorrhage in mice by promoting Nrf2/HO-1 pathway. ( Bian, L; Chen, X; Sun, Q; Sun, Y; Wang, B; Xi, Z; Xu, C; Zhong, Z, 2020) |
| "Protocatechuic acid (PCA) has been well studied for its neuroprotection value in several diseases, but the effect in intracerebral haemorrhage (ICH) has not been reported." | 1.51 | Protocatechuic acid exerts protective effects via suppression of the P38/JNK- NF-κB signalling pathway in an experimental mouse model of intracerebral haemorrhage. ( Bian, L; Chen, X; Hu, X; Ren, J; Sun, Q; Sun, Y; Wang, B; Xi, Z; Yang, GY; Yang, Y; Zhong, Z, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xi, Z | 2 |
| Chen, X | 2 |
| Xu, C | 1 |
| Wang, B | 2 |
| Zhong, Z | 2 |
| Sun, Q | 2 |
| Sun, Y | 2 |
| Bian, L | 2 |
| Hu, X | 1 |
| Yang, Y | 1 |
| Ren, J | 1 |
| Yang, GY | 1 |
2 other studies available for protocatechuic acid and Brain Edema
| Article | Year |
|---|---|
Protocatechuic acid attenuates brain edema and blood-brain barrier disruption after intracerebral hemorrhage in mice by promoting Nrf2/HO-1 pathway.
Topics: Animals; Aquaporin 4; Blood-Brain Barrier; Brain; Brain Edema; Cerebral Hemorrhage; Gene Knockdown T | 2020 |
Protocatechuic acid exerts protective effects via suppression of the P38/JNK- NF-κB signalling pathway in an experimental mouse model of intracerebral haemorrhage.
Topics: Animals; Apoptosis; Brain Edema; Cell Line, Tumor; Cerebral Hemorrhage; Cytokines; Disease Models, A | 2019 |