protocatechuic acid has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
protocatechuic acid: RN given refers to parent cpd; structure
3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Protocatechuic acid (PCA) is a phenolic acid metabolite of the parent anthocyanin, kuromanin, found in blackberries and bilberries." | 1.56 | Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1 ( Baybayon-Grandgeorge, AN; Holsopple, J; Koza, LA; Linseman, DA; Mazzarino, RC; Olson, JR; Patterson, D; Pena, C; Winter, AN, 2020) |
| "Furthermore, PCA reduced astrogliosis and microgliosis in spinal cord, protected spinal motor neurons from apoptosis, and maintained neuromuscular junction integrity in transgenic mice." | 1.56 | Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1 ( Baybayon-Grandgeorge, AN; Holsopple, J; Koza, LA; Linseman, DA; Mazzarino, RC; Olson, JR; Patterson, D; Pena, C; Winter, AN, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Koza, LA | 1 |
| Winter, AN | 1 |
| Holsopple, J | 1 |
| Baybayon-Grandgeorge, AN | 1 |
| Pena, C | 1 |
| Olson, JR | 1 |
| Mazzarino, RC | 1 |
| Patterson, D | 1 |
| Linseman, DA | 1 |
| Bogdanov, MB | 1 |
| Ramos, LE | 1 |
| Xu, Z | 1 |
| Beal, MF | 1 |
1 review available for protocatechuic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
1 trial available for protocatechuic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
2 other studies available for protocatechuic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1
Topics: Amyotrophic Lateral Sclerosis; Animals; Anticarcinogenic Agents; Disease Models, Animal; Gliosis; Hy | 2020 |
Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Corpus Striatum; Humans; Hydroxybenzoates; Hydroxyl Radical; | 1998 |