prothionamide has been researched along with Heart-Diseases* in 1 studies
1 other study(ies) available for prothionamide and Heart-Diseases
Article | Year |
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[Use of the antioxidant ionol to prevent damage to the heart from prolonged administration of antitubercular preparations].
Prolonged administration of isoniazid, protionamide and rifampicin to white rats is accompanied by marked depression of myocardial contractile function determined by the distress of membranous mechanisms of calcium transport because of excessive activation of lipid peroxidation in cardiomyocyte biomembranes. Administration of ionol coupled with antituberculous drugs prevents their cardiotoxic effects. Topics: Animals; Antioxidants; Antitubercular Agents; Butylated Hydroxytoluene; Heart Diseases; Isoniazid; Male; Prothionamide; Rats; Rifampin; Time Factors | 1983 |