protectin-d1 and Sepsis

protectin-d1 has been researched along with Sepsis* in 2 studies

Reviews

1 review(s) available for protectin-d1 and Sepsis

ArticleYear
The role of pro-resolution lipid mediators in infectious disease.
    Immunology, 2014, Volume: 141, Issue:2

    Inflammation is an essential host defence against infection, but can be damaging when excessive. Resolution of inflammation is an active process, and the pro-resolution effects of lipoxins, resolvins and protectins have received significant interest. Here, we review emerging data on the role of these lipid mediators in infectious disease. Lipoxins influence host control of Mycobacterium tuberculosis, Toxoplasma gondii, Trypanosoma cruzi and Plasmodium berghei cerebral malaria in mice. Their effects are protective in toxoplasmosis, T. cruzi infection and cerebral malaria but detrimental in tuberculosis; related to the balance between pathogen-control and excessive immune response. Topical lipoxin abrogates the tissue damage seen in a rabbit model of Porphyromonas gingivalis periodontitis. The increased virulence of H5N1 influenza A virus in mice correlates with reduced expression of SOCS2, required to mediate the effects of lipoxin. Mice unable to synthesize lipoxin suffer increased lung pathology during respiratory syncytial virus infection. Protectin suppresses influenza A virus replication in vitro and increases survival in a mouse model of severe influenza infection. Resolvins were investigated in a number of animal models of systemic bacterial infection, and were found to enhance phagocytic clearance of bacteria, reduce inflammation severity, promote neutrophil apoptosis, modulate neutrophil chemotaxis and importantly, reduce mortality. Interestingly, resolvin also enhances the antibacterial effect of ciprofloxacin and vancomycin. Topical resolvin application reduces the severity of herpes simplex virus ocular infection in mice. If the effects of these mediators translate from pre-clinical studies into successful clinical trials, they represent promising new strategies in managing infectious disease.

    Topics: Acute Lung Injury; Animals; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Infections; Lipoxins; Sepsis

2014

Other Studies

1 other study(ies) available for protectin-d1 and Sepsis

ArticleYear
Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
    Nature communications, 2021, 03-17, Volume: 12, Issue:1

    GPR37 was discovered more than two decades ago, but its biological functions remain poorly understood. Here we report a protective role of GPR37 in multiple models of infection and sepsis. Mice lacking Gpr37 exhibited increased death and/or hypothermia following challenge by lipopolysaccharide (LPS), Listeria bacteria, and the mouse malaria parasite Plasmodium berghei. Sepsis induced by LPS and Listeria in wild-type mice is protected by artesunate (ARU) and neuroprotectin D1 (NPD1), but the protective actions of these agents are lost in Gpr37

    Topics: Adoptive Transfer; Animals; Artesunate; Disease Models, Animal; Docosahexaenoic Acids; Lipopolysaccharides; Listeria monocytogenes; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Pain; Phagocytosis; Plasmodium berghei; Receptors, G-Protein-Coupled; Sepsis

2021