protectin-d1 and Peripheral-Nerve-Injuries

protectin-d1 has been researched along with Peripheral-Nerve-Injuries* in 1 studies

Other Studies

1 other study(ies) available for protectin-d1 and Peripheral-Nerve-Injuries

ArticleYear
Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.
    Annals of neurology, 2013, Volume: 74, Issue:3

    Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1/PD1 treatment blocks nerve injury-induced long-term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain.

    Topics: Animals; Docosahexaenoic Acids; Mice; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Sciatic Nerve; Spinal Cord

2013