protectin-d1 and Chronic-Disease

The resolution of inflammation is a biosynthetically active process controlled by the interplay between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling pathways. These enzymatically oxygenated polyunsaturated fatty acids belong to distinct families of specialized pro-resolving autacoids. The protectin family of mediators has attracted an interest because of their potent pro-resolving and anti-inflammatory actions verified in several in vivo disease models. Herein, we present the stereoselective synthesis and biological evaluations of 3-oxa-PD1

Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Chronic Disease; Diabetic Neuropathies; Docosahexaenoic Acids; Female; Injections, Intraperitoneal; Male; Mice; Mice, Inbred NOD; Molecular Structure; Neoplasms, Experimental; Neuralgia; Pruritus; Streptozocin