prosultiamine and Chronic-Disease

In a 78-year-old woman with chronic respiratory tract infection caused by Pseudomonas aeruginosa with a mucoid phenotype, the organism was eliminated from the sputum by use of Kakkontou (Chinese herbal drug) and Alinamin F (Fursultiamine). Gram staining of a sputum smear showed mucoid micro-organisms were engulfed by neutrophils. Both drugs could change the mucoid character of this microorganism. It was suggested that polymorphonuclear leukocytes activated by Kakkontou could recognize this organism as a foreign body because of the changed mucoid character, and cleared it by phagocytosis.

Topics: Aged; Chronic Disease; Drugs, Chinese Herbal; Female; Humans; Pseudomonas Infections; Respiratory Tract Infections; Thiamine

A close correlation between purpuric reaction and drugs was observed in seven cases of chronic pigmented purpura. The patients developed purpuric lesions after taking certain drugs for more than 3 years, were thiamine propyldisulfide in 2 cases, and chlordiazepoxide in 1 case. The purpuric lesions stopped recurring after removal of the drugs in the rest of the cases. It is suggested that drugs are among the etiological factors in chronic pigmented purpura.

Topics: Aged; Chlordiazepoxide; Chronic Disease; Female; Furosemide; Humans; Male; Middle Aged; Nitroglycerin; Pigmentation Disorders; Purpura; Thiamine

The significance of intravenous olfaction test in olfactometry was studied by injection of thiamine propyldisulfide (Alinamin) intravenously. An original solution of Alinamin is a thiol-type derivative of vitamin B1, and releases a mercaptan smell (garlic smell) in expired air when it arrives at the olfactory epithelium via the nasopharynx. In the intravenous olfaction test (Alinamin test), the latent time which is a period between the initiation of injection and recognition of garlic smell, and duration time which is a period between the recognition and disappearance of smell are measured. Our results indicated that latent time is influenced by olfactory acuity and duration time depends on olfactory adaptation phenomenon. Central olfactory disorders were highly suspected in hyposmia patients with duration time of less than 15 sec, and nonresponders in Alinamin test always showed poor prognosis in the recovery of olfactory acuity. It was considered that the Alinamin test is useful not only for estimating the degree of olfactory disorders, but also for differential diagnosis of impaired lesions and olfactory prognosis.

Topics: Chronic Disease; Humans; Olfaction Disorders; Postoperative Complications; Prognosis; Reaction Time; Reference Values; Rhinitis; Sinusitis; Smell; Thiamine