prostaglandin-f2alpha-15-methyl-ether and Hemorrhage

Pregnancy was interrupted successfully in 70% of 20 early pregnancies, 35-49 days in duration as dated from the first day of the last menstrual period, by administration of a single intravaginal suppository containing 3 mg of (15S)-15-methyl prostaglandin F2 alpha (PGF2 alpha). No correlation could be demonstrated with baseline beta-subunit human chorionic gonadotropin or serum levels of prostaglandin obtained within ten hours of treatment. Continued pregnancy was documented in 10%. The rate of failures and the frequency of gastrointestinal side effects were deemed too great to warrant adopting this agent for clinical usage.

Topics: Abortion, Induced; Adult; Cross-Sectional Studies; Dinoprost; Female; Hemorrhage; Humans; Pregnancy; Pregnancy Trimester, First; Progesterone; Prostaglandins F, Synthetic; Sampling Studies; Suppositories; Time Factors; Vagina