prostaglandin-e2-ethanolamide and Glioma

prostaglandin-e2-ethanolamide has been researched along with Glioma* in 1 studies

Other Studies

1 other study(ies) available for prostaglandin-e2-ethanolamide and Glioma

ArticleYear
In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells.
    Bulletin of experimental biology and medicine, 2011, Volume: 151, Issue:1

    We studied the effects of endocannabinoid anandamide and its cyclooxygenase derivative prostamide E2 on cultured cerebellar granular cells and C6 glioma cells from rats. Prostamide E2 prevented apoptosis in cerebellar neurons induced by potassium deprivation of cultures, while anandamide had no neuroprotective properties. Prostamide E2 did not modulate the survival rate of glioma cells, while anandamide produced a cytotoxic effect. Our results indicate that cyclooxygenase transformation of anandamide is followed by the loss of antitumor activity of this agent. By contrast, prostamide E2 exhibited strong neuroprotective properties.

    Topics: Animals; Apoptosis; Arachidonic Acids; Biotransformation; Cell Survival; Cells, Cultured; Cerebellum; Dinoprostone; Dose-Response Relationship, Drug; Endocannabinoids; Glioma; Neurons; Neuroprotective Agents; Polyunsaturated Alkamides; Potassium; Potassium Deficiency; Primary Cell Culture; Prostaglandin-Endoperoxide Synthases; Rats

2011