prostaglandin-d2 has been researched along with Pulpitis* in 1 studies
1 other study(ies) available for prostaglandin-d2 and Pulpitis
Article | Year |
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Arachidonic-acid metabolism in normal and experimentally-inflamed rat dental pulp.
Pulp homogenates were incubated with [14C]-arachidonic acid and the metabolites separated by thin-layer chromatography. The main products of normal pulp were 6-keto-prostaglandin (PG) F1 alpha and 12-hydroxy-eicosatetraenoic acid (12-HETE), further identified by high performance-liquid chromatography. Thromboxane (TX) B2, and PGD2, E2 and F2 alpha were also detected at less than 30 per cent of 6-keto-PGF1 alpha. When the pulp was inflamed by applying bacterial lipopolysaccharide, production of all these metabolites increased; in particular, PGE2 was increased 9.3-fold compared with normal, and 6-keto-PGF1 alpha and HETE 3.8- and 2.0-fold, respectively. An unidentified product, slightly more polar than 12-HETE, was also markedly produced by the inflamed pulp. Thus arachidonic-acid metabolites including lipoxygenase products may be involved in the development of pulpal inflammation. Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Dental Pulp; Dinoprostone; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Male; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Pulpitis; Rats; Rats, Inbred Strains; Thromboxane B2 | 1987 |