prostaglandin-d2 has been researched along with Leishmaniasis* in 1 studies
1 other study(ies) available for prostaglandin-d2 and Leishmaniasis
| Article | Year |
|---|---|
Eosinophils increase macrophage ability to control intracellular Leishmania amazonensis infection via PGD
Clinical and experimental studies have described eosinophil infiltration in Leishmania amazonensis infection sites, positioning eosinophils strategically adjacent to the protozoan-infected macrophages in cutaneous leishmaniasis. Here, by co-culturing mouse eosinophils with L. amazonensis-infected macrophages, we studied the impact of eosinophils on macrophage ability to regulate intracellular L. amazonensis infection. Eosinophils prevented the increase in amastigote numbers within macrophages by a mechanism dependent on a paracrine activity mediated by eosinophil-derived prostaglandin (PG) D Topics: Animals; Eosinophils; Female; Leishmania; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Paracrine Communication; Prostaglandin D2; Receptors, Prostaglandin | 2021 |