prostaglandin-d2 and Angioedemas--Hereditary

I have spent my entire professional life at Harvard Medical School, beginning as a medical student. I have enjoyed each day of a diverse career in four medical subspecialties while following the same triad of preclinical areas of investigation-cysteinyl leukotrienes, mast cells, and complement-with occasional translational opportunities. I did not envision a career with a predominant preclinical component. Such a path simply evolved because I chose instinctively at multiple junctures to follow what proved to be propitious opportunities. My commentary notes some of the highlights for each area of interest and the mentors, collaborators, and trainees whose counsel has been immensely important at particular intervals or over an extended period.

Topics: Allergy and Immunology; Androstanols; Angioedemas, Hereditary; Bronchoconstriction; CD55 Antigens; Complement Activation; Complement Pathway, Alternative; Cromolyn Sodium; Hemoglobinuria, Paroxysmal; History, 20th Century; History, 21st Century; Mast Cells; Prostaglandin D2; Receptors, Leukotriene; SRS-A; Stem Cells; United States