proscillaridin and Coronary-Disease

proscillaridin has been researched along with Coronary-Disease* in 2 studies

Trials

1 trial(s) available for proscillaridin and Coronary-Disease

Article	Year
[Effect of proscillaridin-4'-methylether on pressure rise velocity in the left ventricle of patients with coronary heart disease (author's transl)]. Klinische Wochenschrift, 1977, Jul-15, Volume: 55, Issue:14 In a randomized, controlled, double-blind study 2 groups of 7 patients each with coronary heart disease received either 1 mg methylproscillaridin (MP) a cardiac glycoside of the squill intravenously, or placebo to test the inotropic effect of MP. Pressures and dp/dt max were measured in the left ventricle before and after coronary angiography after an average of 62 min (60 to 70 min). There was a significant (p less than 0.05) increase of dp/dt max in the MP-group (Wilcoxon-Mann-Whitney test). Left ventricular enddiastolic pressure was decreased from 16.1 to 13.6 mm Hg in the MP-group, and increased in theplacebo group from 12 to 13.7 mm Hg (mean values). Thus, a positive inotropic effect of the glycoside may be assumed. Topics: Angiography; Blood Pressure; Bufanolides; Clinical Trials as Topic; Coronary Angiography; Coronary Disease; Double-Blind Method; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Contraction; Placebos; Proscillaridin; Stimulation, Chemical; Time Factors	1977

Article

Year

[Effect of proscillaridin-4'-methylether on pressure rise velocity in the left ventricle of patients with coronary heart disease (author's transl)].

Klinische Wochenschrift, 1977, Jul-15, Volume: 55, Issue:14

In a randomized, controlled, double-blind study 2 groups of 7 patients each with coronary heart disease received either 1 mg methylproscillaridin (MP) a cardiac glycoside of the squill intravenously, or placebo to test the inotropic effect of MP. Pressures and dp/dt max were measured in the left ventricle before and after coronary angiography after an average of 62 min (60 to 70 min). There was a significant (p less than 0.05) increase of dp/dt max in the MP-group (Wilcoxon-Mann-Whitney test). Left ventricular enddiastolic pressure was decreased from 16.1 to 13.6 mm Hg in the MP-group, and increased in theplacebo group from 12 to 13.7 mm Hg (mean values). Thus, a positive inotropic effect of the glycoside may be assumed.

Topics: Angiography; Blood Pressure; Bufanolides; Clinical Trials as Topic; Coronary Angiography; Coronary Disease; Double-Blind Method; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Contraction; Placebos; Proscillaridin; Stimulation, Chemical; Time Factors

1977

Other Studies

1 other study(ies) available for proscillaridin and Coronary-Disease

Article	Year
[Trial of a combination of proscillaridin A, thioridazine and Cori ester in the ambulatory treatment of some cardiopathies, especially senile types]. Minerva medica, 1976, Sep-30, Volume: 67, Issue:46 The effect of an association of proscillaridin A, thioridazine and Cori ester in ambulatory management of certain heart diseases, particularly in aged subjects, was assessed. Satisfactory results were observed in 58.3% of cases, with significant improvement of cardiac erethism, psychomotor instability and sleep disturbances, as well as cardiac frequency and signs of myocardial insufficiency. It is felt that the association is of assistance in the treatment of certain heart diseases unaccompanied by frank signs of insufficiency, especially in aged subjects. Topics: Aged; Bufanolides; Coronary Disease; Drug Combinations; Female; Glucosephosphates; Heart Diseases; Heart Failure; Heart Valve Diseases; Humans; Hypertension; Male; Middle Aged; Proscillaridin; Pulmonary Heart Disease; Thioridazine	1976

Article

Year

[Trial of a combination of proscillaridin A, thioridazine and Cori ester in the ambulatory treatment of some cardiopathies, especially senile types].

Minerva medica, 1976, Sep-30, Volume: 67, Issue:46

The effect of an association of proscillaridin A, thioridazine and Cori ester in ambulatory management of certain heart diseases, particularly in aged subjects, was assessed. Satisfactory results were observed in 58.3% of cases, with significant improvement of cardiac erethism, psychomotor instability and sleep disturbances, as well as cardiac frequency and signs of myocardial insufficiency. It is felt that the association is of assistance in the treatment of certain heart diseases unaccompanied by frank signs of insufficiency, especially in aged subjects.

Topics: Aged; Bufanolides; Coronary Disease; Drug Combinations; Female; Glucosephosphates; Heart Diseases; Heart Failure; Heart Valve Diseases; Humans; Hypertension; Male; Middle Aged; Proscillaridin; Pulmonary Heart Disease; Thioridazine

1976