proscillaridin has been researched along with Alzheimer-Disease* in 2 studies
2 other study(ies) available for proscillaridin and Alzheimer-Disease
| Article | Year |
|---|---|
A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer's Amyloid-
Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer's disease (AD), and oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 is a mitochondrial protein regulating metabolic enzyme activity by deacetylation and its downregulation is associated with AD pathology. In the present study, we showed that a newly synthesized rhamnoside derivative PL171 inhibited the generation of reactive oxidant species (ROS) induced by amyloid- Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proton-Translocating ATPases; Neurons; Oxidative Stress; Oxygen; Peptide Fragments; Proscillaridin; Reactive Oxygen Species; Sirtuin 3; Superoxide Dismutase; Up-Regulation | 2020 |
PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling.
Neuroinflammation induced by overactivated glia cells is believed to be a major hallmark of Alzheimer's disease (AD) and a hopeful target against AD. A rhamnoside PL201 was previously reported to promote neurogenesis and ameliorate AD, and in this study, we revealed that PL201 also significantly reduced accumulation of the activated microglia and proinflammatory cytokines in APP/PS1 mice. Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line, Transformed; Cytokines; Female; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Microglia; NF-E2-Related Factor 2; Peptide Fragments; Presenilin-1; Proscillaridin; Signal Transduction; Treatment Outcome | 2020 |