proscillaridin and Achlorhydria

proscillaridin has been researched along with Achlorhydria* in 1 studies

Other Studies

1 other study(ies) available for proscillaridin and Achlorhydria

Article	Year
On the absorption of proscillaridin A after single oral doses to normal and achlorhydric subjects. Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1 Proscillaridin A was given in single oral doses (1.5-2.5 mg) to normal and achlorhydric subjects. Plasma activities of the glycoside were analysed by 86Rb-technique. The absorption pattern was similar in both groups. A marked first peak of proscillaridin activity was seen after about 30 min. After a first minimum, a second peak of activity was registered within 6-12 hrs. An estimate of the amount of active glycoside absorbed during the first 12 hrs after the administration was obtained by calculating the areas under the plasma activity curves (AUC). When corrected for differences in dose per kg body weight, the mean AUC in the achlorhydric group was about 60 per cent greater than in the normal group. The results suggest that proscillaridin is rapidly absorbed; gastric acidity seems to contribute to inter-individual differences in the bio-availability of the glycoside. Topics: Achlorhydria; Administration, Oral; Adult; Aged; Bufanolides; Female; Humans; Male; Middle Aged; Proscillaridin; Time Factors	1977

Article

Year

On the absorption of proscillaridin A after single oral doses to normal and achlorhydric subjects.

Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1

Proscillaridin A was given in single oral doses (1.5-2.5 mg) to normal and achlorhydric subjects. Plasma activities of the glycoside were analysed by 86Rb-technique. The absorption pattern was similar in both groups. A marked first peak of proscillaridin activity was seen after about 30 min. After a first minimum, a second peak of activity was registered within 6-12 hrs. An estimate of the amount of active glycoside absorbed during the first 12 hrs after the administration was obtained by calculating the areas under the plasma activity curves (AUC). When corrected for differences in dose per kg body weight, the mean AUC in the achlorhydric group was about 60 per cent greater than in the normal group. The results suggest that proscillaridin is rapidly absorbed; gastric acidity seems to contribute to inter-individual differences in the bio-availability of the glycoside.

Topics: Achlorhydria; Administration, Oral; Adult; Aged; Bufanolides; Female; Humans; Male; Middle Aged; Proscillaridin; Time Factors

1977