prosapogenin-a and Melanoma

prosapogenin-a has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for prosapogenin-a and Melanoma

Article	Year
Synthesis of novel spirostanic saponins and their cytotoxic activity. Bioorganic & medicinal chemistry, 2008, Feb-15, Volume: 16, Issue:4 This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds. Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Melanoma; Saponins; U937 Cells	2008

Article

Year

Synthesis of novel spirostanic saponins and their cytotoxic activity.

Bioorganic & medicinal chemistry, 2008, Feb-15, Volume: 16, Issue:4

This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.

Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Melanoma; Saponins; U937 Cells

2008