propylthiouracil and Ventricular-Dysfunction--Left

Hyperthyroidism is a common metabolic disorder, although its presentation as an endocrine emergency called thyroid storm is rare. Here we review a case of a thyroid storm as the initial presentation of thyrotoxicosis, with multiple organ failure and haemodynamic collapse due to low-output cardiac dysfunction. Quick intervention with aggressive antithyroid therapy, including steroid pulse, and supportive intensive care measures led to an outstanding improvement and full recovery. The present case clearly shows the beneficial impact of initial clinical suspicion resulting in an early diagnosis and intensive therapy. Moreover, it supports the additional role of steroids to aggressive antithyroid strategy in order to control associated deleterious systemic inflammatory reactions.

Topics: Anticholesteremic Agents; Antithyroid Agents; Cholestyramine Resin; Critical Care; Heart Rate; Hemodynamics; Humans; Iodides; Male; Middle Aged; Multiple Organ Failure; Propylthiouracil; Shock, Cardiogenic; Steroids; Thyroid Crisis; Treatment Outcome; Ventricular Dysfunction, Left; Weight Loss

Topics: Acute Disease; Adult; Antithyroid Agents; Female; Humans; Pancreatitis; Propylthiouracil; Ventricular Dysfunction, Left