propylthiouracil and Tachycardia
propylthiouracil has been researched along with Tachycardia* in 15 studies
Trials
1 trial(s) available for propylthiouracil and Tachycardia
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Clinical and endocrine features and long-term outcome of Graves' disease in early childhood.
Hyperthyroidism is rare in early childhood and most commonly caused by Graves' disease. We report 14 children (4 boys, 10 girls) aged 3.4-7.5 yr. At diagnosis, all patients had weight loss, hyperkinetic activity, tachycardia, difficulty sleeping, and poor concentration and 11 presented with proptosis. Four patients developed long-term neuropsychological problems. There was a family history in 7 cases. All patients had goiters, clinically assessed to be large and diffuse in 21%, medium-sized in 43%, and small in 36%. At diagnosis, height was increased with median (range) height; 1.25 standard deviation score (SDS) (-0.2-5.24) and body mass index (BMI) was decreased; -0.48 SDS (-1.65-1.26). Height and BMI SDS values were statistically different (p<0.032) Bone age was advanced in 4 of 5 children, who had assessments. Total or free T4 levels were elevated and TSH was undetectable. Ninety percent of patients (12/14) had positive thyroid peroxidase autoantibodies, mean level 680 IU/ml (range 50-1347). Initial treatment was with antithyroid medication using carbimazole; median dose 0.75 mg/kg/day (no.=13) or propylthiouracyl 15 mg/kg/day (no.=1). T4 was added in 6 patients. Normalisation of serum T4 occurred at 4 months (1- 9) and TSH at 7 months (3-24) after start of therapy. Treatment was discontinued after a minimum of 2 yr in 11 patients, relapse occurring in 9. Median duration of total therapy was 58 months (18-132). During adolescence, 4 patients had curative therapy by surgery (no.=2) or radioiodine (no.=2). In conclusion, disturbance of growth, behavioral difficulties and infrequent spontaneous remission are key features of Graves' disease in early childhood. Topics: Age of Onset; Antithyroid Agents; Attention Deficit Disorder with Hyperactivity; Carbimazole; Child; Child, Preschool; Exophthalmos; Female; Graves Disease; Growth Disorders; Humans; Hyperkinesis; Iodide Peroxidase; Male; Propylthiouracil; Recurrence; Retrospective Studies; Sleep Wake Disorders; Tachycardia; Thyrotropin; Thyroxine; Weight Loss | 2007 |
Other Studies
14 other study(ies) available for propylthiouracil and Tachycardia
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Simultaneous presentation of thyroid storm and diabetic ketoacidosis in a previously healthy 21-year-old man.
A 21-year-old young man with no history of diabetes or thyroid disease presented to the emergency department with simultaneous thyroid storm and diabetic ketoacidosis. Notable findings on admission were a ventricular rate of 235 beats/min, tachypnoea, tremors, polydipsia and a lack of fever. Due to the unusual constellation of symptoms, diagnosis was only possible after initial laboratory results came back. While the lack of fever is unusual in thyroid storm, diabetic ketoacidosis has previously been reported to suppress fever, and this case supports the occurrence of this phenomenon. This case was highly unusual because the patient had not previously been diagnosed with either type 1 diabetes or Graves' disease. Topics: Adult; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antithyroid Agents; Diabetic Ketoacidosis; Diagnosis, Differential; Humans; Hydrocortisone; Insulin; Male; Methimazole; Propranolol; Propylthiouracil; Tachycardia; Thyroid Crisis; Young Adult | 2019 |
The fetal heart monitor tracing in pregnancies complicated by fetal thyrotoxicosis.
Fetal tachycardia caused by the transplacental passage of thyroid stimulating immunoglobulin is well established, but very little information exists regarding the fetal heart rate appearance of this form of tachycardia. Two cases of fetal tachycardia are described in pregnancies complicated by fetal thyrotoxicosis where maternal thyroid history was unknown at the time of testing. For each pregnancy, the fetal heart monitor tracing is depicted and described. In both cases, the initial fetal heart rate pattern demonstrated a sustained baseline of 170 to 180 beats per minute with moderate variability that exhibited accelerations with a lack of decelerations. The tracings were essentially normal except for the baseline rate. When reviewing the differential for fetal tachycardia presenting in the antenatal period, this pattern is unique to fetal thyrotoxicosis, especially if the mother is afebrile and there is no history of medication usage that could explain this presentation. Topics: Adult; Antithyroid Agents; Cardiotocography; Female; Follow-Up Studies; Heart Rate, Fetal; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Propylthiouracil; Tachycardia; Thyrotoxicosis; Thyroxine; Treatment Outcome | 2009 |
[Case of thyroid crisis with persistent tachycardia diagnosed postoperatively].
A 35-year-old man with multiple bone fractures underwent an emergency operation. On arriving at the operating room, his heart rate was 160 beats x min(-1), and blood pressure was 100/50 mmHg. We anesthetized him with oxygen, sevoflurane, fentanyl and remifentanil. We suspected hypovolemia, and treated him with crystalloid and transfused red cells and fresh frozen plasma so that heart rate and blood pressure could be stabilized. Tachycardia of 140 beats x min(-1) persisted, and landiolol was continuously administered at a rate of 5-10 mg x hr(-1) after a 2.5 mg bolus injection. Heart rate became controlled around 120 beats x min(-1) without hypotension during anesthesia. Finally, we noticed thyroid crisis in this case, and diagnosed it with laboratory data after operation. We should be aware that atypical tachycardia is caused by thyroid crisis. Topics: Adult; Anti-Arrhythmia Agents; Emergencies; Fractures, Bone; Graves Disease; Humans; Intraoperative Complications; Iodine Compounds; Male; Morpholines; Orthopedic Procedures; Propylthiouracil; Tachycardia; Thyroid Crisis; Urea | 2009 |
Undiagnosed Graves' Disease contributing to sleep disordered breathing in a child undergoing adenotonsillectomy.
Topics: Acetaminophen; Adenoidectomy; Adenoids; Analgesics, Non-Narcotic; Analgesics, Opioid; Antihypertensive Agents; Antithyroid Agents; Atenolol; Child; Fentanyl; Follow-Up Studies; Graves Disease; Humans; Hydrocodone; Hypertension; Male; Palatine Tonsil; Propylthiouracil; Sleep Apnea Syndromes; Tachycardia; Thyroid Gland; Tonsillectomy | 2008 |
Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8.
Mutations of the monocarboxylate transporter 8 (MCT8) gene determine a distinct X-linked phenotype of severe psychomotor retardation and consistently elevated T(3) levels. Lack of MCT8 transport of T(3) in neurons could explain the neurological phenotype.. Our objective was to determine whether the high T(3) levels could also contribute to some critical features observed in these patients.. A 16-yr-old boy with severe psychomotor retardation and hypotonia was hospitalized for malnutrition (body weight = 25 kg) and delayed puberty. He had tachycardia (104 beats/min), high SHBG level (261 nmol/liter), and elevated serum free T(3) (FT(3)) level (11.3 pmol/liter), without FT(4) and TSH abnormalities. A missense mutation of the MCT8 gene was present. Oral overfeeding was unsuccessful. The therapeutic effect of propylthiouracil (PTU) and then PTU plus levothyroxine (LT(4)) was tested. After PTU (200 mg/d), serum FT(4) was undetectable, FT(3) was reduced (3.1 pmol/liter) with high TSH levels (50.1 mU/liter). Serum SHBG levels were reduced (72 nmol/liter). While PTU prescription was continued, high LT(4) doses (100 microg/d) were needed to normalize serum TSH levels (3.18 mU/liter). At that time, serum FT(4) was normal (16.4 pmol/liter), and FT(3) was slightly high (6.6 pmol/liter). Tachycardia was abated (84 beats/min), weight gain was 3 kg in 1 yr, and SHBG was 102 nmol/liter.. 1) When thyroid hormone production was reduced by PTU, high doses of LT(4) (3.7 microg/kg.d) were needed to normalize serum TSH, confirming that mutation of MCT8 is a cause of resistance to thyroid hormone. 2) High T(3) levels might exhibit some deleterious effects on adipose, hepatic, and cardiac levels. 3) PTU plus LT(4) could be an effective therapy to reduce general adverse features, unfortunately without benefit on the psychomotor retardation. Topics: Adolescent; Antithyroid Agents; Humans; Intellectual Disability; Male; Monocarboxylic Acid Transporters; Muscle Hypotonia; Mutation, Missense; Propylthiouracil; Puberty, Delayed; Symporters; Syndrome; Tachycardia; Thyroid Hormone Resistance Syndrome; Thyroid Hormones; Thyroxine; Treatment Outcome | 2008 |
Not just gastroenteritis: thyroid storm unmasked.
Establishing the diagnosis of thyroid storm is difficult in the ED, especially where there is no antecedent history of thyroid disease or clinical clues like goitre, exophthalmos or altered mentation, yet early recognition and treatment are essential in reducing mortality and morbidity from this endocrine emergency. We present a case where suspected infective gastroenteritis in a newly diagnosed diabetic masked the major symptomatology of thyroid storm, and review the diagnosis and management of thyrotoxic crisis. Topics: Anti-Arrhythmia Agents; Antithyroid Agents; Chills; Diabetes Complications; Diabetes Mellitus; Diagnosis, Differential; Diarrhea; Emergency Medicine; Female; Fever; Gastroenteritis; Humans; Insulin; Middle Aged; Propranolol; Propylthiouracil; Tachycardia; Thyroid Crisis | 2004 |
Gestational transient thyrotoxicosis.
Topics: Adult; Anti-Arrhythmia Agents; Antiemetics; Antithyroid Agents; Diagnosis, Differential; Emergency Medical Services; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Pregnancy Complications; Propranolol; Propylthiouracil; Tachycardia; Thyroid Hormones; Thyrotoxicosis; Treatment Outcome; Vomiting | 2003 |
Iatrogenic thyroid dysfunction.
Topics: Amiodarone; Humans; Hyperthyroidism; Male; Middle Aged; Propylthiouracil; Tachycardia; Thyroid Function Tests | 1989 |
Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.
Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective. This particular form of hyperthyroidism is long-lasting because of the slow elimination of amiodarone. Therefore, an alternative therapy is necessary, especially for patients who need to continue permanent administration of the drug. We report 2 cases of AIT: in one case, amiodarone was interrupted; in the other case, amiodarone was continued because of recurrent ventricular tachycardia resistant to classical antiarrhythmic drugs. Both patients were successfully treated with propylthiouracil (PTU) and dexamethasone (DXT). Topics: Amiodarone; Dexamethasone; Humans; Male; Middle Aged; Propylthiouracil; Tachycardia; Thyrotoxicosis | 1989 |
Thyroid storm--a nursing crisis.
A 48-year-old woman with a known history of hypothyroidism was admitted to the intensive care unit with a diagnosis of thyroid storm secondary to acute thyroid hormone poisoning and the possible hyperfunction of a singular thyroid nodule. Her clinical manifestations included pyrexia, tachycardia, tachypnea, hypertension, RUQ abdominal pain, psychotic behavior, and pharyngitis. She was successfully treated with sodium iodide, PTU, propranolol, antibiotics, and a hypothermia mattress, with her serum T4 level returning to normal range prior to discharge. The patient was discharged 9 days after admission in good medical health with no medication. This article clearly shows that the functions of the endocrine system remain a frontier in today's medicine. With research, perhaps one day we might fully understand the intricate pathophysiology that results in thyroid storm. The potential problem format has been utilized in the development of the nursing care plan to assist the nurse with identifying and defining her patient's problems, as well as directing her assessment and nursing intervention. As more is learned about thyroid storm, nurses should update their knowledge so that they will be prepared to care for the patient with these difficult nursing problems. Topics: Cold Temperature; Critical Care; Electrocardiography; Erythromycin; Female; Humans; Middle Aged; Monitoring, Physiologic; Patient Education as Topic; Propranolol; Propylthiouracil; Sodium Iodide; Tachycardia; Thyroid Crisis; Thyroid Gland; Thyroxine | 1983 |
Fetal thyrotoxicosis in utero.
A case of fetal thyrotoxicosis in utero in a boy with familial predisposition to thyrotoxicosis is reported. At 26 weeks of gestation fetal hyperkinesia and fetal tachycardia developed. This was preceded by a significant pathologic increase in long-acting thyroid stimulator (LATS) in the mother. The fetal hyperkinesia and tachycardia were considered to be signs of fetal thyrotoxicosis, possibly induced by placentally transferred LATS. The fetal thyrotoxicosis responded well to propylthiouracil given to the mother. After birth the boy developed slight signs of neonatal thyrotoxicosis although his serum thyroxine values increased analogous to those of his elder sister, who had presented classical neonatal thyrotoxicosis. Topics: Female; Fetal Diseases; Humans; Hyperkinesis; Hyperthyroidism; Infant, Newborn; Long-Acting Thyroid Stimulator; Male; Maternal-Fetal Exchange; Pregnancy; Propylthiouracil; Tachycardia; Thyroxine | 1979 |
[Neonatal hyperthyroidism].
Topics: Birth Weight; Body Weight; Digitalis Glycosides; Exophthalmos; Female; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Propylthiouracil; Tachycardia; Thyroid Function Tests | 1971 |
Thyrotoxicosis and heart disease in a nine-year-old girl. Remission with corticosteroids.
Topics: Age Factors; Cardiomegaly; Child; Electrocardiography; Female; Heart Auscultation; Heart Failure; Humans; Hyperthyroidism; Prednisone; Propylthiouracil; Recurrence; Remission, Spontaneous; Tachycardia | 1971 |
[ANGINA PECTORIS].
Topics: Amyl Nitrite; Angina Pectoris; Anticoagulants; Arteriovenous Fistula; Cholesterol; Erythrityl Tetranitrate; Hernia, Diaphragmatic; Humans; Hyperthyroidism; Hypotension; Magnesium; Nitroglycerin; Procainamide; Propylthiouracil; Stellate Ganglion; Stomach Ulcer; Sympathectomy; Syphilis; Syphilis, Cardiovascular; Tachycardia; Tachycardia, Paroxysmal | 1963 |