propylthiouracil and Sexual-Dysfunction--Physiological

propylthiouracil has been researched along with Sexual-Dysfunction--Physiological* in 1 studies

Other Studies

1 other study(ies) available for propylthiouracil and Sexual-Dysfunction--Physiological

ArticleYear
Chronic administration of imipramine normalizes decreased sexual motivation and increased predisposition to catalepsy induced by propylthiouracil in rats.
    Neuroscience and behavioral physiology, 2009, Volume: 39, Issue:4

    Thyroxine synthesis inhibitors increase the predisposition to catalepsy and decrease sexual motivation and the amplitude of the acoustic startle reflex in rats. The sensitivity of these behavioral changes to antidepressants remains uncertain. Chronic administration of the classical tricyclic antidepressant imipramine (15 mg/kg, 21 days) prevented the appearance of high sensitivity to catalepsy and the decrease in sexual motivation in Wistar rats given propylthiouracil (50 mg/liter, 28 days), without altering the amplitude of the startle reflex. Normalization of behavior in response to imipramine was not associated with changes in movement activity in the open field test or the animals' body weight. There was also no change in the expression of the 5-HT2A serotonin receptor gene in the frontal cortex. The model of propylthiouracilinduced catalepsy with reduced sexual motivation in rats has potential for studying the role of thyroid abnormalities in the development of depression and the mechanisms of action of antidepressants.

    Topics: Animals; Antidepressive Agents, Tricyclic; Antithyroid Agents; Catalepsy; Cerebral Cortex; Imipramine; Male; Propylthiouracil; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Sexual Behavior, Animal; Sexual Dysfunction, Physiological

2009