propylthiouracil and Schizophrenia

propylthiouracil has been researched along with Schizophrenia* in 1 studies

Other Studies

1 other study(ies) available for propylthiouracil and Schizophrenia

Article	Year
Inappropriate TSH secretion with abnormal thyrotroph sensitivity to dopamine. Clinical and investigative medicine. Medecine clinique et experimentale, 1985, Volume: 8, Issue:2 A 47-year-old male schizophrenic with hyperthyroidism was found to have non-neoplastic inappropriate thyrotropin (TSH) secretion. Anterior pituitary function, CT scan and alpha subunit determinations were normal. TSH rose after TRH (7.8 to 22.5 microU/ml) and propylthiouracil (26.1 microU/ml after 3 months) and decreased with oral T3 (Cytomel 25 micrograms po q.i.d.). Cytomel and glucocorticoid infusion blunted but did not completely suppress the TSH response to TRH. Intravenous dopamine infusion (4 micrograms/kg/min) completely suppressed the prolactin but not the TSH response to TRH. The association of schizophrenia and differential thyrotroph sensitivity to dopamine suggests a possible role for dopamine in the pathogenesis of selected cases of non-neoplastic inappropriate TSH secretion. Topics: Dopamine; Humans; Hydrocortisone; Infusions, Parenteral; Male; Middle Aged; Pituitary Gland, Anterior; Prolactin; Propylthiouracil; Schizophrenia; Thyroid Hormones; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine	1985

Article

Year

Inappropriate TSH secretion with abnormal thyrotroph sensitivity to dopamine.

Clinical and investigative medicine. Medecine clinique et experimentale, 1985, Volume: 8, Issue:2

A 47-year-old male schizophrenic with hyperthyroidism was found to have non-neoplastic inappropriate thyrotropin (TSH) secretion. Anterior pituitary function, CT scan and alpha subunit determinations were normal. TSH rose after TRH (7.8 to 22.5 microU/ml) and propylthiouracil (26.1 microU/ml after 3 months) and decreased with oral T3 (Cytomel 25 micrograms po q.i.d.). Cytomel and glucocorticoid infusion blunted but did not completely suppress the TSH response to TRH. Intravenous dopamine infusion (4 micrograms/kg/min) completely suppressed the prolactin but not the TSH response to TRH. The association of schizophrenia and differential thyrotroph sensitivity to dopamine suggests a possible role for dopamine in the pathogenesis of selected cases of non-neoplastic inappropriate TSH secretion.

Topics: Dopamine; Humans; Hydrocortisone; Infusions, Parenteral; Male; Middle Aged; Pituitary Gland, Anterior; Prolactin; Propylthiouracil; Schizophrenia; Thyroid Hormones; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine

1985