propylthiouracil and Nephritis--Interstitial

Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin A nephropathy and Graves' disease, which was successfully treated with corticosteroids. To the best of our knowledge, this is the first time such a case has been documented since tubulointerstitial nephritis and uveitis syndrome was first described.. A 64-year-old Japanese woman presented with tubulointerstitial nephritis and uveitis syndrome accompanied by immunoglobulin A nephropathy and Graves' disease. She had renal dysfunction, proteinuria, and hematuria. Two weeks after her admission, she developed anterior chamber uveitis. She received corticosteroids, resulting in significant clinical improvement.. Tubulointerstitial nephritis and uveitis syndrome is a relatively uncommon cause of tubulointerstitial nephritis. Clinicians should recognize that tubulointerstitial nephritis and uveitis syndrome with immunoglobulin A nephropathy can occur in the presence of Graves' disease. Additionally, this report may provide important clues in terms of the management of a concomitant case of these diseases.

Topics: Antithyroid Agents; Biopsy; Female; Glomerulonephritis, IGA; Glucocorticoids; Graves Disease; Humans; Kidney; Methylprednisolone; Middle Aged; Nephritis, Interstitial; Prednisolone; Propylthiouracil; Syndrome; Treatment Outcome; Uveitis

We report a case of acute interstitial nephritis and fatal Stevens-Johnson syndrome in a 90-year-old woman with amiodarone-induced hyperthyroidism, who had been treated for 5 weeks with propylthiouracil (PTU). On admission, the patient exhibited acute renal failure and generalized macular purpuric eruption. Acute interstitial nephritis and Stevens-Johnson syndrome were diagnosed and PTU withdrawn. Although renal function recovered after PTU withdrawal and corticosteroid therapy, the patient's condition worsened, and she died after developing multiple organ failure. Acute interstitial nephritis seems to be rarely associated with PTU therapy. Moreover, a literature review suggested that this could represent the first published report of a Stevens-Johnson syndrome developing during PTU therapy.

Topics: Acute Disease; Aged; Aged, 80 and over; Antithyroid Agents; Female; Humans; Nephritis, Interstitial; Propylthiouracil; Stevens-Johnson Syndrome

Topics: Adult; Antithyroid Agents; Diagnosis, Differential; Female; Humans; Hyperthyroidism; Kidney Failure, Chronic; Nephritis, Interstitial; Propylthiouracil; Sjogren's Syndrome; Time Factors

Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Antithyroid Agents; Female; Humans; Hyperthyroidism; Kidney Function Tests; Male; Nephritis, Interstitial; Prednisolone; Propylthiouracil; Renal Dialysis

Propylthiouracil therapy is associated with a variety of adverse reactions. Renal involvement, although rare, has occurred, but neither acute interstitial nephritis nor severe acute renal failure has been reported previously. We report a case of fulminant acute interstitial nephritis with renal failure following treatment with propylthiouracil.

Topics: Acute Disease; Acute Kidney Injury; Adult; Humans; Male; Nephritis, Interstitial; Propylthiouracil