propylthiouracil and Muscular-Diseases

Neuromuscular disorders associated with hyperthyroidism have several variations in their clinical phenotype, such as ophthalmopathy, periodic paralysis, and thyrotoxic myopathy. We herein report an unusual case of thyrotoxic myopathy presenting as unilateral drop foot. Histopathological examinations of the left tibialis anterior muscle showed marked variation in the fiber size, mild inflammatory cell infiltration, and necrotic and regenerated muscle fibers with predominantly type 1 fiber atrophy. Medical treatment with propylthiouracil resulted in complete improvement of the left drop foot. This case expands the phenotype of thyrotoxicosis and suggests that thyrotoxicosis be considered as a possible cause of unilateral drop foot.

Topics: Adolescent; Antithyroid Agents; Biopsy; Female; Gait Disorders, Neurologic; Humans; Magnetic Resonance Imaging; Muscle, Skeletal; Muscular Diseases; Necrosis; Paralysis; Propylthiouracil; Thyrotoxicosis

Topics: Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Hyperthyroidism; Joint Diseases; Male; Movement Disorders; Muscular Diseases; Propylthiouracil; Thyroidectomy

Topics: Adult; Female; Humans; Hyperthyroidism; Muscular Diseases; Porphyrias; Propylthiouracil