propylthiouracil has been researched along with Lupus-Nephritis* in 4 studies
1 review(s) available for propylthiouracil and Lupus-Nephritis
| Article | Year |
|---|---|
Propylthiouracil-induced diffuse proliferative lupus nephritis: review of immunological complications.
Propylthiouracil (PTU), used to treat Graves' disease, occasionally induces a lupus-like syndrome. A 39-year-old woman developed clinical manifestations of systemic lupus erythematosus with rash, serositis, myocarditis, and acute renal insufficiency, associated with serologies for lupus, after 3 wk of exposure to the drug. Renal biopsy revealed diffuse proliferative lupus nephritis. This article reviews the side effects of PTU and the literature on PTU-induced nephrotoxicity. Possible mechanisms and management of drug-induced lupus nephritis are also reviewed. To facilitate early and specific intervention, clinicians should be aware of the propensity of PTU to cause lupus-like syndromes with renal involvement. Topics: Adult; Antigen-Antibody Complex; Antithyroid Agents; Female; Fluorescent Antibody Technique, Direct; Graves Disease; Humans; Kidney; Lupus Nephritis; Propylthiouracil | 1997 |
3 other study(ies) available for propylthiouracil and Lupus-Nephritis
| Article | Year |
|---|---|
Lupus nephritis with positive myeloperoxidase/proteinase 3-antineutrophil cytoplasmic autoantibody that developed after 17 years of propylthiouracil therapy.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antithyroid Agents; Graves Disease; Humans; Lupus Nephritis; Male; Middle Aged; Peroxidase; Propylthiouracil | 2014 |
Propylthiouracil-induced lupus-like syndrome: successful management with oral corticosteroids.
Topics: Female; Goiter, Nodular; Humans; Lupus Nephritis; Middle Aged; Prednisone; Propylthiouracil | 2005 |
Class IV lupus nephritis associated with Graves' disease.
Graves' disease was initially diagnosed in an 11-year-old Chinese boy in March 1989. After regular propylthiouracil (PTU) and thyroxine, he achieved a euthyroid state. Heavy proteinuria with class IV lupus glomerulonephritis, anemia, arthralgia, low serum complement and anti-dsDNA (+) appeared 15 months later. Thyrotoxicosis also relapsed at this time. His condition fitted the diagnostic criteria of systemic lupus erythematosus. His antimicrosomal antibody titer was 1:1,600 (+) thyroid-stimulating hormone receptor antibody level was strongly positive, and the titer of antiinsulin antibody was high as well. These clinical, laboratory and histological findings indicate that class IV lupus nephritis may be associated with Graves' disease. Topics: Carbimazole; Child; Chlorambucil; Graves Disease; Humans; Lupus Nephritis; Male; Prednisolone; Propylthiouracil; Thyroxine | 1992 |