propylthiouracil and Febrile-Neutropenia

The authors present the case history of a patient suffering from hyperthyroidism. The diagnostic procedures revealed the presence of propylthiouracyl induced vasculitis with renal involvement, that recovered completely after the withdrawal of propylthiouracyl and corticosteroid treatment. Thereafter, the patient was treated with thiamasol, that caused agranulocytosis with fever. After transient litium carbonate therapy a succesful thyreoidectomy was performed. Cumulative serious side effects of antithyroid drugs are rare. This case highlights some of the challenges and complications encountered in the management of hyperthyroidism.

Topics: Adult; Antithyroid Agents; Febrile Neutropenia; Female; Humans; Hyperthyroidism; Methimazole; Propylthiouracil; Thyroidectomy; Vasculitis