propylthiouracil and Brain-Injuries

In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

Topics: Animals; Antioxidants; Antithyroid Agents; Avoidance Learning; Benzoquinones; Brain Injuries; Catalase; Disease Models, Animal; Hippocampus; Hypothyroidism; Learning Disabilities; Male; Malondialdehyde; Maze Learning; Memory Disorders; Nitric Oxide; Oxidative Stress; Propylthiouracil; Rats, Wistar; Superoxide Dismutase

Topics: Animals; Body Weight; Brain Injuries; Cartilage; Cortisone; Disease Models, Animal; Fasting; Growth; Growth Disorders; Growth Hormone; Humans; Intellectual Disability; Pituitary Gland; Propylthiouracil; Radiation Injuries, Experimental; Rats; Somatomedins; Sulfates