propylene glycol and Eye Pain studies

Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.

Eye Pain: A dull or sharp painful sensation associated with the outer or inner structures of the eyeball, having different causes.

Research Excerpts

Excerpt	Relevance	Reference
"Xanthan gum/chondroitin sulfate preservative free showed similar clinical efficacy, evaluated with OSDI score, TBUT and Schirmer test compared to polyethylene glycol/propylene glycol in the treatment of dry eye disease."	9.22	Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial. ( Belalcazar-Rey, S; Ochoa-Tabares, JC; Oregón-Miranda, AA; Pérez-Balbuena, AL; Rodríguez-Carrizalez, AD; Saucedo-Rodríguez, LR; Suárez-Sánchez, RG; Urzúa-Salinas, C; Velasco-Ramos, R, 2016)
"Xanthan gum/chondroitin sulfate preservative free showed similar clinical efficacy, evaluated with OSDI score, TBUT and Schirmer test compared to polyethylene glycol/propylene glycol in the treatment of dry eye disease."	5.22	Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial. ( Belalcazar-Rey, S; Ochoa-Tabares, JC; Oregón-Miranda, AA; Pérez-Balbuena, AL; Rodríguez-Carrizalez, AD; Saucedo-Rodríguez, LR; Suárez-Sánchez, RG; Urzúa-Salinas, C; Velasco-Ramos, R, 2016)
" Although the ointment presented antinociceptive effect, it is concluded that BISA when associated with propylene glycol has better potential for corneal nociceptive pain since it is more comfortable to use, leading to greater acceptance by patients."	3.85	Corneal antinociceptive effect of (-)-α-bisabolol. ( Campos, AR; Costa, FN; Teixeira, GF, 2017)

Research

Studies (2)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Pérez-Balbuena, AL	1
Ochoa-Tabares, JC	1
Belalcazar-Rey, S	1
Urzúa-Salinas, C	1
Saucedo-Rodríguez, LR	1
Velasco-Ramos, R	1
Suárez-Sánchez, RG	1
Rodríguez-Carrizalez, AD	1
Oregón-Miranda, AA	1
Teixeira, GF	1
Costa, FN	1
Campos, AR	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of PRO-148 Versus Systane®, in Patients With Mild to Moderate Dry Eye[NCT01657253]	Phase 3	183 participants (Actual)	Interventional	2013-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Ocular Surface Disease Index (OSDI©) questionnaire , consists of 12 questions divided in 3 groups, Each question has a value that can go from 0 to 4 points according to the severity of the case: 0.None of the time, 1. Some of the time, 2.Half of the time, 3.most of the time and 4 all of the time. The points of all the questions will be used in the following formula for converted to a score of 0-100 : (sum of scores) x 25 / (# of questions answered), where 0 represents normality or non-symptomatology and 100 the most severe case. Will be used to measure the symptoms of dry eye disease by obtaining baseline data and comparing them against the last visit. (NCT01657253)
Timeframe: Day 60

Schirmer Test

Intervention	points (Mean)
	baseline values	final values
PRO-148	19.3	7.3
Systane®	19.3	7.9

"Change from Baseline in Schirmer test after 60 days of treatment~Schirmer test~It is the technique most used to measure aqueous and at the same time the simplest tear secretion. It is carried out as follows: Without applying anesthesia, the patient is placed somewhere without much illumination, without applying anesthesia, a strip of filter paper of approximately 30 mm is placed, of which, 5 mm must go in the joint Of the middle and outer third of the lower eyelid. The patient is instructed to look forward and to blink normally. After 5 minutes the strips are removed and the wetting is recorded in millimeters. A test less than or equal to 6 mm is diagnostic of aqueous deficiency.The mean of the revisions by group will be compared at the baseline and final visit." (NCT01657253)
Timeframe: Day 60

Tear Film Break up Time

Intervention	mm/min (Mean)
	baseline values	final values
PRO-148	6.4	11.0
Systane®	6.5	10.5

Change from Baseline in Tear film break up time after 60 days of treatment Tear film breakup time is the elapsed time from blinking to the first occurrence of a dry area in the cornea, visualized with the help of fluorescein staining. Measurement of tear film breakup time will be performed as follows: Fluorescein is instilled in the eye, the patient is asked to blink three times to distribute the dye and then set the eye to the front and do not blink while the examiner observes the cornea with cobalt blue light, looking for an area of tear film rupture, which is manifested by the appearance of a black island within the fluorescein green film. Normally film breakup time is 10 seconds or more and the minimum register may be 1 second, Under 10 seconds is considered abnormal. (NCT01657253)
Timeframe: Day 60

propylene glycol and Eye Pain