propylene glycol has been researched along with Critical Illness in 6 studies
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Serum propylene glycol concentrations were drawn at 48 hrs into the high-dose lorazepam infusion, and the presence of propylene glycol accumulation, as evidenced by a high anion gap (> or =15 mmol/L) metabolic acidosis with elevated osmol gap (> or =10 mOsm/L), was assessed at that time." | 5.11 | Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults. ( Arroliga, AC; Gonzales, JP; McCarthy, K; Shehab, N, 2004) |
| "Benzyl alcohol exposure was likely to be several-fold high in critically ill patients." | 1.56 | Possible effects of excipients used in the parenteral drugs administered in critically ill adults, children, and neonates. ( Al Ansari, E; Al Daylami, A; Al Jufairi, M; Hasan, HM; Pasha, SAA; Qader, AM; Sridharan, K, 2020) |
| "Propylene glycol accumulation was defined as concentrations of 25 mg/dL or more." | 1.35 | Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions. ( Fish, DN; Horinek, EL; Kiser, TH; MacLaren, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sridharan, K | 1 |
| Hasan, HM | 1 |
| Al Jufairi, M | 1 |
| Al Daylami, A | 1 |
| Al Ansari, E | 1 |
| Qader, AM | 1 |
| Pasha, SAA | 1 |
| Shehab, N | 2 |
| Lewis, CL | 1 |
| Streetman, DD | 1 |
| Donn, SM | 1 |
| Horinek, EL | 1 |
| Kiser, TH | 1 |
| Fish, DN | 1 |
| MacLaren, R | 1 |
| Arroliga, AC | 1 |
| McCarthy, K | 1 |
| Gonzales, JP | 1 |
| Jacobi, J | 1 |
| Bouchard, NC | 1 |
| Fulton, JA | 1 |
| Hoffman, RS | 1 |
1 trial available for propylene glycol and Critical Illness
| Article | Year |
|---|---|
Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Critical Illness; Dose-Response Relationship, Drug; Female; | 2004 |
5 other studies available for propylene glycol and Critical Illness
| Article | Year |
|---|---|
Possible effects of excipients used in the parenteral drugs administered in critically ill adults, children, and neonates.
Topics: Adult; Benzyl Alcohol; Child; Child, Preschool; Critical Illness; Excipients; Female; Humans; Infant | 2020 |
Exposure to the pharmaceutical excipients benzyl alcohol and propylene glycol among critically ill neonates.
Topics: Benzyl Alcohol; Critical Illness; Dose-Response Relationship, Drug; Excipients; Humans; Infant, Newb | 2009 |
Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions.
Topics: Adult; Age Factors; Aged; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Hypnot | 2009 |
Medication vehicle injury--using the proper restraint?
Topics: Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Huma | 2004 |
Propylene glycol accumulation after high-dose lorazepam: what have we learned?
Topics: Acid-Base Equilibrium; Acidosis; Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intra | 2005 |