propylene glycol has been researched along with Brain Edema in 2 studies
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "For the treatment of postoperative seizures and prevention of brain edema, an etomidate drip was used in conjunction with phenytoin, diazepam, pentobarbital, and phenobarbital in a 70-year-old woman." | 3.68 | A case of propylene glycol toxic reaction associated with etomidate infusion. ( Bedichek, E; Kirschbaum, B, 1991) |
| " We believed that this represented an adverse effect that was probably related to the study drug and the study was stopped." | 2.68 | Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema. ( Aranda, M; Giannotta, SL; Levy, ML; Zelman, V, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levy, ML | 1 |
| Aranda, M | 1 |
| Zelman, V | 1 |
| Giannotta, SL | 1 |
| Bedichek, E | 1 |
| Kirschbaum, B | 1 |
1 trial available for propylene glycol and Brain Edema
| Article | Year |
|---|---|
Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anesthetics, Intravenous; Brain; Brain Edema; Drug Adm | 1995 |
1 other study available for propylene glycol and Brain Edema
| Article | Year |
|---|---|
A case of propylene glycol toxic reaction associated with etomidate infusion.
Topics: Acidosis, Lactic; Aged; Anticonvulsants; Brain Edema; Drug Therapy, Combination; Epilepsy, Tonic-Clo | 1991 |